EC Explorer

[browse EC tree] - [search]

EC 2.1.2.5 Details

show Brenda entry

EC number

2.1.2.5

Accepted name

glutamate formimidoyltransferase

Reaction

5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate

Other name(s)

FTCD (gene name), glutamate formyltransferase, formiminoglutamic acid transferase, formiminoglutamic formiminotransferase, glutamate formiminotransferase

Systematic name

5-formimidoyltetrahydrofolate:L-glutamate N-formimidoyltransferase

CAS registry number

9032-83-1

Comment

The enzyme also catalyses formyl transfer from 5-formyltetrahydrofolate to L-glutamate. In eukaryotes, it occurs as a bifunctional enzyme that also has formimidoyltetrahydrofolate cyclodeaminase (EC 4.3.1.4) activity.

History

created 1961, modified 2000 (EC 2.1.2.6 created 1965, incorporated 1984)

EC Tree

1 Oxidoreductases

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.2 Hydroxymethyl-, formyl- and related transferases

2.1.2.1 glycine hydroxymethyltransferase

2.1.2.2 phosphoribosylglycinamide formyltransferase 1

2.1.2.3 phosphoribosylaminoimidazolecarboxamide formyltransferase

2.1.2.4 glycine formimidoyltransferase

2.1.2.5 glutamate formimidoyltransferase

2.1.2.6 created 1965, deleted 1984

2.1.2.7 D-alanine 2-hydroxymethyltransferase

2.1.2.8 deoxycytidylate 5-hydroxymethyltransferase

2.1.2.9 methionyl-tRNA formyltransferase

2.1.2.10 aminomethyltransferase

2.1.2.11 3-methyl-2-oxobutanoate hydroxymethyltransferase

2.1.2.12 created 1983, deleted 1984

2.1.2.13 UDP-4-amino-4-deoxy-L-arabinose formyltransferase

2.1.2.14 GDP-perosamine N-formyltransferase

2.1.3 Carboxy- and carbamoyltransferases

2.1.4 Amidinotransferases

2.1.5 Methylenetransferases

2.2 Transferring aldehyde or ketonic groups

2.3 Acyltransferases

2.4 Glycosyltransferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

2.6 Transferring nitrogenous groups

2.7 Transferring phosphorus-containing groups

2.8 Transferring sulfur-containing groups

2.9 Transferring selenium-containing groups

2.10 Transferring molybdenum- or tungsten-containing groups