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1.1.1.34: hydroxymethylglutaryl-CoA reductase (NADPH)

This is an abbreviated version!
For detailed information about hydroxymethylglutaryl-CoA reductase (NADPH), go to the full flat file.

Word Map on EC 1.1.1.34

Reaction

(R)-mevalonate
+
CoA
 + 2 NADP+ =
(S)-3-hydroxy-3-methylglutaryl-CoA
 + 2 NADPH + 2 H+

Synonyms

3-hydroxy-3-methyl-glutaryl CoA reductase, 3-hydroxy-3-methylglutaryl Ccoenzyme A reductase 1, 3-hydroxy-3-methylglutaryl co-enzyme A reductase, 3-hydroxy-3-methylglutaryl CoA reductase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, 3-hydroxy-3-methylglutaryl coenzyme A reductase 1, 3-hydroxy-3-methylglutaryl-CoA reductase, 3-hydroxy-3-methylglutaryl-CoA reductase (NADPH), 3-hydroxy-3-methylglutaryl-CoA reductase 1, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase 5, 3-hydroxy-3-metylglutaryl coenzyme A reductase, 3-hydroxymethylglutaryl coenzyme A reductase, acetoacetyl-coenzyme A thiolase/3-hydroxy-3-methylglutaryl-coenzyme A reductase, beta-hydroxy-beta-methylglutaryl coenzyme A reductase, beta-hydroxy-beta-methylglutaryl-Co A reductase, EuHMGR, HMG CoA reductase, HMG-CoA reductase, HMG-CoA-R, HMG-CoAR, HMG1, HMG2, HMG2.2, Hmg2p, HMG3.3, HMGCoA reductase, HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating CoA), HMGCoAR, HMGCR, HMGCR1, HMGR, HMGR1, HMGR1S, HMGR2, HMGR3, HMGR5, hydroxy-3-methylglutoryl-Coenzyme A reductase, hydroxymethylglutaryl CoA reductase (NADPH), hydroxymethylglutaryl-coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate), mevalonate:NADP+ oxidoreductase (acetylating CoA), microsomal HMG-CoA reductase, NADPH-hydroxymethylglutaryl-CoA reductase, S-3-hydroxy-3-methylglutaryl-CoA reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH)

Expression

Expression on EC 1.1.1.34 - hydroxymethylglutaryl-CoA reductase (NADPH)

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
after oxidative stress treatment with 0.1 mM methyl viologen, the expression level of isoform HMGR5 is up-regulated significantly at 24 h
-
at 8 h after cold treatment, the transcription level of isoform HMGR3 sharply increases to a peak value that is 4.5fold that of the control. Isoform HMGR3 expression reaches the maximum value, which is 1.67fold that of the control at 4 days after treatment with methyl jasmonate. Abscisic acid treatment shows similarly increasing values until a moderate peak at 2 days after treatment. Salicylic acid and ethanol treatments distinctly upregulated the expression of isoform HMGR3 with the peak appearing at 5 days after treatment. The former increases the expression by 3.74fold and the latter by 34.6fold compared with that of the control
enzyme expression is increased 6 h after treatment with 0.2 mM abscisic acid, 6 h after treatment with 200 mM NaCl, 3 days after treatment with 10% (w/v) PEG 6000, 1 h after treatment with 2 mM H2O2, and 7 days after cold treatment at 4°C
expression of 3-hydroxy-3-metylglutaryl coenzyme A reductase is down-regulated by methyl jasmonate treatment
-
increased Hmgcr mRNA levels after serum starvation
increased Hmgcr mRNA levels after serum starvation are suppressed by 25-hydroxycholesterol. The suppressive effect of 25-hydroxycholesterol on mRNA transcription is ameliorated by trichostatin A. Anacardic acid, 25-hydroxycholesterol and 24(S)-hydroxycholesterol suppress the transcription by inhibiting H3K27 acetylation in the promoter. 27-Hydroxycholesterol, 22(S)-hydroxycholesterol and 22(R)-hydroxycholesterol suppress the transcription
rubber yields and/or yield characteristics are significantly positively correlated with enzyme expression levels
the expression level of isoform HMGR3 is considerably downregulated under dark treatment, that is, 8% of the control at 24 h after treatment
the isoform HMGR2 expression is substantially depressed under dark treatment and is 90% lower than that of the control at 8 h after treatment. Methyl jasmonate treatment causes the continuous downregulation of isoform HMGR2 transcription level at 5% that of the control at 4 days after treatment. The expression level of isoform HMGR2 is downregulated in response to abscisic acid treatment, yielding a value 90% lower than that of the control at 5 days after treatment
under cold treatment, the isoform HMGR2 expression is enhanced by 6.6fold compared with that of the control, and reaches the highest level at 48 h. Under salicylic acid treatment, the expression level of isoform HMGR2 initially decreases first and then increases, and the value is 80% higher than that of the control at 3 days after treatment. Ethanol treatment induces the transcript of isoform HMGR2, which continually increases and reaches the highest expression value at 978% higher than that of the control at 4 days after treatment