2.4.1.174: glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase

This is an abbreviated version!
For detailed information about glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase, go to the full flat file.

Reaction

Synonyms

acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-chondroitin, I, ChGn-1, ChGn-2, chondroitin beta1,4-N-acetylgalactosaminyltransferase-1, chondroitin galactosaminyltransferase, chondroitin N-acetylgalactosaminyltransferase-1, chondroitin N-acetylgalactosaminyltransferase-2, chondroitin sulfate beta-1,4-N-acetylgalactosaminyltransferase-1 ChGn-1, chondroitin sulfate N-acetylgalactosaminyltransferase 1, chondroitin sulfate N-acetylgalactosaminyltransferase 2, chondroitin sulfate N-acetylgalactosaminyltransferase-1, chondroitin sulfate N-acetylgalactosaminyltransferase-2, chondroitin sulfate synthase 1, chondroitin sulfate synthase-1, chondroitin sulphate N-acetylgalactosaminyl-transferase-1, chondroitin sulphate N-acetylgalactosaminyltransferase 1, CHSY1, CS N-acetylgalactosaminyltransferase 1, CS N-acetylgalactosaminyltransferase-1, CSGal-NACT-1, CSGalNAcT-1, CSGalNAcT1, CSGALNACT2, CSS1, GalNAcT-I, GalNAcT-II, glucuronylgalactosylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase, More, N-acetylgalactosamineT-II, N-acetylgalactosaminyltransferase I, uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase I

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.174 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase

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Results	in table
9	AA Sequence
2	Application
1	CAS Registry Number
21	Cloned(Commentary)
32	Disease/ Diagnostics
6	Expression
67	General Information
39	Inhibitors
10	Localization
5	Metals/Ions
3	Molecular Weight [Da]
20	Natural Substrates/ Products (Substrates)
110	Organism
5	Pathway
5	pH Optimum
2	Posttranslational Modification
26	Protein Variants
2	Purification (Commentary)
2	Reaction
1	Reaction Type
35	Reference
112	Source Tissue
2	Specific Activity [micromol/min/mg]
42	Substrates and Products (Substrate)
3	Subunits
83	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Temperature Stability [°C]

Disease

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Disease on EC 2.4.1.174 - glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Carcinogenesis

Glycosyltransferase expression in human colonic tissue examined by oligonucleotide arrays.

12787925

Carcinoma

Glycosylation is an Androgen-Regulated Process Essential for Prostate Cancer Cell Viability.

27428423

Hepatitis C

Design and Synthesis of Cajanine Analogues against Hepatitis C Virus through Down-Regulating Host Chondroitin Sulfate N-Acetylgalactosaminyltransferase 1.

27783522

Hereditary Sensory and Motor Neuropathy

Chondroitin beta-1,4-N-acetylgalactosaminyltransferase-1 missense mutations are associated with neuropathies.

21160489

Infections

Chondroitin sulfate N-acetylgalactosaminyltransferase-2 contributes to the replication of infectious bursal disease virus via interaction with the capsid protein VP2.

25807054

Intervertebral Disc Degeneration

Upregulation of glycosaminoglycan synthesis by Neurotropin in nucleus pulposus cells via stimulation of chondroitin sulfate N-acetylgalactosaminyltransferase 1: A new approach to attenuation of intervertebral disc degeneration.

30148873

Joint Instability

Biallelic CSGALNACT1-mutations cause a mild skeletal dysplasia.

31325655

Joint Instability

Chondroitin Sulfate N-acetylgalactosaminylTransferase-1 (CSGalNAcT-1) Deficiency Results in a Mild Skeletal Dysplasia and Joint Laxity.

27599773

Kashin-Beck Disease

Abnormal expression of chondroitin sulphate N-acetylgalactosaminyltransferase 1 and Hapln-1 in cartilage with Kashin-Beck disease and primary osteoarthritis.

23748413

Language Development Disorders

CSGALNACT1-congenital disorder of glycosylation: A mild skeletal dysplasia with advanced bone age.

31705726

Neoplasm Metastasis

Glycosyltransferase expression in human colonic tissue examined by oligonucleotide arrays.

12787925

Neoplasms

Polymorphisms Within the RET Proto-Oncogene and Risk of Sporadic Medullary Thyroid Carcinoma.

32228166

Osteoarthritis

Abnormal expression of chondroitin sulphate N-acetylgalactosaminyltransferase 1 and Hapln-1 in cartilage with Kashin-Beck disease and primary osteoarthritis.

23748413

Polyneuropathies

Chondroitin beta-1,4-N-acetylgalactosaminyltransferase-1 missense mutations are associated with neuropathies.

21160489

Prostatic Neoplasms

Glycosylation is a global target for androgen control in prostate cancer cells.

28159857

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