1.2.1.41: glutamate-5-semialdehyde dehydrogenase

This is an abbreviated version!
For detailed information about glutamate-5-semialdehyde dehydrogenase, go to the full flat file.

Word Map on EC 1.2.1.41

Reaction

L-glutamyl 5-phosphate
+
NADPH
+
H+
=
L-glutamate 5-semialdehyde
+
phosphate
+
NADP+

Synonyms

Aldh18a1, ALDH4, beta-glutamylphosphate reductase, dehydrogenase, glutamate semialdehyde, gamma glutamyl semialdehyde dehydrogenase, gamma-glutamyl phosphate reductase, gamma-GPR, GGSALDH, glutamate 5-semialdehyde dehydrogenase, glutamate semialdehyde dehydrogenase, Glutamate-5-semialdehyde dehydrogenase, glutamate-gamma-semialdehyde dehydrogenase, glutamic gamma-semialdehyde dehydrogenase, glutamic-gamma-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GPR, GSA dehydrogenase, OsALDH18-1, P5CS, pyrroline 5-carboxylate dehydrogenase, pyrroline-5-carboxylate synthase, pyrroline-5-carboxylate synthetase, reductase, gamma-glutamyl phosphate

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.41 glutamate-5-semialdehyde dehydrogenase

Reference

Reference on EC 1.2.1.41 - glutamate-5-semialdehyde dehydrogenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kramer, J.J.; Gooding, R.C.; Jones, M.E.
A radiochemical assay for a NADP+-specific gamma-glutamate semialdehyde dehydrogenase extracted from mitochondrial membrane of rat intestinal epithelial cells
Anal. Biochem.
168
380-386
1988
Rattus norvegicus
Manually annotated by BRENDA team
Kramer, J.J.; Henslee, J.G.; Wakabayashi, Y.; Jones, M.E.
Glutamate semialdehyde dehydrogenase
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
3
200-210
1983
Rattus norvegicus
-
Manually annotated by BRENDA team
Deutch, A.H.; Smith, C.J.; Rushlow, K.E.
Overproduction and purification of the three enzymes constituting the Escherichia coli proline biosynthetic pathway
Dev. Ind. Microbiol.
26
437-444
1985
Escherichia coli
-
Manually annotated by BRENDA team
Deutch, A.H.; Rushlow, K.E.; Smith, C.J.
Analysis of the Escherichia coli proBA locus by DNA and protein sequencing
Nucleic Acids Res.
12
6337-6355
1984
Escherichia coli
Manually annotated by BRENDA team
Mahan, M.J.; Csonka, L.N.
Genetic analysis of the proBA genes of Salmonella typhimurium: physical and genetic analyses of the cloned proB+ A+ genes of Escherichia coli and of a mutant allele that confers proline overproduction and enhanced osmotolerance
J. Bacteriol.
156
1249-1262
1983
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Hayzer, D.J.; Leisinger, T.
Proline biosynthesis in Escherichia coli. Kinetic and mechanistic properties of glutamate semialdehyde dehydrogenase
Biochim. Biophys. Acta
742
391-398
1983
Escherichia coli
Manually annotated by BRENDA team
Hayzer, D.J.; Leisinger, T.
Proline biosynthesis in Escherichia coli. Purification and characterisation of glutamate-semialdehyde dehydrogenase
Eur. J. Biochem.
121
561-565
1982
Escherichia coli, Pseudomonas aeruginosa
Manually annotated by BRENDA team
Hayzer, D.J.; Leisinger, T.
Proline biosynthesis in Escherichia coli. Stoichiometry and end-product identification of the reaction catalysed by glutamate semialdehyde dehydrogenase
Biochem. J.
197
269-274
1981
Escherichia coli
Manually annotated by BRENDA team
Hayzer, D.J.; Moses, V.
The enzymes of proline biosynthesis in Escherichia coli. Their molecular weights and the problem of enzyme aggregation
Biochem. J.
173
219-228
1978
Escherichia coli
Manually annotated by BRENDA team
Gamper, H.; Moses, V.
Enzyme organization in the proline biosynthetic pathway of Escherichia coli
Biochim. Biophys. Acta
354
75-87
1974
Escherichia coli
Manually annotated by BRENDA team
Baich, A.
The biosynthesis of proline in Escherichia coli: phosphate-dependent glutamate-semialdehyde dehydrogenase (NADP), the second enzyme in the pathway
Biochim. Biophys. Acta
244
129-134
1971
Escherichia coli, Escherichia coli 55-I
Manually annotated by BRENDA team
Garcia-Rios, M; Fujita, T.; Larosa, P.C.; Locy, R.D.; Clitero, J.M.; Bressan, R.A.; Csonka, L.N.
Cloning of a polycistronic cDNA from tomato encoding gamma-glutamyl kinase and gamma-glutamyl phosphate reductase
Proc. Natl. Acad. Sci. USA
94
8249-8254
1997
Solanum lycopersicum
Manually annotated by BRENDA team
Yaklichkin, S.Y.; Zimina, M.S.; Neumyvakin, L.V.
Proline biosynthesis gene proB of thermophilic Bacterium Thermus ruber: cloning, sequencing, and properties of encoded gamma-glutamylphosphate kinase
Mol. Biol.
33
628-635
1999
Meiothermus ruber
-
Manually annotated by BRENDA team
Louie, H.; Chan.V.L.
Cloning and characterization of the gamma-glutamylphosphate reductase gene of Campylobacter jejuni
Mol. Gen. Genet.
240
29-35
1993
Campylobacter jejuni, Campylobacter jejuni TGH9011
Manually annotated by BRENDA team
Meijer, P.J.; Lilius, G.; Holmberg, N.; Bulow, L
An artificial bifunctional enzyme, gamma-glutamyl kinase/gamma-glutamyl phosphate reductase, improves NaCl tolerance when expressed in Escherichia Coli
Biotechnol. Lett.
18
1133-1138
1996
Escherichia coli
-
Manually annotated by BRENDA team
Page, R.; Nelson, M.S.; von Delft, F.; Elsliger, M.a.; Canaves, J.M.; Brinen, L.S.; Dai, X.; Deacon, A.M.; Floyd, R.; Godzik, A.; Grittini, C.; Grzechnik, S.K.; Jaroszewski, L.; Klock, H.E.; Koesema, E.; Kovarik, J.S.; Kreusch, A.; Kuhn, P.; Lesley, S.A.; McMullan, D.; McPhillips, T.M.; Miller, M.D.; Morse, A.; Moy, K.; Ouyang, J.; Robb, A.; Rodrigues, K.; Schwarzenbacher, R.; Spraggon, G.; Stevens, R.C.; van den Bedem, H.; Velasquez, J.; Vincent, J.; Wang, X.; West, B.; Wolf, G.; Hodgson, K.O.; Wooley, J.; Wilson, I.A.
Crystal structure of gamma-glutamyl phosphate reductase (TM0293) from Thermotoga maritima at 2.0 A resolution
Proteins
54
157-161
2003
Thermotoga maritima (Q9WYC9), Thermotoga maritima
Manually annotated by BRENDA team
Takagi, H.; Takaoka, M.; Kawaguchi, A.; Kubo, Y.
Effect of L-proline on sake brewing and ethanol stress in Saccharomyces cerevisiae
Appl. Environ. Microbiol.
71
8656-8662
2005
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Chen, M.; Cao, J.; Zheng, C.; Liu, Q.
Directed evolution of an artificial bifunctional enzyme, gamma-glutamyl kinase/gamma-glutamyl phosphate reductase, for improved osmotic tolerance of Escherichia coli transformants
FEMS Microbiol. Lett.
263
41-47
2006
Bacillus subtilis
Manually annotated by BRENDA team
Marchitti, S.A.; Deitrich, R.A.; Vasiliou, V.
Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase
Pharmacol. Rev.
59
125-150
2007
Homo sapiens
Manually annotated by BRENDA team
Alnouti, Y.; Klaassen, C.D.
Tissue distribution, ontogeny, and regulation of aldehyde dehydrogenase (Aldh) enzymes mRNA by prototypical microsomal enzyme inducers in mice
Toxicol. Sci.
101
51-64
2008
Mus musculus (Q9Z110)
Manually annotated by BRENDA team
Saum, S.H.; Mueller, V.
Salinity-dependent switching of osmolyte strategies in a moderately halophilic bacterium: glutamate induces proline biosynthesis in Halobacillus halophilus
J. Bacteriol.
189
6968-6975
2007
Halobacillus halophilus (A7Y114), Halobacillus halophilus
Manually annotated by BRENDA team
Hempel, J.; Kraut, A.; Wymore, T.
Gamma glutamyl semialdehyde dehydrogenase: Simulations on native and mutant forms support the importance of outer shell lysines
Chem. Biol. Interact.
178
75-78
2009
Thermus thermophilus
Manually annotated by BRENDA team
Gao, C.; Han, B.
Evolutionary and expression study of the aldehyde dehydrogenase (ALDH) gene superfamily in rice (Oryza sativa)
Gene
431
86-94
2009
Oryza sativa (Q941T1)
Manually annotated by BRENDA team
Turchetto-Zolet, A.C.; Margis-Pinheiro, M.; Margis, R.
The evolution of pyrroline-5-carboxylate synthase in plants: a key enzyme in proline synthesis
Mol. Genet. Genomics
281
87-97
2009
Pachira quinata (B1P5P3), Cedrela odorata (B1P5P4), Ceiba pentandra (B1P5P5), Ceiba pentandra (B1P5P6), Schizolobium parahyba (B1P5P7), Schizolobium parahyba (B1P5P8)
Manually annotated by BRENDA team