2.7.1.145: deoxynucleoside kinase
This is an abbreviated version!
For detailed information about deoxynucleoside kinase, go to the full flat file.
Word Map on EC 2.7.1.145
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2.7.1.145
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thymidine
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drosophila
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deoxycytidine
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suicide
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deoxyguanosine
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herpes
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medicine
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deoxyadenosine
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e-5-2-bromovinyl-2'-deoxyuridine
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kinase-deficient
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dttp
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deoxythymidine
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dado
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1-beta-d-arabinofuranosylthymine
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synthesis
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agriculture
- 2.7.1.145
- thymidine
- drosophila
- deoxycytidine
-
suicide
- deoxyguanosine
-
herpes
- medicine
- deoxyadenosine
-
e-5-2-bromovinyl-2'-deoxyuridine
-
kinase-deficient
- dttp
- deoxythymidine
-
dado
- 1-beta-d-arabinofuranosylthymine
- synthesis
- agriculture
Reaction
Synonyms
AGCK, AgdNK, BmdNK, D. melanogaster deoxynucleoside kinase, deoxyribonucleoside kinase, deoxyribonucleoside kinase
ECTree
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General Information
General Information on EC 2.7.1.145 - deoxynucleoside kinase
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evolution
physiological function
additional information
evolution of dNKs, overview. The two families of dNKs, the TK1-like kinases and the non-TK1-like kinases, have overall unique monomer structures and only share significant protein sequence similarity at the Ploop, a glycine rich ATP binding domain close to the N-terminus. This suggests that the two families have different evolutionary origins. The insect dNK is a non-TK1 like kinase
evolution
evolution of dNKs, overview. The two families of dNKs, the TK1-like kinases and the non-TK1-like kinases, have overall unique monomer structures and only share significant protein sequence similarity at the Ploop, a glycine rich ATP binding domain close to the N-terminus. This suggests that the two families have different evolutionary origins. The insect dNK is a non-TK1 like kinase
evolution
evolution of dNKs, overview. The two families of dNKs, the TK1-like kinases and the non-TK1-like kinases, have overall unique monomer structures and only share significant protein sequence similarity at the Ploop, a glycine rich ATP binding domain close to the N-terminus. This suggests that the two families have different evolutionary origins. The insect dNK is a non-TK1 like kinase
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dNK expression increases substantially sensitivity of cells to 5-aza-2'-deoxycytidine and 2'-deoxy-zebularine
physiological function
DmdNK is cell cycle regulated and under the control of cyclin E and the dE2F1 transcription factor, involved in G1/S phase transition
physiological function
no differences between mutant cytosolic Dm-dNK, mitochondrial Dm-dNK, and wild-type nuclear Dm-dNK in regards to enzyme activity, cellular sensitivity to nucleoside analogues, or bystander cell killing. Tan IIA may influence the bystander effect of cancer cells expressing Dm-dNK by regulating the expression of Cx43 and Cx26. Tanshinone (Tan) IIA is a fat-soluble and pharmacologically active ingredient of Danshen, a traditional Chinese medicine used in the treatment of cardiovascular diseases. It is isolated from the rhizome of a Chinese herb Salvia miltiorrhiza. Tan IIA treatment of osteosarcoma cells results in the upregulation of Cx43 and Cx26 proteins
physiological function
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the enzyme is involved in chloroplast development
enzyme identification using a mutagenic nucleoside analogue 2-hydroxy-2'-deoxyadenosine 5'-monophosphate, overview. Method development and evaluation for in vivo evolution selection method for active deoxyribonucleoside kinase proteins, including selection of antibiotic-resistant colonies resulting frommutations by phosphorylated 2-hydroxy-deoxyadenosine and the subsequent isolation of the plasmid DNAs. Fifteen Dm-dNK mutants selected after the seventh and eighth evolutioncycles are actually active in vivo, one shows activity similar to the wild-typ enzyme
additional information
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enzyme identification using a mutagenic nucleoside analogue 2-hydroxy-2'-deoxyadenosine 5'-monophosphate, overview. Method development and evaluation for in vivo evolution selection method for active deoxyribonucleoside kinase proteins, including selection of antibiotic-resistant colonies resulting frommutations by phosphorylated 2-hydroxy-deoxyadenosine and the subsequent isolation of the plasmid DNAs. Fifteen Dm-dNK mutants selected after the seventh and eighth evolutioncycles are actually active in vivo, one shows activity similar to the wild-typ enzyme
additional information
structure of non-TK1 like kinases, overview