1.14.13.135: 1-hydroxy-2-naphthoate hydroxylase

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For detailed information about 1-hydroxy-2-naphthoate hydroxylase, go to the full flat file.

Reaction

Synonyms

1-hydroxy-2-naphthoic acid hydroxylase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

1.14.13.135 1-hydroxy-2-naphthoate hydroxylase

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Natural Substrates Products on EC 1.14.13.135 - 1-hydroxy-2-naphthoate hydroxylase

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1-hydroxy-2-naphthoate + NAD(P)H + O2

1,2-dihydroxynaphthalene + NAD(P)+ + H2O + CO2

2 entries

1-hydroxy-2-naphthoate + NADH + O2

1,2-dihydroxynaphthalene + NAD+ + H2O + CO2

Alcaligenes sp.

a flavoprotein monooxygenase specific for 1-hydroxy-2-naphthoic acid, no activity with any other hydroxynaphthoic acid analogues, o-phthalic acid, 3,4-dihydroxybenzoic acid, or salicylic acid. In the naphthalene route, 1-hydroxy-2-naphthoic acid is metabolized via 1,2-dihydroxynaphthalene and salicylic acid to catechol by a series of enzymatic steps similar to naphthalene metabolic pathway

712039

1-hydroxy-2-naphthoate + NADPH + O2

1,2-dihydroxynaphthalene + NADP+ + H2O + CO2

Alcaligenes sp.

a flavoprotein monooxygenase specific for 1-hydroxy-2-naphthoic acid, no activity with any other hydroxynaphthoic acid analogues, o-phthalic acid, 3,4-dihydroxybenzoic acid, or salicylic acid

712039