2.4.1.41: polypeptide N-acetylgalactosaminyltransferase

This is an abbreviated version!
For detailed information about polypeptide N-acetylgalactosaminyltransferase, go to the full flat file.

Word Map on EC 2.4.1.41

2.4.1.41

o-glycosylation

mucin-type

mucin

glycosyltransferase

o-glycans

o-linked

threonine

gangliosides

lectin

calcinosis

oligosaccharide

metastasis

calcification

hyperphosphatemic

gm2

galactosyltransferase

glycolipids

1,25-dihydroxyvitamin

phosphaturic

gd1a

sialyltransferase

submaxillary

angptl3

mucin-like

klotho

hyperostosis

muc5ac

factor-23

apomucin

analysis

drug development

lutropin

asn-linked

molecular biology

periarticular

medicine

o-glycoproteins

iga1

villosa

Reaction

UDP-N-acetyl-alpha-D-galactosamine

+

[protein]-L-serine

=

UDP

+

[protein]-3-O-(N-acetyl-alpha-D-galactosaminyl)-L-serine

Synonyms

(UDP)-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-glycoprotein, bgibmga008904, dGalNAc-T3, Eg-ppGalNAc-T1, GalNAc transferase, GalNAc-T, GalNAc-T1, GalNAc-T11, GalNAc-T12, GalNAc-T13, GalNAc-T14, GalNAc-T16, GalNAc-T18, GalNAc-T2, GalNAc-T3, GalNAc-T4, GalNAc-T5, GalNAc-T6, GalNAc-T7, GalNAc-transferase, GalNAc-transferase T1, GalNAc-transferase T2, GalNAcT4, GALNT1, GALNT11, GALNT12, Galnt13, GALNT14, Galnt18, GALNT2, GALNT3, Galnt4, GalNT5, glycopeptide-preferring polypeptide GalNAc transferase 10, glycoprotein acetylgalactosaminyltransferase, More, N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase, N-acetylgalactosaminyltransferase, N-acetylgalactosaminyltransferase-like 1, NM_001079884, PGANT, PGANT1, PGANT2, PGANT3, PGANT4, PGANT5, PGANT6, PGANT7, PGANT8, polypeptide GalNAc transferase, polypeptide GalNAc transferase 2, polypeptide GalNAc-transferase, polypeptide GalNAc-transferase 2, polypeptide GalNAc-transferase-2, polypeptide GalNAcT, polypeptide N-acetylgalactosaminyl transferase-3, polypeptide N-acetylgalactosaminyltransferase, polypeptide N-acetylgalactosaminyltransferase 12, polypeptide N-acetylgalactosaminyltransferase 14, polypeptide N-acetylgalactosaminyltransferase 2, polypeptide N-acetylgalactosaminyltransferase 3, polypeptide N-acetylgalactosaminyltransferase 6, polypeptide N-acetylgalactosaminyltransferase-1, polypeptide-N-acetylgalactosamine transferase, polyppetide GalNAc transferase, pp-GalNAc-T13, pp-GalNAc-T15, pp-GalNAc-T2, pp-GaNTase, ppGalNAc T1, ppGalNAc T10, ppGalNAc T13, ppGalNAc T16, ppGalNAc T2, ppGalNAc T3, ppGalNAc T5, ppGalNAc T6, ppGalNAc-T, ppGalNAc-T1, ppGalNAc-T10, ppGalNAc-T12, ppGalNAc-T2, ppGalNAc-T3, ppGalNAc-T4, ppGalNAc-T5, ppGalNAc-T6, ppGalNAcT, ppGalNAcT or hT, ppGaNTase, ppGaNTase-T1, ppGaNTase-T11, ppGaNTase-T12, ppGaNTase-T3, ppGaNTase-T4, ppGaNTase-T5, ppGaNTase-T6, protein-UDP acetylgalactosaminyltransferase, UDP GalNAc:polypeptide N-acetylgalactosaminyltransferase, UDP N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyl transferase, UDP N-acetyl-alpha-Dgalactosamine:polypeptide N-acetylgalactosaminyl transferase, UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase, UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase, UDP-GalNAc polypeptide:GalNAc transferase-T2, UDP-GalNAc polypeptide:N-acetylgalactosaminyltransferase, UDP-GalNAc polypeptides:N-acetyl-alpha-galactosaminyltransferase, UDP-GalNAc transferase, UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase, UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase-2, UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase-T1, UDP-GalNAc:polypeptide alphaN-acetylgalactosaminyltransferase, UDP-GalNAc:polypeptide GalNAc transferase, UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 18, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 9, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-T3, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13V1, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 17, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 18, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 19, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 20, UDP-N-acetyl-alpha-D-galactosaminyltransferase, UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-6, UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-T1, UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-T10, UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-T3, UDP-N-acetylgalactosamine polypeptide: N-acetylgalactosaminyl-transferase, UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase, UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase, UDP-N-acetylgalactosamine:kappa-casein polypeptide N-acetylgalactosaminyltransferase, UDP-N-acetylgalactosamine:polypeptide N-acetyl-alpha-galactosaminyltransferase, UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase, UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase, UDP-N-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase, UDP-polypeptide N-acetylgalactosaminyl transferase, uridine diphosphate-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3, uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase, xGaltnl-1

ECTree

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.41 polypeptide N-acetylgalactosaminyltransferase

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Results	in table
6	Activating Compound
996	AA Sequence
18	Application
1	CAS Registry Number
75	Cloned(Commentary)
15	Crystallization (Commentary)
1566	Disease/ Diagnostics
7	Expression
24	General Information
5	General Stability
47	IC50 Value
63	Inhibitors
3	kcat/KM [mM/s]
9	Ki Value [mM]
201	KM Value [mM]
58	Localization
60	Metals/Ions
26	Molecular Weight [Da]
74	Natural Substrates/ Products (Substrates)
158	Organism
5	Pathway
48	PDB ID
18	pH Optimum
3	pH Range
10	Posttranslational Modification
112	Protein Variants
49	Purification (Commentary)
3	Reaction
11	Reaction Type
142	Reference
320	Source Tissue
85	Specific Activity [micromol/min/mg]
7	Storage Stability
569	Substrates and Products (Substrate)
11	Subunits
296	Synonyms
1	Systematic Name
37	Temperature Optimum [°C]
2	Temperature Range [°C]
5	Temperature Stability [°C]
42	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 2.4.1.41 - polypeptide N-acetylgalactosaminyltransferase

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10

benzyl N-acetyl-alpha-D-galactosamine

Homo sapiens

-

acetylated wild type enzyme, at pH 7.4 and 37°C

1 - 20

benzyl-alpha-GalNAc

show

50

D-galactose

Homo sapiens

Q10471, Q10472, Q8N4A0, Q8NCW6

GalNAc-MUC1 binding to biotinylated GalNAc-T4

1 - 37

GalNAc

show

50

methyl-alpha-Gal

Homo sapiens

Q10471, Q10472, Q8N4A0, Q8NCW6

GalNAc-MUC1 binding to biotinylated GalNAc-T4

40

methyl-beta-Gal

Homo sapiens

Q10471, Q10472, Q8N4A0, Q8NCW6

GalNAc-MUC1 binding to biotinylated GalNAc-T4

15 - 20

N-acetyl-alpha-D-galactosamine

show

0.5 - 12

o-nitrophenyl-alpha-GalNAc

show

1 - 12

o-nitrophenyl-beta-GalNAc

show

8

ortho-nitrophenyl-beta-GalNAc

Homo sapiens

Q10471, Q10472, Q8N4A0, Q8NCW6

GalNAc-MUC1 binding to biotinylated GalNAc-T4 lectin domain

1 - 10

p-nitrophenyl-alpha-GalNAc

show

0.8 - 10

p-nitrophenyl-beta-GalNAc

show

10

para-nitrophenyl-alpha-GalNAc

Homo sapiens

Q10471, Q10472, Q8N4A0, Q8NCW6

GalNAc-MUC1 binding to biotinylated GalNAc-T4 lectin domain

1 - 15

phenyl-alpha-GalNAc

show

30 - 65

UDP-alpha-GalNAc

show

additional information

additional information

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Release 2023.1 (January 2023)