1.4.1.12: 2,4-diaminopentanoate dehydrogenase

This is an abbreviated version!
For detailed information about 2,4-diaminopentanoate dehydrogenase, go to the full flat file.

Word Map on EC 1.4.1.12

Reaction

(2R,4S)-2,4-diaminopentanoate
+
H2O
+
NAD(P)+
=
(2R)-2-amino-4-oxopentanoate
+
NH3
+
NAD(P)H
+
H+

Synonyms

2,4-DAPDH, 2,4-diaminopentanoic acid C4 dehydrogenase, 2R,4S-2,4-diaminopentanoate dehydrogenase, DAPDH

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.1 With NAD+ or NADP+ as acceptor
                1.4.1.12 2,4-diaminopentanoate dehydrogenase

Systematic Name

Systematic Name on EC 1.4.1.12 - 2,4-diaminopentanoate dehydrogenase

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SYSTEMATIC NAME
IUBMB Comments
(2R,4S)-2,4-diaminopentanoate:NAD(P)+ oxidoreductase (deaminating)
Also acts, more slowly, on 2,5-diaminohexanoate forming 2-amino-5-oxohexanoate, which then cyclizes non-enzymically to 1-pyrroline-2-methyl-5-carboxylate. It has equal activity with NAD+ and NADP+ [cf. EC 1.4.1.26, 2,4-diaminopentanoate dehydrogenase (NAD+)].