1.3.1.98: UDP-N-acetylmuramate dehydrogenase

This is an abbreviated version!
For detailed information about UDP-N-acetylmuramate dehydrogenase, go to the full flat file.

Reaction

Synonyms

alr5066, EC 1.1.1.158, More, MurB, MurBAb, PA2977, PaMurB, reductase, uridine diphosphoacetylpyruvoylglucosamine, type I UNAGEP reductase, UDP-GlcNAc-enoylpyruvate reductase, UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylenolpyruvyl glucosamine reductase, UDP-N-acetylenolpyruvylglucosamine reductase, UDP-N-acetylglucosamine-enoylpyruvate reductase, UDP-N-acetylmuramate dehydrogenase, UNAGEP reductase, uridine diphospho-N-acetylglucosamine-enolpyruvate reductase, uridine-5'-diphospho-N-acetyl-2-amino-2-deoxy-3-O-lactylglucose:NADP-oxidoreductase, VspiD_010100018130

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.1 With NAD⁺ or NADP⁺ as acceptor

                1.3.1.98 UDP-N-acetylmuramate dehydrogenase

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Results

in table

2

Activating Compound

42793

AA Sequence

1

Application

1

CAS Registry Number

13

Cloned(Commentary)

45

Cofactor

7

Crystallization (Commentary)

8

General Information

2

General Stability

28

IC50 Value

269

Inhibitors

24

KM Value [mM]

5

Localization

33

Metals/Ions

10

Molecular Weight [Da]

29

Natural Substrates/ Products (Substrates)

230

Organism

1

Oxidation Stability

8

Pathway

7

PDB ID

10

pH Optimum

2

pH Range

1

pH Stability

18

Protein Variants

15

Purification (Commentary)

5

Reaction

3

Reaction Type

40

Reference

5

Specific Activity [micromol/min/mg]

4

Storage Stability

42

Substrates and Products (Substrate)

10

Subunits

64

Synonyms

1

Systematic Name

3

Temperature Optimum [°C]

3

Temperature Range [°C]

2

Temperature Stability [°C]

Reaction

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Reaction on EC 1.3.1.98 - UDP-N-acetylmuramate dehydrogenase

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH + H+

5 entries

UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH + H+

ping pong mechanism, contains FAD

Streptococcus pneumoniae

-

286068

UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH + H+

reaction mechanism, detailed scheme of the second half

Staphylococcus aureus

P61431

669466

UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH + H+

the nicotinamide ring of NADP+ stacks against the si face of the isoalloxazine ring of FAD, suggesting an unusual mode of hydride transfer to flavin. Both substrates share the binding site located between two lobes of the substrate-binding domain III, consistent with a ping pong mechanism with sequential substrate binding, structural analysis of the first half-reaction, overview

Pseudomonas aeruginosa

Q9HZM7

746242

UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH + H+

ping pong mechanism, contains FAD

Streptococcus pneumoniae 100993

-

-

UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH + H+

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