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EC 5.3.3.8 Details
show Brenda entryEC number
5.3.3.8
Accepted name
Δ3-Δ2-enoyl-CoA isomerase
Reaction
(1) a (3Z)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA;;(2) a (3E)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA
Other name(s)
ECI (gene name),
dodecenoyl-CoA isomerase,
dodecenoyl-CoA Δ-isomerase,
Δ3-cis-Δ2-trans-enoyl-CoA isomerase,
acetylene-allene isomerase,
dodecenoyl-CoA Δ3-cis-Δ2-trans-isomerase,
dodecenoyl-CoA (3Z)-(2E)-isomerase
Systematic name
(3Z/3E)-alk-3-enoyl-CoA (2E)-isomerase
CAS registry number
62213-29-0
Comment
The enzyme participates in the β-oxidation of fatty acids with double bonds at an odd position. Processing of these substrates via the β-oxidation system results in intermediates with a cis- or trans-double bond at position C3, which cannot be processed further by the regular enzymes of the β-oxidation system. This enzyme isomerizes the bond to a trans bond at position C2, which can be processed further. The reaction rate is ten times higher for the (3Z) isomers than for (3E) isomers. The enzyme can also catalyse the isomerization of 3-acetylenic fatty acyl thioesters to 2,3-dienoyl fatty acyl thioesters.
History
created 1978, modified 1980, modified 2018
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1 Oxidoreductases
3 Hydrolases
5.3.3.1 steroid Δ-isomerase
