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1.14.14.32: 17alpha-hydroxyprogesterone deacetylase

This is an abbreviated version!
For detailed information about 17alpha-hydroxyprogesterone deacetylase, go to the full flat file.

Word Map on EC 1.14.14.32

Reaction

17alpha-hydroxypregnenolone
+
[reduced NADPH-hemoprotein reductase]
 +
O2
=
3beta-hydroxyandrost-5-en-17-one
 +
acetate
 +
[oxidized NADPH-hemoprotein reductase]
 +
H2O

Synonyms

17,20 lyase, 17-20 lyase, 17-alpha-hydroxylase/C17-20 lyase, 17-hydroxylase/C17,20-lyase, 17alpha-hydroxylase, 17alpha-hydroxylase-C(17,20)-lyase, 17alpha-hydroxylase-C17,20-lyase, 17alpha-hydroxylase/17,20 lyase, 17alpha-hydroxylase/17,20-lyase, 17alpha-hydroxylase/17,20-lyase cytochrome P450, 17alpha-hydroxylase/C(17,20)-lyase, 17alpha-hydroxylase/C17,20-lyase, 17alpha-hydroxyprogesterone aldolase, 17alpha-hydroxyprogesterone aldolase/17,20-lyase, 17alpha-lyase, Adrenal 17,20-lyase, aldolase, 17alpha-hydroxyprogesterone, C-17,20 lyase, C-17/C-20 lyase, C17(20) lyase, C17,20 lyase, C17,20-lyase, CYP17, CYP17A1, cytochrome P450 17, cytochrome P450 17A1, cytochrome P450 17alpha-hydroxylase/17,20-lyase, cytochrome p450 17alpha-hydroxylase/C(17,20)-lyase, cytochrome P450c17, EC 4.1.2.30, P-45017alpha, P450 17A1, P45017alpha, P450c17, P450c17-I, steroid 17alphahydroxylase/17,20-lyase, Steroid C17(20) lyase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.32 17alpha-hydroxyprogesterone deacetylase

IC50 Value

IC50 Value on EC 1.14.14.32 - 17alpha-hydroxyprogesterone deacetylase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.014
(17beta)-17-[(5R)-2-(2-chlorophenyl)-4,5-dihydro-1,3-oxazol-5-yl]androst-4-en-3-one
Rattus norvegicus
-
37°C
0.0048
(17beta)-17-[(5R)-2-(3-chlorophenyl)-4,5-dihydro-1,3-oxazol-5-yl]androst-4-en-3-one
Rattus norvegicus
-
37°C
0.005
(17beta)-17-[(5R)-2-(4-bromophenyl)-4,5-dihydro-1,3-oxazol-5-yl]androst-4-en-3-one
Rattus norvegicus
-
37°C
0.052
(17beta)-17-[(5R)-2-(4-chlorophenyl)-4,5-dihydro-1,3-oxazol-5-yl]androst-4-en-3-one
Rattus norvegicus
-
37°C
0.0077
(17beta)-17-[(5R)-2-(4-nitrophenyl)-4,5-dihydro-1,3-oxazol-5-yl]androst-4-en-3-one
Rattus norvegicus
-
37°C
0.03
(17beta)-17-[(5R)-2-phenyl-4,5-dihydro-1,3-oxazol-5-yl]androst-4-en-3-one
Rattus norvegicus
-
37°C
0.026
(2S,4aR,4bS,6aS,6bR,7S,9aS,10aS,10bS)-4a,6a,7-trimethyl-2,3,4,4a,4b,5,6,6a,6b,7,9,9a,10,10a,10b,11-hexadecahydro-1H-naphtho[2',1':4,5]indeno[2,1-c][1,2]oxazol-2-ol
Rattus norvegicus
-
37°C
0.0058
(2S,4aR,4bS,6aS,6bS,7S,10aS,10bS)-4a,6a,7-trimethyl-8-(4-methylphenyl)-1,2,3,4,4a,4b,5,6,6a,6b,7,8,10,10a,10b,11-hexadecahydronaphtho[2',1':4,5]indeno[2,1-c]pyrazol-2-ol
Rattus norvegicus
-
37°C
0.011
(3beta,17beta)-17-[(5R)-2-(3-chlorophenyl)-4,5-dihydro-1,3-oxazol-5-yl]androst-5-en-3-ol
Rattus norvegicus
-
37°C
0.0079
(3beta,17beta)-17-[(5R)-2-(4-nitrophenyl)-4,5-dihydro-1,3-oxazol-5-yl]androst-5-en-3-ol
Rattus norvegicus
-
37°C
0.0048
(5'R)-17beta-[2-(2-chlorophenyl)-4,5-dihydrooxazol-5-yl]androst-5-en-3-one
Rattus norvegicus
-
pH 7.3, 37°C
0.014
(5'R)-17beta-[2-(3-chlorophenyl)-4,5-dihydrooxazol-5-yl]androst-5-en-3-one
Rattus norvegicus
-
pH 7.3, 37°C
0.005
(5'R)-17beta-[2-(4-bromophenyl)-4,5-dihydrooxazol-5-yl]androst-5-en-3-one
Rattus norvegicus
-
pH 7.3, 37°C
0.052
(5'R)-17beta-[2-(4-chlorophenyl)-4,5-dihydrooxazol-5-yl]androst-5-en-3-one
Rattus norvegicus
-
pH 7.3, 37°C
0.0077
(5'R)-17beta-[2-(4-nitrophenyl)-4,5-dihydrooxazol-5-yl]androst-5-en-3-one
Rattus norvegicus
-
pH 7.3, 37°C
0.0079
(5'R)-17beta-[2-(4-nitrophenyl)-4,5-dihydrooxazol-5-yl]androst-5-en-3beta-ol
Rattus norvegicus
-
pH 7.3, 37°C
0.03
(5'R)-17beta-[2-phenyl-4,5-dihydrooxazol-5-yl]androst-5-en-3-one
Rattus norvegicus
-
pH 7.3, 37°C
0.00614 - 0.03095
1-(3-phenylpropyl)-1H-imidazole
0.00285 - 0.01655
1-(4-bromobenzyl)-1H-imidazole
0.00158 - 0.01006
1-(4-iodo-benzyl)-1H-imidazole
0.00223 - 0.00865
1-(4-phenylbutyl)-1H-imidazole
0.00131 - 0.0022
1-(5-phenylpentyl)-1H-imidazole
0.0001 - 0.00032
1-(7-phenyl-heptyl)-1H-imidazole
0.00033 - 0.00295
1-[3-(4-bromo-phenyl)-propyl]-1H-imidazole
0.00055 - 0.00585
1-[3-(4-chlorophenyl)-propyl]-1H-imidazole
0.00196 - 0.02781
1-[3-(4-fluorophenyl)-propyl]-1H-imidazole
0.000058 - 0.0005
1-[5-(4-bromo-phenyl)-pentyl]-1H-imidazole
0.000086 - 0.00057
1-[5-(4-chlorophenyl)-pentyl]-1H-imidazole
0.0001 - 0.00075
1-[5-(4-fluorophenyl)-pentyl]-1H-imidazole
0.000057 - 0.00017
1-[7-(4-fluorophenyl)-heptyl]-1H-imidazole
0.014
17(E)-picolinyliden-androst-4-en-3beta-ol
Rattus norvegicus
-
C17,20-lyase activity, pH 7.3, 37°C
0.0082
17(E)-picolinyliden-androst-5-en-3beta-ol
Rattus norvegicus
-
C17,20-lyase activity, pH 7.3, 37°C
0.022
17beta-(1-p-cyanophenyl-3-pyrazolyl)androst-4-en-3-one
0.059
17beta-(1-p-methoxyphenyl-3-pyrazolyl)androst-4-en-3-one
Rattus norvegicus
-
-
0.059
17beta-(1-phenyl-5-pyrazolyl)androst-4-en-3-one
Rattus norvegicus
-
pH and temperature not specified in the publication
0.003
17beta-(2-oxazolidon-5-yl)-androst-4-en-3-one
Rattus norvegicus
-
-
0.013
2'-[[(E)-3beta-hydroxyandrost-5-en-17-ylidene]methyl]-4',4'-dimethyl-4',5'-dihydro-1',3'-oxazole
Homo sapiens
-
at pH 7.4 and 37°C
0.0009
2'-[[(E)-3beta-hydroxyandrost-5-en-17-ylidene]methyl]-4',5'-dihydro-1',3'-oxazole
Homo sapiens
-
at pH 7.4 and 37°C
0.00006
3beta-hydroxy-17-(50-[30-methyl]-10,20,40-oxadiazolyl)androst-5,16-diene
Rattus norvegicus
-
pH 7.3, 37°C
0.0002908
4-(1H-imidazol-1-ylmethyl)phenyl 4-(trifluoromethyl)benzenesulfonate
Rattus norvegicus
-
at 37°C
0.0000704
4-(1H-imidazol-1-ylmethyl)phenyl 4-bromobenzenesulfonate
Rattus norvegicus
-
at 37°C
0.0000987
4-(1H-imidazol-1-ylmethyl)phenyl 4-chlorobenzenesulfonate
Rattus norvegicus
-
at 37°C
0.00021
4-(1H-imidazol-1-ylmethyl)phenyl 4-fluorobenzenesulfonate
Rattus norvegicus
-
at 37°C
0.0000651
4-(1H-imidazol-1-ylmethyl)phenyl 4-iodobenzenesulfonate
Rattus norvegicus
-
at 37°C
0.0001009
4-(1H-imidazol-1-ylmethyl)phenyl 4-methoxybenzenesulfonate
Rattus norvegicus
-
at 37°C
0.000085
4-(1H-imidazol-1-ylmethyl)phenyl 4-nitrobenzenesulfonate
Rattus norvegicus
-
at 37°C
0.00023
4-(1H-imidazol-1-ylmethylphenyl)-4-toluenesulfonate
Rattus norvegicus
-
at 37°C
0.00158
4-iodobenzyl imidazole
Rattus norvegicus
-
at 37°C
0.0000012 - 0.0013
abiraterone
0.014
diethylstilbestrol
Sus scrofa
-
adrenal cortex microsomes, pH and temperature not specified in the publication
0.000084
dioctyltin chloride
Homo sapiens
H295R cell assay, pH and temperature not specified in the publication
0.00013 - 0.016
flusilazole
0.000032 - 0.00376
ketoconazole
0.02 - 2
methylmercury
Sus scrofa
-
adrenal cortex microsomes, pH and temperature not specified in the publication
0.000039 - 0.000061
SU10603
0.00014
tebuconazole
Sus scrofa
-
adrenal cortex microsomes, pH and temperature not specified in the publication
0.093
tetrabromobisphenol A
Sus scrofa
-
adrenal cortex microsomes, pH and temperature not specified in the publication