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1.14.13.135: 1-hydroxy-2-naphthoate hydroxylase

This is an abbreviated version!
For detailed information about 1-hydroxy-2-naphthoate hydroxylase, go to the full flat file.

Reaction

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1-hydroxy-2-naphthoate
+
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NAD(P)H
+
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H+
+
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O2
=
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1,2-dihydroxynaphthalene
+
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NAD(P)+
+
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H2O
+
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CO2

Synonyms

1-hydroxy-2-naphthoic acid hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                EC 1.14.13.1351.14.13.135 1-hydroxy-2-naphthoate hydroxylase

Natural Substrates Products

Natural Substrates Products on EC 1.14.13.135 - 1-hydroxy-2-naphthoate hydroxylase

for references in articles please use BRENDA:EC1.14.13.135

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY hide
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
1-hydroxy-2-naphthoate + NAD(P)H + O2
1,2-dihydroxynaphthalene + NAD(P)+ + H2O + CO2
show the reaction diagram
1-hydroxy-2-naphthoate + NADH + O2
1,2-dihydroxynaphthalene + NAD+ + H2O + CO2
show the reaction diagram
-
Substrates: a flavoprotein monooxygenase specific for 1-hydroxy-2-naphthoic acid, no activity with any other hydroxynaphthoic acid analogues, o-phthalic acid, 3,4-dihydroxybenzoic acid, or salicylic acid. In the naphthalene route, 1-hydroxy-2-naphthoic acid is metabolized via 1,2-dihydroxynaphthalene and salicylic acid to catechol by a series of enzymatic steps similar to naphthalene metabolic pathway
Products: -
?
1-hydroxy-2-naphthoate + NADPH + O2
1,2-dihydroxynaphthalene + NADP+ + H2O + CO2
show the reaction diagram
-
Substrates: a flavoprotein monooxygenase specific for 1-hydroxy-2-naphthoic acid, no activity with any other hydroxynaphthoic acid analogues, o-phthalic acid, 3,4-dihydroxybenzoic acid, or salicylic acid
Products: -
?