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EC 2.1.2.1 Details

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EC number

2.1.2.1

Accepted name

glycine hydroxymethyltransferase

Reaction

5,10-methylenetetrahydrofolate + glycine + H₂O = tetrahydrofolate + L-serine

Other name(s)

serine aldolase, threonine aldolase, serine hydroxymethylase, serine hydroxymethyltransferase, allothreonine aldolase, L-serine hydroxymethyltransferase, L-threonine aldolase, serine hydroxymethyltransferase, serine transhydroxymethylase

Systematic name

5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase

CAS registry number

9029-83-8

Comment

A pyridoxal-phosphate protein. Also catalyses the reaction of glycine with acetaldehyde to form L-threonine, and with 4-trimethylammoniobutanal to form 3-hydroxy-N⁶,N⁶,N⁶-trimethyl-L-lysine.

History

created 1961, modified 1983

EC Tree

1 Oxidoreductases

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.2 Hydroxymethyl-, formyl- and related transferases

2.1.2.1 glycine hydroxymethyltransferase

2.1.2.2 phosphoribosylglycinamide formyltransferase 1

2.1.2.3 phosphoribosylaminoimidazolecarboxamide formyltransferase

2.1.2.4 glycine formimidoyltransferase

2.1.2.5 glutamate formimidoyltransferase

2.1.2.6 created 1965, deleted 1984

2.1.2.7 D-alanine 2-hydroxymethyltransferase

2.1.2.8 deoxycytidylate 5-hydroxymethyltransferase

2.1.2.9 methionyl-tRNA formyltransferase

2.1.2.10 aminomethyltransferase

2.1.2.11 3-methyl-2-oxobutanoate hydroxymethyltransferase

2.1.2.12 created 1983, deleted 1984

2.1.2.13 UDP-4-amino-4-deoxy-L-arabinose formyltransferase

2.1.2.14 GDP-perosamine N-formyltransferase

2.1.3 Carboxy- and carbamoyltransferases

2.1.4 Amidinotransferases

2.1.5 Methylenetransferases

2.2 Transferring aldehyde or ketonic groups

2.3 Acyltransferases

2.4 Glycosyltransferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

2.6 Transferring nitrogenous groups

2.7 Transferring phosphorus-containing groups

2.8 Transferring sulfur-containing groups

2.9 Transferring selenium-containing groups

2.10 Transferring molybdenum- or tungsten-containing groups