1.4.99.6: D-arginine dehydrogenase
This is an abbreviated version!
For detailed information about D-arginine dehydrogenase, go to the full flat file.
Reaction
Synonyms
D-alanine dehydrogenase, D-amino acid dehydrogenase, D-amino acid dehydrogenase DadA, DAADH, DAD, DadA, DADH, DauA, EC 1.4.99.1, NADP+-dependent D-amino acid dehydrogenase
ECTree
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Cofactor
Cofactor on EC 1.4.99.6 - D-arginine dehydrogenase
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FAD
mutant Y249F protein shows both an active yellow FAD (Y249F-y) and an inactive chemically modified green 6-hydroxy-FAD cofactor. Variants show no differences in the overall protein structure and fold. Variant Y249F-y displays an alternative conformation for some active site residues and the flavin cofactor. Y249F-y with FAD samples a metastable conformational state, not available to the wild-type enzyme. The alternate conformation in the Y249F-y enzyme is responsible for the higher spin density at the C6 atom of flavin, consistent with the formation of 6-hydroxy-FAD