2.4.2.3: uridine phosphorylase
This is an abbreviated version!
For detailed information about uridine phosphorylase, go to the full flat file.
Word Map on EC 2.4.2.3
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2.4.2.3
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pyrimidine
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nucleoside
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thymidine
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uracil
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5-fluorouracil
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phosphorolysis
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salvage
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orotate
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phosphoribosyltransferase
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phosphorylases
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thymidylate
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fluoropyrimidine
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udp
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5'-deoxy-5-fluorouridine
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5-fluoro-2'-deoxyuridine
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dihydropyrimidine
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acyclonucleoside
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5-fluorouridine
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ribose-1-phosphate
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capecitabine
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5-methyluridine
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dthdpase
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fdurd
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orotidine
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dihydrouracil
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uridine-cytidine
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mete
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diagnostics
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medicine
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synthesis
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drug development
- 2.4.2.3
- pyrimidine
- nucleoside
- thymidine
- uracil
- 5-fluorouracil
-
phosphorolysis
-
salvage
- orotate
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phosphoribosyltransferase
- phosphorylases
- thymidylate
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fluoropyrimidine
- udp
- 5'-deoxy-5-fluorouridine
- 5-fluoro-2'-deoxyuridine
- dihydropyrimidine
- acyclonucleoside
- 5-fluorouridine
- ribose-1-phosphate
- capecitabine
- 5-methyluridine
- dthdpase
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fdurd
- orotidine
- dihydrouracil
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uridine-cytidine
-
mete
- diagnostics
- medicine
- synthesis
- drug development
Reaction
Synonyms
apUP, EC 2.4.2.23, L-UrdPase, More, PcUP1, PcUP2, phosphorylase, uridine, pynpase, pyrimidine nucleoside phosphorylase, pyrimidine phosphorylase, pyrimidine/purine nucleoside phosphorylase, StUPh, udp, UDRPase
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 2.4.2.3 - uridine phosphorylase
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REACTION DIAGRAM
5-methyluridine + phosphate
5-methyluracil + alpha-D-ribose 1-phosphate
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-
-
-
r
pyrimidine nucleoside + phosphate
pyrimidine base + alpha-D-ribose 1-phosphate
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most pyrimidine nucleosides except for 4-amino-substituted species like deoxycytidine
or alpha-D-deoxyribose 1-phosphate
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r
uracil + alpha-D-ribose 1-phosphate
uridine + phosphate
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uridine prevents the glucose deprivation-induced death of immunostimulated astrocytes via the action of uridine phosphorylase
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-
?
uridine + phosphate
uracil + alpha-D-ribose 1-phosphate
key enzyme in pyrimidine-salvage pathway
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-
?
uridine + phosphate
uracil + alpha-D-ribose 1-phosphate
-
-
-
-
?
uridine + phosphate
uracil + alpha-D-ribose 1-phosphate
-
enzyme of pyrimidine salvage pathway
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-
?
uridine + phosphate
uracil + alpha-D-ribose 1-phosphate
-
-
-
r
uridine + phosphate
uracil + alpha-D-ribose 1-phosphate
-
-
-
r
uridine + phosphate
uracil + alpha-D-ribose 1-phosphate
-
in conjunction with uridine kinase, the enzyme provides a route for the conversion of uracil to UMP via uridine
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-
?
uridine + phosphate
uracil + alpha-D-ribose 1-phosphate
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role in degradation of pyrimidine nucleosides as well as in the salvage pathway for nucleic acid synthesis
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-
?
uridine + phosphate
uracil + alpha-D-ribose 1-phosphate
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-
-
-
?
uridine + phosphate
uracil + alpha-D-ribose 1-phosphate
-
enzyme of pyrimidine salvage pathway
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-
?
uridine + phosphate
uracil + alpha-D-ribose 1-phosphate
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-
-
?
uridine + phosphate
uracil + alpha-D-ribose 1-phosphate
Shewanella oneidensis MR-1 / ATCC 700550
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-
-
?
uridine + phosphate
uracil + alpha-D-ribose 1-phosphate
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-
-
-
?
uridine + phosphate
uracil + alpha-D-ribose 1-phosphate
-
-
-
?
?
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-
catalyzes the first step of uridine degradation to beta-alanine in liver
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-
?
additional information
?
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UPP catalyzes the reversible phosphorolysis of uracil ribosides and analogous compounds to their respective nucleobases and ribose-1-phosphate, structural mechanisms, overview
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-
?
additional information
?
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UPP catalyzes the reversible phosphorolysis of uracil ribosides and analogous compounds to their respective nucleobases and ribose-1-phosphate, structural mechanisms, overview
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-
?
additional information
?
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the enzyme is regulated by multiple lipid-sensing nuclear receptors, gene expression is diurnally regulated
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-
?
additional information
?
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catalyzes the first step of uridine degradation to beta-alanine in liver
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-
?
additional information
?
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the enzyme also activates pyrimidine-containing drugs, including 5-fluorouracil, mechanism of the enzyme-drug interaction, overview
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-
?