EC Explorer

[browse EC tree] - [search]

EC 3.1.21.10 Details

show Brenda entry

EC number

3.1.21.10

Accepted name

crossover junction endodeoxyribonuclease

Reaction

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction)

Other name(s)

Hje endonuclease, Holliday junction endonuclease CCE1, Holliday junction resolvase, Holliday junction-cleaving endonuclease, Holliday junction-resolving endoribonuclease, RusA Holliday junction resolvase, RusA endonuclease, RuvC endonuclease, SpCCe1 Holliday junction resolvase, crossover junction endoribonuclease, cruciform-cutting endonuclease, endo X3, endonuclease RuvC, endonuclease VII, endonuclease X3, resolving enzyme CCE1

CAS registry number

99676-43-4

Comment

The enzyme from Saccharomyces cerevisiae has no endonuclease or exonuclease activity on single-stranded or double-stranded DNA molecules that do not contain Holliday junctions.

History

created 1989 as EC 3.1.22.4, modified 2003, transferred 2021 to EC 3.1.21.10

EC Tree

1 Oxidoreductases

2 Transferases

3 Hydrolases

3.1 Acting on ester bonds

3.1.1 Carboxylic-ester hydrolases

3.1.2 Thioester hydrolases

3.1.3 Phosphoric-monoester hydrolases

3.1.4 Phosphoric-diester hydrolases

3.1.5 Triphosphoric-monoester hydrolases

3.1.6 Sulfuric-ester hydrolases

3.1.7 Diphosphoric-monoester hydrolases

3.1.8 Phosphoric-triester hydrolases

3.1.11 Exodeoxyribonucleases producing 5′-phosphomonoesters

3.1.12 Exodeoxyribonucleases producing 3′-phosphomonoesters

3.1.13 Exoribonucleases producing 5′-phosphomonoesters

3.1.14 Exoribonucleases producing 3'-phosphomonoesters

3.1.15 Exonucleases that are active with either ribo- or deoxyribonucleic acids and produce 5'-phosphomonoesters

3.1.16 Exonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3'-phosphomonoesters

3.1.21 Endodeoxyribonucleases producing 5'-phosphomonoesters

3.1.21.1 deoxyribonuclease I

3.1.21.2 deoxyribonuclease IV

3.1.21.3 type I site-specific deoxyribonuclease

3.1.21.4 type II site-specific deoxyribonuclease

3.1.21.5 type III site-specific deoxyribonuclease

3.1.21.6 CC-preferring endodeoxyribonuclease

3.1.21.7 deoxyribonuclease V

3.1.21.8 T₄ deoxyribonuclease II

3.1.21.9 T₄ deoxyribonuclease IV

3.1.21.10 crossover junction endodeoxyribonuclease

3.1.22 Endodeoxyribonucleases producing 3'-phosphomonoesters

3.1.23 Site-specific endodeoxyribonucleases: cleavage is sequence specific (deleted sub-subclass)

3.1.24 Site specific endodeoxyribonucleases: cleavage is not sequence specific (deleted sub-subclass)

3.1.24.1 created 1978, modified 1982, deleted 1984

3.1.24.2 created 1978, modified 1982, deleted 1984

3.1.24.3 created 1978, modified 1982, deleted 1984

3.1.24.4 created 1978, modified 1982, deleted 1984

3.1.25 Site-specific endodeoxyribonucleases that are specific for altered bases

3.1.26 Endoribonucleases producing 5'-phosphomonoesters

3.1.27 Endoribonucleases producing 3'-phosphomonoesters

3.1.30 Endoribonucleases that are active with either ribo- or deoxyribonucleic acids and produce 5'-phosphomonoesters

3.1.31 Endoribonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3'-phosphomonoesters

3.2 Glycosylases

3.3 Acting on ether bonds

3.4 Acting on peptide bonds (peptidases)

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.6 Acting on acid anhydrides

3.7 Acting on carbon-carbon bonds

3.8 Acting on halide bonds

3.9 Acting on phosphorus-nitrogen bonds

3.10 Acting on sulfur-nitrogen bonds

3.11 Acting on carbon-phosphorus bonds

3.12 Acting on sulfur-sulfur bonds

3.13 Acting on carbon-sulfur bonds