2.3.1.46: homoserine O-succinyltransferase

This is an abbreviated version!
For detailed information about homoserine O-succinyltransferase, go to the full flat file.

Reaction

Synonyms

homoserine O-succinyltransferase, homoserine O-transsuccinylase, homoserine succinyltransferase, homoserine transsuccinylase, homoserine-O-succinyltransferase, HST, HTS, MetA, MetA protein, succinyltransferase, homoserine

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.46 homoserine O-succinyltransferase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
8536	AA Sequence
2	Application
1	CAS Registry Number
12	Cloned(Commentary)
2	Cofactor
1	Crystallization (Commentary)
7	General Information
2	General Stability
14	Inhibitors
6	kcat/KM [mM/s]
4	Ki Value [mM]
56	KM Value [mM]
3	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
45	Organism
7	Pathway
7	PDB ID
5	pH Optimum
6	pH Range
70	Protein Variants
6	Purification (Commentary)
5	Reaction
1	Reaction Type
18	Reference
2	Source Tissue
7	Specific Activity [micromol/min/mg]
28	Substrates and Products (Substrate)
2	Subunits
24	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
2	Temperature Range [°C]
3	Temperature Stability [°C]
40	Turnover Number [1/s]

pH Range

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

pH Range on EC 2.3.1.46 - homoserine O-succinyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to pH Range Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

5.4 - 7.5

2 entries

6 - 8.7

Escherichia coli

-

-

487046

6.2 - 8.5

Escherichia coli

-

pH profile of mutant K47R

672232

6.9 - 8

Escherichia coli

-

crude extract, about 40% of maximal activity at pH 6.9, about 80% of maximal activity at pH 8.0

487043

additional information

Escherichia coli

-

pKs of 6.6 and about 7.9

487046

5.4 - 7.5

Escherichia coli

-

25°C, histidine-tagged enzymes, 0-50 mM acetic acid: 0 mM = pH 7.5, 10 mM = 7.0, 20 mM = 6.6, 30 mM = 6.2, 40 mM = 5.8, 50 mM = 5.4, sharp decrease of wild-type enzyme activity above 30 mM acetic acid, no activity at 50 mM, without acid about 2900 micromol/min/mg protein, the mutant strain 333 (S61T/E213V/I229T/N267D/N271K) enzyme retains almost 50% activity at 50 mM acetic acid, activity decreases above 30 mM from about 2000 micromol/min/mg protein, the mutants N267D and I229T do not greatly change their activity, about 2000-1800 micromol/min/mg protein, and about 2500-2000 micromol/min/mg protein, respectively

701784

5.4 - 7.5

Geobacillus kaustophilus

-

25°C, histidine-tagged enzyme, 0-50 mM acetic acid: 0 mM = pH 7.5, 10 mM = 7.0, 20 mM = 6.6, 30 mM = 6.2, 40 mM = 5.8, 50 mM = 5.4, the recombinant enzyme shows reduced activity at 25°C without great change at about 200 micromol/min/mg protein, about 3.5times higher activity at 40°C

701784