1.1.5.12: D-lactate dehydrogenase (quinone)

This is an abbreviated version, for detailed information about D-lactate dehydrogenase (quinone), go to the full flat file.

Reaction

(R)-lactate
+
a quinone
=
pyruvate
+
a quinol

Synonyms

Cg1027, DLD, quinone-dependent D-lactate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.5 With a quinone or similar compound as acceptor
                1.1.5.12 D-lactate dehydrogenase (quinone)

Inhibitors

Inhibitors on EC 1.1.5.12 - D-lactate dehydrogenase (quinone)

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-hydroxy-3-butynoic acid
-
inactivation
-
cyanide
-
stimulates D-lactate dehydrogenase activity at neutral pH, though it inhibits the activity at alkaline pH. At 1.5 mM, 50% inhibition at pH 9.3
additional information
-
not inhibited by 4-chloromercuribenzoate, N-ethylmaleimide, or 5,5'-dithiobis(2-nitrobenzoic acid)
-