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1.3.99.6: 3-oxo-5beta-steroid 4-dehydrogenase

This is an abbreviated version!
For detailed information about 3-oxo-5beta-steroid 4-dehydrogenase, go to the full flat file.

Word Map on EC 1.3.99.6

Reaction

a 3-oxo-5beta-steroid
+
acceptor
=
a 3-oxo-DELTA4-steroid
 +
reduced acceptor

Synonyms

3-keto-DELTA4-steroid-5beta-reductase, 3-oxo-5beta-steroid DELTA4-dehydrogenase, 3-oxo-DELTA4-steroid-5beta-reductase, 5beta-reductase, AKR1D1, Aldo-keto reductase family 1 member D1, Delta(4)-3-ketosteroid 5-beta-reductase, DELTA-3-ketosteroid-5beta-reductase, DELTA4-3-ketosteroid-5beta-reductase, DELTA4-3-oxosteroid 5beta-reductase, DELTA4-5beta-DH, steroid 5beta reductase, steroid 5beta-reductase, steroid DELTA-5beta-dehydrogenase, testosterone 5beta-reductase

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.99 With unknown physiological acceptors
                1.3.99.6 3-oxo-5beta-steroid 4-dehydrogenase

Substrates Products

Substrates Products on EC 1.3.99.6 - 3-oxo-5beta-steroid 4-dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
17beta-hydroxy-5beta-androstan-3-one + menaphthone
testosterone + reduced acceptor
show the reaction diagram
21-hydroxy-5beta-pregnan-3,20-dione + acceptor
21-hydroxy-pregn-4-en-3,20-dione + reduced acceptor
show the reaction diagram
-
acceptor: 1,2-naphthoquinone, 1,4-naphthoquinone, 1,4-benzoquinone, menadione or coenzyme Q10
-
-
?
3,12-dioxo-5beta-cholan-24-oic acid + menaphthone
3,12-dioxo-4-cholen-24-oic acid + reduced menaphthone
show the reaction diagram
-
-
-
-
?
3,12-dioxo-5beta-cholan-24-oic acid + phenazine methosulfate
3,12-dioxo-4-cholen-24-oic acid + reduced phenazine methosulphate
show the reaction diagram
-
-
-
-
?
3,12-dioxo-5beta-cholan-24-oic acid methyl ester + menaphthone
3,12-dioxo-4-cholen-24 oic acid methyl ester + reduced menaphthone
show the reaction diagram
-
-
-
-
?
3,12-dioxo-5beta-cholan-24-oic acid methyl ester + phenazine methosulfate
3,12-dioxo-4-cholen-24 oic acid methyl ester + reduced phenazine methosulfate
show the reaction diagram
-
-
-
-
?
3-oxo-5beta-24-cholan-oic acid + phenazine methosulfate
3-oxo-4-cholen-24-oic acid + reduced phenazine methosulfate
show the reaction diagram
-
-
-
-
?
3-oxo-5beta-cholan-24-oic acid + menaphthone
3-oxo-4-cholen-24-oic acid + reduced menaphthone
show the reaction diagram
-
-
-
-
?
4-pregnen-3,20-dione + NADH
5beta-pregnan-3,20-dione + NAD+
show the reaction diagram
5beta-androst-3,17-dione + acceptor
androst-1,4-dien-3,17-dione + reduced acceptor
show the reaction diagram
-
acceptor: 1,2-naphthoquinone, 1,4-naphthoquinone, 1,4-benzoquinone, menadione or coenzyme Q10
-
-
?
5beta-androstan-3,17-dione + acceptor
4-androsten-3,17-dione + reduced acceptor
show the reaction diagram
5beta-androstane-3,17-dione + acceptor
androst-4-en-3,17-dione + reduced acceptor
show the reaction diagram
-
acceptor: 1,2-naphthoquinone, 1,4-naphthoquinone, 1,4-benzoquinone, menadione or coenzyme Q10
-
-
?
5beta-pregnan-3,20-dione + menaphthone
4-pregnen-3,20-dione + reduced menaphthone
show the reaction diagram
-
-
-
-
?
5beta-pregnan-3,20-dione + phenazine methosulfate
4-pregnen-3,20-dione + reduced menazine methosulfate
show the reaction diagram
-
-
-
-
?
progesterone + NADPH + H+
5beta-pregnane-3,20-dione + NADP+
show the reaction diagram
-
-
-
-
?
testosterone + NADH
17beta-hydroxy-5beta-androstan-3-one + NAD+
show the reaction diagram
-
-
-
-
?
additional information
?
-