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2.3.1.97: glycylpeptide N-tetradecanoyltransferase

This is an abbreviated version!
For detailed information about glycylpeptide N-tetradecanoyltransferase, go to the full flat file.

Word Map on EC 2.3.1.97

Reaction

tetradecanoyl-CoA
+
an N-terminal-glycyl-[protein]
=
CoA
 +
an N-terminal-N-tetradecanoylglycyl-[protein]

Synonyms

CaNMT, cell division control protein 72, dipeptide N-myristoyltransferase 2, glycylpeptide N-tetradecanoyltransferase, glycylpeptide N-tetradecanoyltransferase 1, glycylpeptide N-tetradecanoyltransferase 2, HsNMT1, HsNMT2, LmNMT, More, myristoyl-CoA-protein N-myristoyltransferase, myristoyl-CoA: protein N-myristoyltransferase, myristoyl-CoA:protein N-myristoyltransferase, myristoyl-CoA:protein N-myristoyltransferase 1, myristoyl-CoA:protein N-myristoyltransferase 2, myristoyl-CoA:protein N-myristoyltransferase type 2, myristoyl-coenzyme A:protein N-myristoyl transferase, myristoyl-coenzyme A:protein N-myristoyltransferase, myristoylating enzymes, myristoyltransferase, myristoyltransferase type 1, myristoyltransferase, protein N-, N-myristoyl transferase, N-myristoyltransferase, N-myristoyltransferase 1, N-myristoyltransferase 2, NMT, NMT 1, NMT 2, NMT-1, NMT-2, NMT1, Nmt1p, NMT2, peptide N-myristoyltransferase, peptide N-myristoyltransferase 1, peptide N-myristoyltransferase 2, protein N-myristoyltransferase, PVX_085815, TbNMT, type I N-myristoyltransferase, type II N-myristoyltransferase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.97 glycylpeptide N-tetradecanoyltransferase

IC50 Value

IC50 Value on EC 2.3.1.97 - glycylpeptide N-tetradecanoyltransferase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00000049
(1R,3S)-N-[2-[(cyclopentylcarbonyl)amino]-1,3-benzothiazol-6-yl]-3-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide
Candida albicans
IC50: 0.00000049 mM
0.000015
(1R,3S)-N-[2-[(cyclopentylcarbonyl)amino]-1,3-benzothiazol-6-yl]-3-[(naphthalen-2-ylmethyl)amino]cyclopentanecarboxamide
Candida albicans
IC50: 0.000015 mM
0.00000049
(1R,3S)-N-{2-[(cyclopeanthylcarbonyl)amino]-benzothiazol-6-yl}-3-[(2-naphthylmethyl) amino] cyclohexanecarboxamide
Candida albicans
competitive with the substrate peptide and non-competitive with myristoyl-CoA. IC50: 0.49 nM
0.00001
(1S,3R)-N-[2-[(cyclopentylcarbonyl)amino]-1,3-benzothiazol-6-yl]-3-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide
Candida albicans
IC50: above 0.00001 mM
0.000011
(1S,3R)-N-[2-[(cyclopentylcarbonyl)amino]-1,3-benzothiazol-6-yl]-3-[(naphthalen-2-ylmethyl)amino]cyclopentanecarboxamide
Candida albicans
IC50: 0.000011mM
100
1,12-dodecanedicarboxylic acid
Homo sapiens
IC50 above 100 mM
100
1,3-dimyristoylglycerol
Homo sapiens
IC50 above 100 mM
0.0001
1-(4-(3,5-dichloro-4-((2-methylpyridin-3-yl)methoxy)phenyl)pyridin-2-yl)piperazine
Trypanosoma brucei
-
pH 7.4, 22°C
0.00008
1-(4-(3,5-dichloro-4-((2-phenylpyridin-3-yl)methoxy)phenyl)-pyridin-2-yl)piperazine
Trypanosoma brucei
-
pH 7.4, 22°C
0.00002 - 0.0001
1-(4-(3,5-dichloro-4-(pyridin-2-ylmethoxy)phenyl)pyridin-2-yl)-piperazine
0.000001
1-(5-[3,4-difluoro-2-[2-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethoxy]phenyl]-1-methyl-1H-indazol-3-yl)-N,N-dimethylmethanamine
Homo sapiens
IC50 value below 1 nM, pH not specified in the publication, temperature not specified in the publication
0.0086
1-acetyl-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-2,3-dihydro-1H-indole-5-sulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
1 - 100
1-myristoyl-rac-glycerol
Homo sapiens
IC50 in the range 1-100 mM
1 - 100
1-Tetradecanal
Homo sapiens
IC50 in the range 1-100 mM
100
1-Tetradecanol
Homo sapiens
IC50 above 100 mM
0.0043
2,6-dichloro-4-(1,2,3,4-tetrahydroisoquinolin-5-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.000002
2,6-dichloro-4-(2-piperazin-1-ylpyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.049
2,6-dichloro-4-(isoquinolin-5-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.000012
2,6-dichloro-4-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-N-(1,5-dimethyl-3-isobutyl-1H-pyrazol-4-yl)benzenesulfonamide
Aspergillus fumigatus
pH not specified in the publication, temperature not specified in the publication
0.0000137 - 0.000023
2,6-dichloro-4-[2-(piperazin-1-yl)pyridin-4-yl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
0.00029
2,6-dichloro-4-[6-(piperazin-1-yl)pyridin-3-yl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.001
2,6-dichloro-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.01
2-(acetylamino)-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide
Candida albicans
IC50: above 0.01 mM
0.01
2-(benzylamino)-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide
Candida albicans
IC50: above 0.01 mM
0.01
2-amino-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide
Candida albicans
IC50: above 0.01 mM
1
2-dodecylglycidoyl-S-CoA
Homo sapiens
IC50 below 1 mM
0.0033
2-oxo-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinoline-6-sulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.000046
2-[(2-methylpropanoyl)amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide
Candida albicans
IC50: 0.000046 mM
0.000028
2-[(cyclobutylcarbonyl)amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide
Candida albicans
IC50: 0.000028 mM
0.0000344
2-[(cyclohexanecarbonyl)amino]-N-[(2-naphthylmethyl)amino]ethyl-benzothiazole-6-carboxamide
Candida albicans
IC50: 0.0000344 mM
0.1
2-[(cyclohexylcarbonyl)amino]-1-methyl-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1H-benzimidazole-5-carboxamide
Candida albicans
IC50: above 0.1 mM
0.1
2-[(cyclohexylcarbonyl)amino]-1-methyl-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1H-benzimidazole-6-carboxamide
Candida albicans
IC50: above 0.1 mM
0.0019
2-[(cyclohexylcarbonyl)amino]-N-(3-[[(naphthalen-2-ylmethyl)amino]methyl]benzyl)-1,3-benzothiazole-6-carboxamide
Candida albicans
IC50: 0.0019 mM
0.1
2-[(cyclohexylcarbonyl)amino]-N-(4-[[(naphthalen-2-ylmethyl)amino]methyl]benzyl)-1,3-benzothiazole-6-carboxamide
Candida albicans
IC50: above 0.1 mM
0.0068
2-[(cyclohexylcarbonyl)amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-5-carboxamide
Candida albicans
IC50: 0.0068 mM
0.001
2-[(cyclohexylcarbonyl)amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-7-carboxamide
Candida albicans
IC50: 0.001 mM
0.0011
2-[(cyclohexylcarbonyl)amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzoxazole-5-carboxamide
Candida albicans
IC50: 0.0011 mM
0.00029
2-[(cyclohexylcarbonyl)amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzoxazole-6-carboxamide
Candida albicans
IC50: 0.00029 mM
0.00011
2-[(cyclohexylcarbonyl)amino]-N-[3-[(naphthalen-2-ylmethyl)amino]propyl]-1,3-benzothiazole-6-carboxamide
Candida albicans
IC50: 0.00011 mM
0.000074
2-[(cyclohexylcarbonyl)amino]-N-[4-[(naphthalen-2-ylmethyl)amino]butyl]-1,3-benzothiazole-6-carboxamide
Candida albicans
IC50: 0.000074 mM
0.0003
2-[(cyclohexylcarbonyl)amino]-N-[5-[(naphthalen-2-ylmethyl)amino]pentyl]-1,3-benzothiazole-6-carboxamide
Candida albicans
IC50: 0.0003 mM
0.001
2-[(cyclohexylmethyl)amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide
Candida albicans
IC50: above 0.001 mM
0.000023
2-[(cyclopentylcarbonyl)amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide
Candida albicans
IC50: 0.000023 mM
0.00031
2-[[(2,5-dimethoxyphenyl)carbonyl]amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide
Candida albicans
IC50: 0.00031 mM
0.01
2-[[(2-chloropyridin-3-yl)carbonyl]amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide
Candida albicans
IC50: above 0.01 mM
0.01
2-[[(3,4-dichlorophenyl)carbonyl]amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide
Candida albicans
IC50: above 0.01 mM
0.01
2-[[(4-chlorophenyl)carbonyl]amino]-N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide
Candida albicans
IC50: above 0.01 mM
0.0009
3',5'-dichloro-4'-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfamoyl]biphenyl-3-carboxamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.000005
3,5-dichloro-3'-[(4-methylpiperazin-1-yl)methyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)biphenyl-4-sulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.00002
3,5-dichloro-3'-[(diethylamino)methyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)biphenyl-4-sulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.0012
3,5-dichloro-4'-[(4-methylpiperazin-1-yl)methyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)biphenyl-4-sulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.011
3,5-dichloro-4'-[(diethylamino)methyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)biphenyl-4-sulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.028
3-cyano-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
100
3-tetradecyn-1-ol
Homo sapiens
IC50 above 100 mM
0.0048
4-(1H-pyrazol-1-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.000034
4-bromo-2,6-dichloro-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.1
4-bromo-N-[(1,3,5-trimethyl-1H-pyrazol-4-yl)methyl]benzenesulfonamide
Trypanosoma brucei
-
above, pH 7.4, 22°C
0.032
4-cyano-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.1
4-[(4-bromophenoxy)methyl]-1,3,5-trimethyl-1H-pyrazole
Trypanosoma brucei
-
above, pH 7.4, 22°C
0.042
4-[[(4-bromophenyl)sulfonyl]methyl]-1,3,5-trimethyl-1H-pyrazole
Trypanosoma brucei
-
pH 7.4, 22°C
0.012
6-(2-methyl-1,3-thiazol-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.0013
6-(benzylamino)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.0019
6-(morpholin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.001
6-([2-[4-(propan-2-yl)piperazin-1-yl]ethyl]amino)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.026
6-chloro-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.00033
6-[(1H-indol-5-ylmethyl)amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.00014
6-[2-(4-methylpiperazin-1-yl)ethylamino]pyridine-3-sulfonic acid (1,3,5-trimethyl-1H-pyrazol-4-yl)amide
Trypanosoma brucei
-
pH 7.4, 22°C
0.00003
6-[3-(piperazin-1-yl)piperidin-1-yl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.00011
6-[3-(piperazin-1-yl)pyrrolidin-1-yl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.00003
6-[[2-(1-methylpiperidin-4-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.0013
6-[[2-(1H-imidazol-1-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.01
6-[[2-(4-benzylpiperazin-1-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.00011
6-[[2-(4-methylpiperazin-1-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.001
6-[[2-(4-phenylpiperazin-1-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.038
6-[[2-(morpholin-4-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.001
6-[[2-(piperazin-1-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.014
6-[[2-(piperidin-1-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.0021
6-[[3-(dimethylamino)propyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.00036
6-[[4-[(dimethylamino)methyl]benzyl](methyl)amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.00046
CP-014553
Trypanosoma brucei
IC50: 460 nM
0.00025
CP-030890-27
Trypanosoma brucei
IC50: 250 nM
1
lauric acid
Homo sapiens
IC50 below 1 mM
1
myristelaidic acid
Homo sapiens
IC50 below 1 mM
1 - 100
myristic acid
Homo sapiens
IC50 in the range 1-100 mM
1
myristoleic acid
Homo sapiens
IC50 below 1 mM
1
N(2-S-CoA-tetradecanoyl)glycinamide
Homo sapiens
IC50 below 1 mM
0.012
N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.000024 - 0.0243
N-(10-aminodecanoyl)-L-seryl-N-(2-cyclohexylethyl)-L-lysinamide
0.000349 - 0.000513
N-(11-aminoundecanoyl)-L-seryl-N-(2-cyclohexylethyl)-L-lysinamide
0.1
N-(4-bromobenzyl)-1,3,5-trimethyl-1H-pyrazol-4-amine
Trypanosoma brucei
-
above, pH 7.4, 22°C
0.1
N-(4-bromophenyl)-1,3,5-trimethyl-1H-pyrazole-4-carboxamide
Trypanosoma brucei
-
above, pH 7.4, 22°C
0.1
N-(4-bromophenyl)-1,3,5-trimethyl-1H-pyrazole-4-sulfonamide
Trypanosoma brucei
-
above, pH 7.4, 22°C
0.00016
N-(6-[[N-(biphenyl-4-ylmethyl)-b-alanyl]amino]-1,3-benzothiazol-2-yl)cyclopentanecarboxamide
Candida albicans
IC50: 0.00016 mM
0.00018
N-(6-[[N-(naphthalen-2-ylmethyl)-b-alanyl]amino]-1,3-benzothiazol-2-yl)cyclohexanecarboxamide
Candida albicans
IC50: 0.00018 mM
0.0023
N-(6-[[N-(naphthalen-2-ylmethyl)glycyl]amino]-1,3-benzothiazol-2-yl)cyclohexanecarboxamide
Candida albicans
IC50: 0.0023 mM
0.000059
N-[2-chloro-5-[(3S,4R)-1-[4-(4-chlorophenyl)-3-hydroxybutanoyl]-4-(hydroxymethyl)pyrrolidin-3-yl]phenyl]-2-(4-fluorophenyl)acetamide
Leishmania donovani
pH not specified in the publication, temperature not specified in the publication
0.0000033
N-[2-[(2-methylpropanoyl)amino]-1,3-benzothiazol-6-yl]-3-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide
Candida albicans
IC50: 0.0000033 mM
0.0000023
N-[2-[(cyclobutylcarbonyl)amino]-1,3-benzothiazol-6-yl]-3-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide
Candida albicans
IC50: 0.0000023 mM
0.0000081
N-[2-[(cyclohexylcarbonyl)amino]-1,3-benzothiazol-6-yl]-3-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide
Candida albicans
IC50: 0.0000081 mM
0.0000012
N-[2-[(cyclopentylcarbonyl)amino]-1,3-benzothiazol-6-yl]-3-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide
Candida albicans
IC50: 0.0000012 mM
0.00013
N-[2-[(cyclopentylcarbonyl)amino]-1,3-benzothiazol-6-yl]-3-[[(4-phenylcyclohexa-1,5-dien-1-yl)methyl]amino]cyclohexanecarboxamide
Candida albicans
IC50: 0.00013 mM
0.0000024
N-[2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl]-3-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide
Candida albicans
IC50: 0.0000024 mM
0.01
N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-1,3-benzothiazole-6-carboxamide
Candida albicans
IC50: above 0.01 mM
0.00013
N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-2-(propanoylamino)-1,3-benzothiazole-6-carboxamide
Candida albicans
IC50: 0.00013 mM
0.01
N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-2-([[4-(trifluoromethyl)phenyl]carbonyl]amino)-1,3-benzothiazole-6-carboxamide
Candida albicans
IC50: above 0.01 mM
0.00016
N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-2-[(phenylcarbonyl)amino]-1,3-benzothiazole-6-carboxamide
Candida albicans
IC50: 0.00016 mM
0.00073
N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-2-[(pyrazin-2-ylcarbonyl)amino]-1,3-benzothiazole-6-carboxamide
Candida albicans
IC50: 0.00073 mM
0.01
N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-2-[(pyridin-2-ylcarbonyl)amino]-1,3-benzothiazole-6-carboxamide
Candida albicans
IC50: above 0.01 mM
0.01
N-[2-[(naphthalen-2-ylmethyl)amino]ethyl]-2-[(pyridin-2-ylmethyl)amino]-1,3-benzothiazole-6-carboxamide
Candida albicans
IC50: above 0.01 mM
0.0028
N-[4-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfamoyl]phenyl]acetamide
Trypanosoma brucei
-
pH 7.4, 22°C
0.0000016
N-[5-[(4R)-1-[(3R)-3-amino-4-(4-chlorophenyl)butanoyl]-4-(hydroxymethyl)pyrrolidin-3-yl]-2-chlorophenyl]-2-(4-fluorophenyl)acetamide
Leishmania donovani
pH not specified in the publication, temperature not specified in the publication
0.000065
N-[6-([3-[(naphthalen-2-ylmethyl)amino]azetidin-1-yl]carbonyl)-1,3-benzothiazol-2-yl]cyclohexanecarboxamide
Candida albicans
IC50: 0.000065 mM
0.00021
N-[6-([3-[(naphthalen-2-ylmethyl)amino]piperidin-1-yl]carbonyl)-1,3-benzothiazol-2-yl]cyclohexanecarboxamide
Candida albicans
IC50: 0.00021 mM
0.00019
N-[6-([3-[(naphthalen-2-ylmethyl)amino]pyrrolidin-1-yl]carbonyl)-1,3-benzothiazol-2-yl]cyclohexanecarboxamide
Candida albicans
IC50: 0.00019 mM
0.000015
N-[6-([4-[(naphthalen-2-ylmethyl)amino]butanoyl]amino)-1,3-benzothiazol-2-yl]cyclopentanecarboxamide
Candida albicans
IC50: 0.000015 mM
0.0005
N-[6-([4-[(naphthalen-2-ylmethyl)amino]piperidin-1-yl]carbonyl)-1,3-benzothiazol-2-yl]cyclohexanecarboxamide
Candida albicans
IC50: 0.0005 mM
0.000026
N-[6-[(4-[[(naphthalen-2-ylmethyl)amino]methyl]piperidin-1-yl)carbonyl]-1,3-benzothiazol-2-yl]cyclohexanecarboxamide
Candida albicans
IC50: 0.000026 mM
1 - 100
palmitic acid
Homo sapiens
IC50 in the range 1-100 mM
1
S-(2-bromotetradecanoyl)-CoA
Homo sapiens
IC50 below 1 mM
0.00006
S-(2-ketopentadecyl)-CoA
Homo sapiens
IC50: 0.00006 mM
0.0000687 - 0.0687
S-(2-oxo)pentadecyl-CoA
0.01
tert-butyl 4-[2-([5-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfamoyl]pyridin-2-yl]amino)ethyl]piperazine-1-carboxylate
Trypanosoma brucei
-
pH 7.4, 22°C
0.01
tert-butyl [6-([2-[(naphthalen-2-ylmethyl)amino]ethyl]carbamoyl)-1,3-benzothiazol-2-yl]carbamate
Candida albicans
IC50: above 0.01 mM
100
tetradecyl trimethylammonium bromide
Homo sapiens
IC50 above 100 mM
100
tetradecyl triphenylphosphonium bromide
Homo sapiens
IC50 above 100 mM
0.000034
trans-N-[2-[(cyclopentylcarbonyl)amino]-1,3-benzothiazol-6-yl]-4-[(naphthalen-2-ylmethyl)amino]cyclohexanecarboxamide
Candida albicans
IC50: 0.000034 mM
additional information
additional information
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