1.5.1.33: pteridine reductase
This is an abbreviated version!
For detailed information about pteridine reductase, go to the full flat file.
Word Map on EC 1.5.1.33
-
1.5.1.33
-
leishmania
-
dihydrofolate
-
trypanosoma
-
antileishmanial
-
antifolate
-
promastigotes
-
leishmaniasis
-
trypanosomatids
-
pterins
-
donovani
-
amastigotes
-
trypanosomiasis
-
dhfr-t
-
trypanothione
-
reductase-thymidylate
-
tarentolae
-
dihydrobiopterin
-
glucantime
-
medicine
-
drug development
-
pharmacology
- 1.5.1.33
- leishmania
- dihydrofolate
- trypanosoma
-
antileishmanial
- antifolate
- promastigotes
- leishmaniasis
-
trypanosomatids
- pterins
- donovani
- amastigotes
- trypanosomiasis
-
dhfr-t
- trypanothione
-
reductase-thymidylate
- tarentolae
- dihydrobiopterin
-
glucantime
- medicine
- drug development
- pharmacology
Reaction
Synonyms
Atu1130, EC 1.1.1.253, H region methotrexate resistance protein, LaPTR1, LbPTR1, LdPTR1, LmPTR1, LpPTR1, More, NADPH-dependent short-chain dehydrogenase/reductase pteridine reductase, NADPH-dihydropteridine reductase, PruA, pteridine reductase, pteridine reductase 1, pteridine reductase I, PTR1, reductase, dihydropteridine (reduced nicotinamide adenine dinucleotide phosphate), Tb-PR, TbPTR1, tcptr1
ECTree
Advanced search results
Systematic Name
Systematic Name on EC 1.5.1.33 - pteridine reductase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase
The enzyme from Leishmania (both amastigote and promastigote forms) catalyses the reduction by NADPH of folate and a wide variety of unconjugated pterins, including biopterin, to their tetrahydro forms. It also catalyses the reduction of 7,8-dihydropterins and 7,8-dihydrofolate to their tetrahydro forms. In contrast to EC 1.5.1.3 (dihydrofolate reductase) and EC 1.5.1.34 (6,7-dihydropteridine reductase), pteridine reductase will not catalyse the reduction of the quinonoid form of dihydrobiopterin. The enzyme is specific for NADPH; no activity has been detected with NADH. It also differs from EC 1.5.1.3 (dihydrofolate reductase) in being specific for the Si-face of NADPH.