Reference on EC 2.3.1.97 - glycylpeptide N-tetradecanoyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Towler, D.A.; Gordon, J.I.; Adams, S.P.; Glaser, L.
The biology and enzymology of eukaryotic protein acylation
Annu. Rev. Biochem.
57
69-99
1988
Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Triticum aestivum
Towler, D.E.; Adams, S.P.; Eubanks, S.R.; Towery, D.S.; Jackson-Machelski, E.; Glaser, L.; Gordon, J.I.
Purification and characterization of yeast myristoyl CoA:protein N-myristoyltransferase [published erratum appears in Proc Natl Acad Sci U S A 1987 Nov;84(21):7523]
Proc. Natl. Acad. Sci. USA
84
2708-2712
1987
Saccharomyces cerevisiae
Heuckeroth, R.O.; Towler, D.A.; Adams, S.P.; Glaser, L.; Gordon, J.I.
11-(Ethylthio)undecanoic acid. A myristic acid analogue of altered hydrophobicity which is functional for peptide N-myristoylation with wheat germ and yeast acyltransferase
J. Biol. Chem.
263
2127-2133
1988
Saccharomyces cerevisiae, Triticum aestivum
King, M.J.; Sharma, R.K.
Identification, purification and characterization of a membrane-associated N-myristoyltransferase inhibitor protein from bovine brain
Biochem. J.
291
635-639
1993
Bos taurus
McIlhinney, R.A.J.; McGlone, K.; Willis, A.C.
Purification and partial sequencing of myristoyl-CoA:protein N-myristoyltransferase from bovine brain
Biochem. J.
290
405-410
1993
Bos taurus
-
Wiegand, R.C.; Carr, C.; Minnerly, J.C.; Pauley, A.M.; Carron, C.P.; Langner, C.A.; Duronio, R.J.; Gordon, J.I.
The Candida albicans myristoyl-CoA:protein N-myristoyltransferase gene. Isolation and expression in Saccharomyces cerevisiae and Escherichia coli
J. Biol. Chem.
267
8591-8598
1992
Saccharomyces cerevisiae, Candida albicans
Rudnick, D.A.; Rocque, W.J.; McWherter, C.A.; Toth, M.V.; Jackson-Machelski, E.; Gordon, J.I.
Use of photoactivatable peptide substrates of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase (Nmt1p) to characterize a myristoyl-CoA-Nmt1p-peptide ternary complex and to provide evidence for an ordered reaction mechanism
Proc. Natl. Acad. Sci. USA
90
1087-1091
1993
Saccharomyces cerevisiae
McIlhenney, R.A.J.; McGlone, K.
Characterization of the myristoyl CoA:glycylpeptide N-myristoyl transferase from rat and bovine brain
Biochem. Soc. Trans.
20
341S
1992
Bos taurus, Rattus norvegicus
Wagner, A.P.; Retey, J.
Synthesis of myristoyl-carba(dethia)-coenzyme A and S-(3-oxohexadecyl)-coenzyme A, two potent inhibitors of myristoyl-CoA: protein N-myristoyltransferase
Eur. J. Biochem.
195
699-705
1991
Saccharomyces cerevisiae
Boutin, J.A.; Clarenc, J.P.; Ferry, G.; Ernould, A.P.; Remond, G.; Vincent, M.; Atassi, G.
N-myristoyl-transferase activity in cancer cells. Solubilization, specificity and enzymatic inhibition of a N-myristoyl transferase from L1210 microsomes
Eur. J. Biochem.
201
257-263
1991
Saccharomyces cerevisiae, Mus musculus, Rattus norvegicus
Kishore, N.S.; Lu, T.; Knoll, L.J.; Katoh, A.; Rudnick, D.A.; Mehta, P.P.; Devadas, B.; Huhn, M.; Atwood, J.L.; Adams, S.P.; Gokel, G.W.; Gordon, J.I.
The substrate specificity of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase. Analysis of myristic acid analogs containing oxygen, sulfur, double bonds, triple bonds, and/or an aromatic residue
J. Biol. Chem.
266
8835-8855
1991
Saccharomyces cerevisiae
Rudnick, D.A.; McWherter, C.A.; Rocaque, W.J.; Lennon, P.J.; Getman, D.P.; Gordon, J.I.
Kinetic and structural evidence for a sequential ordered Bi Bi mechanism of catalysis by Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase
J. Biol. Chem.
266
9732-9739
1991
Saccharomyces cerevisiae
Duronio, R.J.; Rudnick, D.A.; Adams, S.P.; Towler, D.A.; Gordon, J.I.
Analyzing the substrate specificity of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase by co-expressing it with mammalian G protein alpha subunits in Escherichia coli
J. Biol. Chem.
266
10498-10504
1991
Saccharomyces cerevisiae
Gordon, J.I.; Duronio, R.J.; Rudnick, D.A.; Adams, S.P.; Gokel, G.W.
Protein N-myristoylation
J. Biol. Chem.
266
8647-8650
1991
Saccharomyces cerevisiae, no activity in Escherichia coli
Paige, L.A.; Zheng, G.Q.; DeFrees, S.A.; Cassady, J.M.; Geahlen, R.L.
Metabolic activation of 2-substituted derivatives of myristic acid to form potent inhibitors of myristoyl CoA:protein N-myristoyltransferase
Biochemistry
29
10566-10573
1990
Mus musculus
Rudnick, D.A.; McWherter, C.A.; Adams, S.A.; Ropson, I.J.; Duronio, R.J.; Gordon, J.I.
Structural and functional studies of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase produced in Escherichia coli. Evidence for an acyl-enzyme intermediate
J. Biol. Chem.
265
13370-13378
1990
Saccharomyces cerevisiae, no activity in Escherichia coli
McIlhinney, R.A.J.; McGlone, K.
Characterisation of a myristoyl CoA:glycylpeptide N-myristoyl transferase activity in rat brain: subcellular and regional distribution
J. Neurochem.
54
110-117
1990
Rattus norvegicus
Heuckeroth, R.O.; Jackson-Machelski, E.; Adams, S.P.; Kishore, N.S.; Huhn, M.; Katoh, A.; Lu, T.; Gokel, G.W.; Gordon, J.I.
Novel fatty acyl substrates for myristoyl-CoA:protein N-myristoyl-transferase
J. Lipid Res.
31
1121-1129
1990
Saccharomyces cerevisiae
Paige, L.A.; Chafin, D.R.; Cassady, J.M.; Geahlen, R.L.
Detection of myristoyl CoA:protein N-myristoyltransferase activity by ion-exchange chromatography
Anal. Biochem.
181
254-258
1989
Mus musculus
McIlhinney, R.A.J.; McGlone, K.
Characterization, regional and subcellular distribution of an N-myristoyl-CoA:glycyltransferase activity in rat brain
Biochem. Soc. Trans.
17
888-889
1989
Rattus norvegicus
-
Heuckeroth, R.O.; Glaser, L.; Gordon, J.I.
Heteroatom-substituted fatty acid analogs as substrates for N-myristoyltransferase: an approach for studying both the enzymology and function of protein acylation
Proc. Natl. Acad. Sci. USA
85
8795-8799
1988
Saccharomyces cerevisiae, Saccharomyces cerevisiae BJ405
Glover, C.J.; Goddard, C.; Felsted, R.L.
N-myristoylation of p60src. Identification of a myristoyl-CoA:glycylpeptide N-myristoyltransferase in rat tissues
Biochem. J.
250
485-491
1988
Rattus norvegicus
Towler, D.A.; Eubanks, S.R.; Towery, D.S.; Adams, S.P.; Glaser, L.
Amino-terminal processing of proteins by N-myristoylation. Substrate specificity of N-myristoyl transferase
J. Biol. Chem.
262
1030-1036
1987
Saccharomyces cerevisiae, Mus musculus
Towler, D.A.; Adams, S.P.; Eubanks, S.R.; Towery, D.S.; Jackson-Machelski, E.; Glaser, L.; Gordon, J.I.
Myristoyl CoA: protein N-myristoyltransferase activities from rat liver and yeast possess overlapping yet distinct peptide substrate specificities
J. Biol. Chem.
263
1784-1790
1988
Saccharomyces cerevisiae, Rattus norvegicus
Duronio, R.J.; Read, S.I.; Gordon, J.I.
Mutations of human myristoyl-CoA:protein N-myristoyltransferase cause temperature-sensitive myristic acid auxotrophy in Saccharomyces cerevisiae
Proc. Natl. Acad. Sci. USA
89
4129-4133
1992
Homo sapiens
King, M.J.; Sharma, R.K.
Differential activation of bovine brain N-myristoyltransferase(s) by a cytosolic activator
Biochem. Biophys. Res. Commun.
212
580-588
1995
Bos taurus
Lu, T.; Li, Q.; Katoh, A.; Hernandez, J.; Duffin, K.; Jackson-Machelski, E.; Knoll, L.J.; Gokel, G.W.; Gordon, J.I.
The substrate specificity of Saccharomyces cerevisiae myristoyl-CoA: protein N-myristoyltransferase. Polar probes of the enzyme's myristoyl-CoA recognition site
J. Biol. Chem.
269
5346-5357
1994
Saccharomyces cerevisiae
Glover, C.J.; Felsted, R.L.
Identification and characterization of multiple forms of bovine brain N-myristoyltransferase
J. Biol. Chem.
270
23226-23233
1995
Bos taurus
Zhang, L.; Jackson-Machelski, E.; Gordon, J.I.
Biochemical studies of Saccharomyces cerevisiae myristoyl-coenzyme A:protein N-myristoyltransferase mutants
J. Biol. Chem.
271
33131-33140
1996
Saccharomyces cerevisiae
Raju, R.V.S.; Datla, R.S.S.; Sharma, R.K.
Expression of human N-myristoyltransferase in Escherichia coli. Comparison with N-myristoyltransferases expressed in different tissues
Mol. Cell. Biochem.
155
69-76
1996
Homo sapiens
Raju, R.V.S.; Datla, R.S.S.; Kakkarl, R.; Sharma, R.K.
Recombinant bovine spleen myristoyl CoA: protein N-myristoyltransferase
Mol. Cell. Biochem.
189
91-97
1998
Bos taurus
McIlhinney, R.A.J.; McGlone, K.
Immunocytochemical characterization and subcellular localization of human myristoyl-CoA: protein N-myristoyltransferase in HeLa cells
Exp. Cell Res.
223
348-356
1996
Homo sapiens
Young, K.; Egerton, M.; Camble, R.; White, A.; McIlhinney, R.A.J.
Immunochemical characterization of human N-myristoyltransferase: evidence for more than one form of the enzyme
Biochem. Soc. Trans.
25
S631
1997
Homo sapiens
Raju, R.V.S.; Kakkar, R.; Datla, R.S.S.; Radhi, J.; Sharma, R.K.
Myristoyl-CoA:protein N-myristoyltransferase from bovine cardiac muscle: molecular cloning, kinetic analysis, and in vitro proteolytic cleavage by m-calpain
Exp. Cell Res.
241
23-35
1998
Bos taurus
Giang, D.K.; Cravatt, B.F.
A second mammalian N-myristoyltransferase
J. Biol. Chem.
273
6595-6598
1998
Homo sapiens (O60551), Homo sapiens (P30419), Homo sapiens, Mus musculus (O70310), Mus musculus (O70311), Mus musculus
Raju, R.V.S.; Datla, R.S.S.; Warrington, R.C.; Sharma, R.K.
Effects of L-histidine and its structural analogs on human N-myristoyltransferase activity and importance of EEVEH amino acid sequence for enzyme activity
Biochemistry
37
14928-14936
1998
Homo sapiens, Rattus norvegicus
McIlhinney, R.A.; Young, K.; Egerton, M.; Camble, R.; White, A.; Soloviev, M.
Characterization of human and rat brain myristoyl-CoA:protein N-myristoyltransferase: evidence for an alternative splice variant of the enzyme
Biochem. J.
333
491-495
1998
Homo sapiens, Rattus norvegicus
-
Farazi, T.A.; Manchester, J.K.; Gordon, J.I.
Transient-state kinetic analysis of Saccharomyces cerevisiae myristoylCoA:protein N-myristoyltransferase reveals that a step after chemical transformation is rate limiting
Biochemistry
39
15807-15816
2000
Saccharomyces cerevisiae (P14743), Saccharomyces cerevisiae
Qi, Q.; Rajala, R.V.S.; Anderson, W.; Jiang, C.; Rozwadowski, K.; Selvaraj, G.; Sharma, R.; Datla, R.
Molecular cloning, genomic organization, and biochemical characterization of myristoyl-CoA:protein N-myristoyltransferase from Arabidopsis thaliana
J. Biol. Chem.
275
9673-9683
2000
Arabidopsis thaliana (Q9LTR9), Arabidopsis thaliana
Farazi, T.A.; Manchester, J.K.; Waksman, G.; Gordon, J.I.
Pre-steady-state kinetic studies of Saccharomyces cerevisiae myristoylCoA:protein N-myristoyltransferase mutants identify residues involved in catalysis
Biochemistry
40
9177-9186
2001
Saccharomyces cerevisiae
Rundle, D.R.; Rajala, R.V.; Anderson, R.E.
Characterization of Type I and Type II myristoyl-CoA:protein N-myristoyltransferases with the Acyl-CoAs found on heterogeneously acylated retinal proteins
Exp. Eye Res.
75
87-97
2002
Bos taurus
Takamune, N.; Hamada, H.; Sugawara, H.; Misumi, S.; Shoji, S.
Development of an enzyme-linked immunosorbent assay for measurement of activity of myristoyl-coenzyme A:protein N-myristoyltransferase
Anal. Biochem.
309
137-142
2002
Saccharomyces cerevisiae
Sogabe, S.; Masubuchi, M.; Sakata, K.; Fukami, T.A.; Morikami, K.; Shiratori, Y.; Ebiike, H.; Kawasaki, K.; Aoki, Y.; Shimma, N.; D'Arcy, A.; Winkler, F.K.; Banner, D.W.; Ohtsuka, T.
Crystal structures of Candida albicans N-myristoyltransferase with two distinct inhibitors
Chem. Biol.
9
1119-1128
2002
Candida albicans
Pasha, M.K.; Dimmock, J.R.; Hollenberg, M.D.; Sharma, R.K.
Enhanced activity of human N-myristoyltransferase by dimethyl sulfoxide and related solvents in the presence of serine/threonine-containing peptide substrates
Biochem. Pharmacol.
64
1461-1467
2002
Homo sapiens
Farazi, T.A.; Waksman, G.; Gordon, J.I.
Structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoylCoA and peptide provide insights about substrate recognition and catalysis
Biochemistry
40
6335-6343
2001
Saccharomyces cerevisiae (P14743), Saccharomyces cerevisiae
Boisson, B.; Meinnel, T.
A continuous assay of myristoyl-CoA:protein N-myristoyltransferase for proteomic analysis
Anal. Biochem.
322
116-123
2003
Saccharomyces cerevisiae, Arabidopsis thaliana (Q9LTR9), Arabidopsis thaliana
Selvakumar, P.; Lakshmikuttyamma, A.; Lawman, Z.; Bonham, K.; Dimmock, J.R.; Sharma, R.K.
Expression of methionine aminopeptidase 2,N-myristoyltransferase, and N-myristoyltransferase inhibitor protein 71 in HT29
Biochem. Biophys. Res. Commun.
322
1012-1017
2004
Homo sapiens
Shrivastav, A.; Selvakumar, P.; Bajaj, G.; Lu, Y.; Dimmock, J.R.; Sharma, R.K.
Regulation of N-myristoyltransferase by novel inhibitor proteins
Cell Biochem. Biophys.
43
189-202
2005
Rattus norvegicus
Shrivastav, A.; Pasha, M.K.; Selvakumar, P.; Singh, B.; Sharma, R.K.
Expression, localization, and correlation of N-myristoyltransferase and its inhibitor in bovine eye
Invest. Ophthalmol. Vis. Sci.
45
1674-1679
2004
Bos taurus
Price, H.P.; Menon, M.R.; Panethymitaki, C.; Goulding, D.; McKean, P.G.; Smith, D.F.
Myristoyl-CoA:protein N-myristoyltransferase, an essential enzyme and potential drug target in kinetoplastid parasites
J. Biol. Chem.
278
7206-7214
2003
Trypanosoma brucei, Leishmania major (Q9GPZ4), Leishmania major
Yang, S.H.; Shrivastav, A.; Kosinski, C.; Sharma, R.K.; Chen, M.H.; Berthiaume, L.G.; Peters, L.L.; Chuang, P.T.; Young, S.G.; Bergo, M.O.
N-myristoyltransferase 1 is essential in early mouse development
J. Biol. Chem.
280
18990-18995
2005
Mus musculus
Hill, B.T.; Skowronski, J.
Human N-myristoyltransferases form stable complexes with lentiviral nef and other viral and cellular substrate proteins
J. Virol.
79
1133-1141
2005
Homo sapiens
Rundle, D.R.; Rajala, R.V.; Alvarez, R.A.; Anderson, R.E.
Myristoyl-CoA:protein N-myristoyltransferases: isoform identification and gene expression in retina
Mol. Vis.
10
177-185
2004
Bos taurus
Ma, H.H.; Yang, L.; Yang, X.Y.; Xu, Z.P.; Li, B.L.
Bacterial expression, purification, and in vitro N-myristoylation of fusion hepatitis B virus preS1 with the native-type N-terminus
Protein Expr. Purif.
27
49-54
2003
Homo sapiens
Selvakumar, P.; Lakshmikuttyamma, A.; Charavaryamath, C.; Singh, B.; Tuchek, J.; Sharma, R.K.
Expression of myristoyltransferase and its interacting proteins in epilepsy
Biochem. Biophys. Res. Commun.
335
1132-1139
2005
Bos taurus, Saccharomyces cerevisiae, Candida sp. (in: Saccharomycetales), Oryctolagus cuniculus, Dictyostelium sp., Homo sapiens, Mus musculus, Rattus norvegicus
Panethymitaki, C.; Bowyer, P.W.; Price, H.P.; Leatherbarrow, R.J.; Brown, K.A.; Smith, D.F.
Characterization and selective inhibition of myristoyl-CoA:protein N-myristoyltransferase from Trypanosoma brucei and Leishmania major
Biochem. J.
396
277-285
2006
Trypanosoma brucei (Q388H8), Trypanosoma brucei, Leishmania major (Q9GPZ4), Leishmania major
Breuer, S.; Gerlach, H.; Kolaric, B.; Urbanke, C.; Opitz, N.; Geyer, M.
Biochemical indication for myristoylation-dependent conformational changes in HIV-1 Nef
Biochemistry
45
2339-2349
2006
Homo sapiens
Ebara, S.; Naito, H.; Nakazawa, K.; Ishii, F.; Nakamura, M.
FTR1335 is a novel synthetic inhibitor of Candida albicans N-myristoyltransferase with fungicidal activity
Biol. Pharm. Bull.
28
591-595
2005
Candida albicans (P30418), Candida albicans
Yamazaki, K.; Kaneko, Y.; Suwa, K.; Ebara, S.; Nakazawa, K.; Yasuno, K.
Synthesis of potent and selective inhibitors of Candida albicans N-myristoyltransferase based on the benzothiazole structure
Bioorg. Med. Chem.
13
2509-2522
2005
Candida albicans (P30418), Candida albicans, Homo sapiens (P30419)
Selvakumar, P.; Sharma, R.K.
Phosphorylation and dephosphorylation of human myristoyltransferase type 1
Can. J. Physiol. Pharmacol.
84
707-712
2006
Homo sapiens (P30419), Homo sapiens
Selvakumar, P.; Smith-Winsor, E.; Bonham, K.; Sharma, R.K.
N-Myristoyltransferase 2 expression in human colon cancer: Cross-talk between the calpain and caspase system
FEBS Lett.
580
2021-2026
2006
Homo sapiens
Pasha, M.K.; Sharma, R.K.; Rajput, A.H.
Increased myocardial N-myristoyltransferase activity in rotenone model of Parkinsonism
Int. J. Mol. Med.
15
987-991
2005
Rattus norvegicus
Selvakumar, P.; Sharma, R.K.
Role of calpain and caspase system in the regulation of N-myristoyltransferase in human colon cancer (Review)
Int. J. Mol. Med.
19
823-827
2007
Homo sapiens (O60551), Homo sapiens
Ducker, C.E.; Upson, J.J.; French, K.J.; Smith, C.D.
Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis
Mol. Cancer Res.
3
463-476
2005
Homo sapiens (O60551), Homo sapiens (P30419), Homo sapiens
Rioux, V.; Beauchamp, E.; Pedrono, F.; Daval, S.; Molle, D.; Catheline, D.; Legrand, P.
Identification and characterization of recombinant and native rat myristoyl-CoA: protein N-myristoyltransferases
Mol. Cell. Biochem.
286
161-170
2006
Rattus norvegicus (Q700Q7), Rattus norvegicus (Q8K1Q0)
Lu, Y.; Selvakumar, P.; Ali, K.; Shrivastav, A.; Bajaj, G.; Resch, L.; Griebel, R.; Fourney, D.; Meguro, K.; Sharma, R.K.
Expression of N-myristoyltransferase in human brain tumors
Neurochem. Res.
30
9-13
2005
Homo sapiens (O60551), Homo sapiens (P30419), Homo sapiens
Selvakumar, P.; Lakshmikuttyamma, A.; Shrivastav, A.; Das, S.B.; Dimmock, J.R.; Sharma, R.K.
Potential role of N-myristoyltransferase in cancer
Prog. Lipid Res.
46
1-36
2007
Oryctolagus cuniculus, Homo sapiens (O60551), Homo sapiens (P30419), Homo sapiens, Saccharomyces cerevisiae (P14743), Bos taurus (P31717), Bos taurus (Q9N181), Rattus norvegicus (Q8K1Q0)
Heal, W.; Wickramasinghe, S.; Bowyer, P.; Holder, A.; Smith, D.; Leatherbarrow, R.; Tate, E.
Site-specific N-terminal labelling of proteins in vitro and in vivo using N-myristoyl transferase and bioorthogonal ligation chemistry
Chem. Commun. (Camb. )
8
480-482
2008
Candida albicans
-
Bowyer, P.; Tate, E.; Leatherbarrow, R.; Holder, A.; Smith, D.; Brown, K.
N-myristoyltransferase: A prospective drug target for protozoan parasites
ChemMedChem
3
402-408
2008
Candida albicans, Cryptococcus neoformans, Histoplasma capsulatum, Leishmania major, Plasmodium falciparum, Saccharomyces cerevisiae, Trypanosoma brucei
Charavaryamath, C.; Lemieux, H.; Singh Suri, S.; Selvakumar, P.; Sharma, R.K.; Singh, B.
Expression and activities of N-myristoyltransferase and calcineurin in normal and inflamed lungs
Exp. Lung Res.
35
729-747
2009
Rattus norvegicus
Selvakumar, P.; Lakshmikuttyamma, A.; Sharma, R.K.
Biochemical characterization of bovine brain myristoyl-CoA:protein N-myristoyltransferase type 2
J. Biomed. Biotechnol.
2009
907614
2009
Bos taurus (Q9N181), Bos taurus
Sheng, C.; Ji, H.; Miao, Z.; Che, X.; Yao, J.; Wang, W.; Dong, G.; Guo, W.; Lue, J.; Zhang, W.
Homology modeling and molecular dynamics simulation of N-myristoyltransferase from protozoan parasites: active site characterization and insights into rational inhibitor design
J. Comput. Aided Mol. Des.
23
375-389
2009
Trypanosoma brucei, Leishmania major (Q9GPZ4), Leishmania major, Plasmodium falciparum (Q9U419), Plasmodium falciparum
Seaton, K.; Smith, C.
N-Myristoyltransferase isozymes exhibit differential specificity for human immunodeficiency virus type 1 Gag and Nef
J. Gen. Virol.
89
288-296
2008
Homo sapiens (O60551), Homo sapiens (P30419), Homo sapiens
Shrivastav, A.; Varma, S.; Lawman, Z.; Yang, S.H.; Ritchie, S.A.; Bonham, K.; Singh, S.M.; Saxena, A.; Sharma, R.K.
Requirement of N-myristoyltransferase 1 in the development of monocytic lineage
J. Immunol.
180
1019-1028
2008
Homo sapiens, Mus musculus (O70310), Mus musculus (O70311), Mus musculus
Brannigan, J.A.; Smith, B.A.; Yu, Z.; Brzozowski, A.M.; Hodgkinson, M.R.; Maroof, A.; Price, H.P.; Meier, F.; Leatherbarrow, R.J.; Tate, E.W.; Smith, D.F.; Wilkinson, A.J.
N-Myristoyltransferase from Leishmania donovani: Structural and functional characterisation of a potential drug target for visceral leishmaniasis
J. Mol. Biol.
396
985-999
2009
Leishmania donovani (D0AB09), Leishmania donovani, Leishmania donovani LV9 (D0AB09)
Deokar, H.; Puranik, P.; Kulkarni, V.
QSAR analysis of N-myristoyltransferase inhibitors: antifungal activity of benzofurans
Med. Chem. Res.
18
206-220
2009
Candida albicans (P30418)
-
Price, H.P.; Guether, M.L.; Ferguson, M.A.; Smith, D.F.
Myristoyl-CoA:protein N-myristoyltransferase depletion in trypanosomes causes avirulence and endocytic defects
Mol. Biochem. Parasitol.
169
55-58
2010
Trypanosoma brucei
Lakshmikuttyamma, A.; Selvakumar, P.; Tuchek, J.; Sharma, R.
Myristoyltransferase and calcineurin: novel molecular therapeutic target for epilepsy
Prog. Neurobiol.
84
77-84
2008
Homo sapiens
Shrivastav, A.; Suri, S.; Mohr, R.; Janardhan, K.; Sharma, R.; Singh, B.
Expression and activity of N-myristoyltransferase in lung inflammation of cattle and its role in neutrophil apoptosis
Vet. Res.
41
9
2010
Bos taurus
Goncalves, V.; Brannigan, J.A.; Thinon, E.; Olaleye, T.O.; Serwa, R.; Lanzarone, S.; Wilkinson, A.J.; Tate, E.W.; Leatherbarrow, R.J.
A fluorescence-based assay for N-myristoyltransferase activity
Anal. Biochem.
421
342-344
2012
Homo sapiens
Morgan, C.R.; Miglionico, B.V.; Engen, J.R.
Effects of HIV-1 Nef on human N-myristoyltransferase 1
Biochemistry
50
3394-3403
2011
Homo sapiens
Kumar, S.; Singh, B.; Dimmock, J.R.; Sharma, R.K.
N-myristoyltransferase in the leukocytic development processes
Cell Tissue Res.
345
203-211
2011
Homo sapiens, Mus musculus, Rattus norvegicus
Brand, S.; Cleghorn, L.A.; McElroy, S.P.; Robinson, D.A.; Smith, V.C.; Hallyburton, I.; Harrison, J.R.; Norcross, N.R.; Spinks, D.; Bayliss, T.; Norval, S.; Stojanovski, L.; Torrie, L.S.; Frearson, J.A.; Brenk, R.; Fairlamb, A.H.; Ferguson, M.A.; Read, K.D.; Wyatt, P.G.; Gilbert, I.H.
Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors
J. Med. Chem.
55
140-152
2012
Homo sapiens, Trypanosoma brucei
Goncalves, V.; Brannigan, J.A.; Whalley, D.; Ansell, K.H.; Saxty, B.; Holder, A.A.; Wilkinson, A.J.; Tate, E.W.; Leatherbarrow, R.J.
Discovery of Plasmodium vivax N-myristoyltransferase inhibitors: screening, synthesis, and structural characterization of their binding mode
J. Med. Chem.
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Plasmodium vivax
Bell, A.S.; Mills, J.E.; Williams, G.P.; Brannigan, J.A.; Wilkinson, A.J.; Parkinson, T.; Leatherbarrow, R.J.; Tate, E.W.; Holder, A.A.; Smith, D.F.
Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs
PLoS Negl. Trop. Dis.
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Homo sapiens (O60551), Homo sapiens (P30419), Homo sapiens, Leishmania donovani (D0AB09), Leishmania donovani, Plasmodium falciparum (Q8ILW6), Plasmodium falciparum, Trypanosoma brucei (D0A003), Trypanosoma brucei
Fang, W.; Robinson, D.A.; Raimi, O.G.; Blair, D.E.; Harrison, J.R.; Lockhart, D.E.; Torrie, L.S.; Ruda, G.F.; Wyatt, P.G.; Gilbert, I.H.; van Aalten, D.M.
N-myristoyltransferase is a cell wall target in Aspergillus fumigatus
ACS Chem. Biol.
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1425-1434
2015
Aspergillus fumigatus (Q9UVX3), Aspergillus fumigatus, Aspergillus fumigatus ATCC MYA-4609 (Q9UVX3)
Shimada, T.; Suzuki, M.; Katakura, S.
Structure of N-myristoyltransferase from Aspergillus fumigatus
Acta Crystallogr. Sect. D
71
754-761
2015
Aspergillus fumigatus (Q9UVX3), Aspergillus fumigatus, Aspergillus fumigatus ATCC MYA-4609 (Q9UVX3)
Ohta, H.; Takamune, N.; Kishimoto, N.; Shoji, S.; Misumi, S.
N-Myristoyltransferase 1 enhances human immunodeficiency virus replication through regulation of viral RNA expression level
Biochem. Biophys. Res. Commun.
463
988-993
2015
Homo sapiens
Dudek, E.; Millott, R.; Liu, W.X.; Beauchamp, E.; Berthiaume, L.G.; Michalak, M.
N-myristoyltransferase 1 interacts with calnexin at the endoplasmic reticulum
Biochem. Biophys. Res. Commun.
468
889-893
2015
Mus musculus
Roberts, A.J.; Torrie, L.S.; Wyllie, S.; Fairlamb, A.H.
Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase
Biochem. J.
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2014
Trypanosoma cruzi
Wright, M.H.; Paape, D.; Storck, E.M.; Serwa, R.A.; Smith, D.F.; Tate, E.W.
Global analysis of protein N-myristoylation and exploration of N-myristoyltransferase as a drug target in the neglected human pathogen Leishmania donovani
Chem. Biol.
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342-354
2015
Leishmania donovani (D0AB09), Leishmania donovani
Flamm, A.G.; Le Roux, A.L.; Mateos, B.; Diaz-Lobo, M.; Storch, B.; Breuker, K.; Konrat, R.; Pons, M.; Coudevylle, N.
N-Lauroylation during the expression of recombinant N-myristoylated proteins: implications and solutions
ChemBioChem
17
82-89
2016
Homo sapiens
Perinpanayagam, M.; Beauchamp, E.; Martin, D.; Sim, J.; Yap, M.; Berthiaume, L.
Regulation of co-and post-translational myristoylation of proteins during apoptosis: Interplay of N-myristoyltransferases and caspases
FASEB J.
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Homo sapiens
Hutton, J.A.; Goncalves, V.; Brannigan, J.A.; Paape, D.; Wright, M.H.; Waugh, T.M.; Roberts, S.M.; Bell, A.S.; Wilkinson, A.J.; Smith, D.F.; Leatherbarrow, R.J.; Tate, E.W.
Structure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors
J. Med. Chem.
57
8664-8670
2014
Leishmania donovani (D0AB09), Leishmania donovani, Leishmania major (Q4Q5S8), Leishmania major
Rackham, M.; Yu, Z.; Brannigan, J.; Heal, W.; Paape, D.; Barker, K.; Wilkinson, A.; Smith, D.; Leatherbarrow, R.; Tate, E.
Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase
MedChemComm
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1761-1766
2015
Leishmania donovani (D0AB09), Leishmania donovani
Olaleye, T.O.; Brannigan, J.A.; Roberts, S.M.; Leatherbarrow, R.J.; Wilkinson, A.J.; Tate, E.W.
Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites
Org. Biomol. Chem.
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Plasmodium falciparum, Plasmodium vivax (A5K1A2), Leishmania donovani (D0AB09), Homo sapiens (P30419), Homo sapiens, Plasmodium vivax Salvador I (A5K1A2)
Kumar, S.; Sharma, R.
N-terminal region of the catalytic domain of human N-myristoyltransferase 1 acts as an inhibitory module
PLoS ONE
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2015
Homo sapiens (P30419), Homo sapiens
Junqueira, L.; Da Costa, M.; Rando, D.
N-myristoyltransferases as antileishmanial targets A piggyback approach with benzoheterocyclic analogues
Braz. J. Pharm. Sci.
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Candida albicans (P30418), Leishmania major (Q4Q5S8)
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Garcia-Sosa, A.T.
Designing ligands for Leishmania, Plasmodium, and Aspergillus N-myristoyl transferase with specificity and anti-target-safe virtual libraries
Curr. Comput. Aided Drug Des.
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2018
Leishmania major (Q4Q5S8)
Garcia, M.; de Oliveira, A.; Bueno, R.; Nogueira, V.; de Souza, G.; Guido, R.
QSAR studies on benzothiophene derivatives as Plasmodium falciparum N-myristoyltransferase inhibitors Molecular insights into affinity and selectivity
Drug Dev. Res.
2020
1-21
2020
Homo sapiens, Plasmodium falciparum
Soupene, E.; Kao, J.; Cheng, D.; Wang, D.; Greninger, A.; Knudsen, G.; DeRisi, J.; Kuypers, F.
Association of NMT2 with the acyl-CoA carrier ACBD6 protects the N-myristoyltransferase reaction from palmitoyl-CoA
J. Lipid Res.
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2016
Homo sapiens (O60551), Homo sapiens
Bayliss, T.; Robinson, D.A.; Smith, V.C.; Brand, S.; McElroy, S.P.; Torrie, L.S.; Mpamhanga, C.; Norval, S.; Stojanovski, L.; Brenk, R.; Frearson, J.A.; Read, K.D.; Gilbert, I.H.; Wyatt, P.G.
Design and synthesis of brain penetrant trypanocidal N-myristoyltransferase inhibitors
J. Med. Chem.
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Trypanosoma brucei
de Carvalho Gallo, J.; de Mattos Oliveira, L.; Araujo, J.; Santana, I.; dos Santos Junior, M.
Virtual screening to identify Leishmania braziliensis N-myristoyltransferase inhibitors pharmacophore models, docking, and molecular dynamics
J. Mol. Model.
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Leishmania braziliensis
Goncalves, V.; Brannigan, J.; Laporte, A.; Bell, A.; Roberts, S.; Wilkinson, A.; Leatherbarrow, R.; Tate, E.
Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase
MedChemComm
8
191-197
2017
Plasmodium falciparum, Plasmodium vivax (A5K1A2), Plasmodium vivax, Homo sapiens (O60551), Homo sapiens (P30419), Plasmodium vivax Salvador I (A5K1A2)
Taniguchi, C.; Sugawara, T.; Onoue, S.; Kawahara, K.
Structural modification of Escherichia coli lipid A by myristoyltransferase gene from Klebsiella pneumoniae
Microbiol. Immunol.
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2019
Klebsiella pneumoniae
Singh, N.; Shah, P.; Dwivedi, H.; Mishra, S.; Tripathi, R.; Sahasrabuddhe, A.A.; Siddiqi, M.I.
Integrated machine learning, molecular docking and 3D-QSAR based approach for identification of potential inhibitors of trypanosomal N-myristoyltransferase
Mol. Biosyst.
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3711-3723
2016
Leishmania donovani, Trypanosoma brucei
Mousnier, A.; Bell, A.S.; Swieboda, D.P.; Morales-Sanfrutos, J.; Perez-Dorado, I.; Brannigan, J.A.; Newman, J.; Ritzefeld, M.; Hutton, J.A.; Guedan, A.; Asfor, A.S.; Robinson, S.W.; Hopkins-Navratilova, I.; Wilkinson, A.J.; Johnston, S.L.; Leatherbarrow, R.J.; Tuthill, T.J.; Solari, R.; Tate, E.W.
Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus
Nat. Chem.
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599-606
2018
Homo sapiens (O60551), Homo sapiens (P30419), Homo sapiens
Dian, C.; Perez-Dorado, I.; Riviere, F.; Asensio, T.; Legrand, P.; Ritzefeld, M.; Shen, M.; Cota, E.; Meinnel, T.; Tate, E.; Giglione, C.
High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation
Nat. Commun.
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1132
2020
Homo sapiens (P30419), Homo sapiens
Corbic Ramljak, I.; Stanger, J.; Real-Hohn, A.; Dreier, D.; Wimmer, L.; Redlberger-Fritz, M.; Fischl, W.; Klingel, K.; Mihovilovic, M.D.; Blaas, D.; Kowalski, H.
Cellular N-myristoyltransferases play a crucial picornavirus genus-specific role in viral assembly, virion maturation, and infectivity
PLoS Pathog.
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e1007203
2018
Homo sapiens (P30419), Homo sapiens
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