2.4.2.28: S-methyl-5'-thioadenosine phosphorylase

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For detailed information about S-methyl-5'-thioadenosine phosphorylase, go to the full flat file.

Reaction

Synonyms

5'-deoxy-5'-methylthioadenosine phosphorylase, 5'-deoxy-5'-methylthioadenosine phosphorylase II, 5'-deoxy-5'-methylthioadenosine:orthophosphate methylthioribosyltransferase, 5'-methylthioadenosine nucleosidase, 5'-methylthioadenosine phosphorylase, 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, 5-methylthioadenosine phosphorylase, 5�-methylthioadenosine phosphorylase, MeSAdo phosphorylase, MeSAdo/Ado phosphorylase, methylthioadenosine nucleosidase, methylthioadenosine nucleoside phosphorylase, methylthioadenosine phosphorylase, MTA phosphorylase, MTAN, MTAN1, MTAN2, MTAP, Mtap protein, MTAPase, MTN1, MTN2, PfMTAP, phosphorylase, methylthioadenosine, RSFP, Rv0535, SsMTAP, SsMTAP II, SsMTAPII, SSO2343

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.2 Pentosyltransferases

                2.4.2.28 S-methyl-5'-thioadenosine phosphorylase

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Results	in table
12	Activating Compound
9873	AA Sequence
10	Application
1	CAS Registry Number
33	Cloned(Commentary)
15	Crystallization (Commentary)
738	Disease/ Diagnostics
3	Expression
13	General Information
13	General Stability
10	IC50 Value
146	Inhibitors
38	kcat/KM [mM/s]
68	Ki Value [mM]
119	KM Value [mM]
7	Localization
3	Metals/Ions
35	Molecular Weight [Da]
44	Natural Substrates/ Products (Substrates)
19	Organic Solvent Stability
267	Organism
1	Oxidation Stability
6	Pathway
177	PDB ID
22	pH Optimum
5	pH Range
1	pH Stability
2	pI Value
53	Protein Variants
39	Purification (Commentary)
16	Reaction
1	Reaction Type
92	Reference
1	Renatured (Commentary)
116	Source Tissue
49	Specific Activity [micromol/min/mg]
8	Storage Stability
229	Substrates and Products (Substrate)
40	Subunits
130	Synonyms
1	Systematic Name
36	Temperature Optimum [°C]
10	Temperature Range [°C]
54	Temperature Stability [°C]
77	Turnover Number [1/s]

pH Range

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pH Range on EC 2.4.2.28 - S-methyl-5'-thioadenosine phosphorylase

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

5 - 10

Saccharolobus solfataricus

P50389

-

637544

6 - 9

Caldariella acidophila

-

50% of activity maximum at pH 6.0 and pH 9.0

637527

6.2 - 8.6

Homo sapiens

-

50% of activity maximum at pH 6.2 and pH 8.6

637542

6.5 - 8.5

Rattus norvegicus

-

considerable decrease of activity below pH 6.5 and above pH 8.5

637526

6.5 - 9

Mycobacterium tuberculosis

O06401

pH 6.5: about 55% of maximal activity, pH 9.0: about 55% of maximal activity

723794