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2.7.1.39: homoserine kinase

This is an abbreviated version!
For detailed information about homoserine kinase, go to the full flat file.

Word Map on EC 2.7.1.39

Reaction

ATP
+
L-homoserine
=
ADP
 +
O-phospho-L-homoserine

Synonyms

CglThrB, CThrB, DMR1, homoserine kinase, homoserine kinase (phosphorylating), HSK, kinase (phosphorylating), homoserine, kinase, homoserine (phosphorylating), Thr1, Thr1p, ThrB

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.39 homoserine kinase

KI Value

KI Value on EC 2.7.1.39 - homoserine kinase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.012
(2Z)-2-cyano-N-(2,5-dibromophenyl)-3-hydroxybut-2-enamide
-
in 50 mM HEPES, pH 7.5, 40 mM KCl, 10 mM MgCl2, at 37°C
0.2 - 0.5
(4R)-4-hydroxypentan-2-one
-
wild-type enzyme
0.032
1-(naphthalen-2-yl)prop-2-en-1-one
-
in 50 mM HEPES, pH 7.5, 40 mM KCl, 10 mM MgCl2, at 37°C
0.0358
2-(2-methylpropyl)-6,7,8,9-tetrahydro-4H,5H-cyclohepta[4,5]thieno[2,3-d][1,3]oxazin-4-one
-
in 50 mM HEPES, pH 7.5, 40 mM KCl, 10 mM MgCl2, at 37°C
0.0271
2-(3,4-dihydroxyphenyl)-3,6,7-trihydroxy-2,3-dihydro-4H-chromen-4-one
-
in 50 mM HEPES, pH 7.5, 40 mM KCl, 10 mM MgCl2, at 37°C
0.3
2-amino-3-(phosphonoethyl)thiopropionate
-
wild-type enzyme
10.4
2-amino-5-phosphovalerate
-
-
15
2-chloro-L-alanine
-
pH 7.8, 37°C
0.0086
3-methyl-1-phenyl-6-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-4-ol
-
in 50 mM HEPES, pH 7.5, 40 mM KCl, 10 mM MgCl2, at 37°C
0.00046
4-hydroxy-3-[(4-hydroxy-2-oxo-3,8a-dihydro-2H-chromen-3-yl)methyl]-2H-chromen-2-one
-
in 50 mM HEPES, pH 7.5, 40 mM KCl, 10 mM MgCl2, at 37°C
0.9
5'-adenylylimidodiphosphate
-
pH 7.4
0.4
L-2-aminobutyrate
-
pH 7.8, 37°C
0.15
L-alpha-aminobutyric acid
-
-
0.46 - 1
L-Cys
0.2 - 0.5
L-Glutamic acid
-
wild-type enzyme
4
L-homocysteine
-
pH 7.8, 37°C
0.1 - 3
L-homoserine
0.9 - 4.5
L-Ile
35
L-Met
-
pH 7.8, 37°C
0.2 - 0.5
L-norvaline
-
wild-type enzyme
4.3
L-Orn
-
pH 8.5
27
L-Ser
-
pH 7.8, 37°C
0.3 - 1
L-Thr
0.9 - 10
L-Val
2.7
O-phospho-L-serine
-
-
additional information
additional information
-
-
-