2.3.3.5: 2-methylcitrate synthase
This is an abbreviated version!
For detailed information about 2-methylcitrate synthase, go to the full flat file.
Word Map on EC 2.3.3.5
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2.3.3.5
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propionate
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propionyl-coa
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dehydratase
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acetyl-coa
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3-hydroxyvalerate
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mcsa
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methylisocitrate
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polyhydroxyalkanoates
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methylmalonyl-coa
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propionyl
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eutropha
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halomonas
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paracoccidioidomycosis
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odd-chain
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drug development
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lutzii
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paracoccidioides
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coa-transferase
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prpbcde
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butyryl-coa
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medicine
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agriculture
- 2.3.3.5
- propionate
- propionyl-coa
- dehydratase
- acetyl-coa
- 3-hydroxyvalerate
- mcsa
- methylisocitrate
- polyhydroxyalkanoates
- methylmalonyl-coa
-
propionyl
- eutropha
- halomonas
-
paracoccidioidomycosis
-
odd-chain
- drug development
- lutzii
- paracoccidioides
-
coa-transferase
-
prpbcde
- butyryl-coa
- medicine
- agriculture
Reaction
Synonyms
2-MC synthase, 2-MCS, 2-MCS1, 2-methylcitrate oxaloacetate-lyase, 2-methylcitrate synthase 2, citrate synthase II, citrate synthase/2-methylcitrate synthase, EC 4.1.3.31, MCA condensing enzyme, MCS, Mcs1, mcsA, Methylcitrate synthase, methylcitrate synthetase, mmgD, MscA, PrpC, prpC2, Rv1131
ECTree
2.3.3.5 2-methylcitrate synthaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.3.3.5 - 2-methylcitrate synthase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
propanoyl-CoA + H2O + oxaloacetate
(2S,3S)-2-methylcitrate + CoA
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reaction is followed by isomerization of (2S,3S)-2-methylcitrate, i.e. (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate, to (2R,3S)-2-methylisocitrate, i.e. (2R,3S)-2-hydroxybutane-1,2,3-tricarboxylate, via cis-2-methylaconitate, key enzyme in the methylcitrate cycle for alpha-oxidation of propionate to pyruvate, overview
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ir
acetyl-CoA + H2O + oxaloacetate
citrate + CoA
bifunctional enzyme with 2.3-fold higher activity as a 2-methylcitrate synthase
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-
?
acetyl-CoA + H2O + oxaloacetate
citrate + CoA
bifunctional enzyme with 2.3-fold higher activity as a 2-methylcitrate synthase
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-
?
propanoyl-CoA + H2O + oxaloacetate
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
the fungi-specific 2-methylcitrate cycle is responsible for detoxifying propionyl-CoA, a toxic metabolite produced as the fungus breaks down proteins and amino acids. The enzyme responsible for this detoxification is 2-methylcitrate synthase (mcsA) and is a potential candidate for the design of new anti-fungals
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?
propanoyl-CoA + H2O + oxaloacetate
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
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?
propanoyl-CoA + H2O + oxaloacetate
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
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-
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?
propanoyl-CoA + H2O + oxaloacetate
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
bifunctional enzyme with 2.3-fold higher activity as a 2-methylcitrate synthase (reaction of EC 2.3.3.16)
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?
propanoyl-CoA + H2O + oxaloacetate
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
bifunctional enzyme with 2.3-fold higher activity as a 2-methylcitrate synthase (reaction of EC 2.3.3.16)
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-
?
propanoyl-CoA + H2O + oxaloacetate
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
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-
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?
propanoyl-CoA + H2O + oxaloacetate
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
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-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
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the enzyme is involved in the 2-methylcitrate cycle pathway which plays a significant role in the detoxification of propionyl-CoA in bacteria
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?
propanoyl-CoA + H2O + oxaloacetate
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
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the enzyme is specific to the methylcitrate cycle and essential for mycobacteria to grow on propionate as the sole carbon source
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?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
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?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
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-
-
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?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
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-
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?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
first key enzyme of the methylcitric acid cycle
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?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
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-
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?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
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-
-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
-
first key enzyme of the methylcitric acid cycle
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-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
first key enzyme of the methylcitric acid cycle
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-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
first key enzyme of the methylcitric acid cycle
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-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
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-
-
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?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
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-
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?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
-
first key enzyme of the methylcitric acid cycle
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-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
first key enzyme of the methylcitric acid cycle
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-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
first key enzyme of the methylcitric acid cycle
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-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
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implicated in the metabolism of propionate
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?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
implicated in the metabolism of propionate
-
-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
first key enzyme of the methylcitric acid cycle
-
-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
implicated in the metabolism of propionate
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-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
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-
-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
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-
-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
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-
-
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?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
-
first key enzyme of the methylcitric acid cycle
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-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
-
implicated in the metabolism of propionate
-
-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
-
first key enzyme of the methylcitric acid cycle
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-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
-
implicated in the metabolism of propionate
-
-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
-
first key enzyme of the methylcitric acid cycle
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-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
first key enzyme of the methylcitric acid cycle
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-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
-
first key enzyme of the methylcitric acid cycle
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-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
-
first key enzyme of the methylcitric acid cycle
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-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
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-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
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-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
-
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
-
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
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-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
-
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
-
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
-
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
-
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
-
first key enzyme of the methylcitric acid cycle
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-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
-
2-methylcitrate pathway is the major pathway of propionate metabolism
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?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
-
2-methylcitrate pathway is the major pathway of propionate metabolism
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?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
-
first key enzyme of the methylcitric acid cycle
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-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
-
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
-
first key enzyme of the methylcitric acid cycle
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-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
first key enzyme of the methylcitric acid cycle
-
-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
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-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
-
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
-
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
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-
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?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
-
physiological role of the methylcitric acid cycle is a catabolic reaction sequence concerning the oxidation of propionate into pyruvate, regulatory enzyme of this cycle
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?
propanoyl-CoA + H2O + oxaloacetate
2-methylcitrate + CoA
-
first key enzyme of the methylcitric acid cycle
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?
propionyl-CoA + H2O + oxaloacetate
(2R,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
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-
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?
propionyl-CoA + H2O + oxaloacetate
(2R,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
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-
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?
propionyl-CoA + H2O + oxaloacetate
(2R,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
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?
propionyl-CoA + H2O + oxaloacetate
(2R,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
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?
additional information
?
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key enzyme of the methylcitrate cycle and required for fungal propionate degradation
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?
additional information
?
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key enzyme of the methylcitrate cycle and required for fungal propionate degradation
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?
