EC Explorer

[browse EC tree] - [search]

EC 5.3.3.14 Details

show Brenda entry

EC number

5.3.3.14

Accepted name

trans-2-decenoyl-[acyl-carrier protein] isomerase

Reaction

a trans-dec-2-enoyl-[acyl-carrier protein] = a cis-dec-3-enoyl-[acyl-carrier protein]

Other name(s)

β-hydroxydecanoyl thioester dehydrase, trans-2-cis-3-decenoyl-ACP isomerase, trans-2,cis-3-decenoyl-ACP isomerase, trans-2-decenoyl-ACP isomerase, FabM, decenoyl-[acyl-carrier-protein] Δ²-trans-Δ³-cis-isomerase

Systematic name

decenoyl-[acyl-carrier protein] Δ²-trans-Δ³-cis-isomerase

CAS registry number

9030-80-2

Comment

While the enzyme from Escherichia coli is highly specific for the 10-carbon enoyl-ACP, the enzyme from Streptococcus pneumoniae can also use the 12-carbon enoyl-ACP as substrate in vitro but not 14- or 16-carbon enoyl-ACPs [3]. ACP can be replaced by either CoA or N-acetylcysteamine thioesters. The cis-3-enoyl product is required to form unsaturated fatty acids, such as palmitoleic acid and cis-vaccenic acid, in dissociated (or type II) fatty-acid biosynthesis.

History

created 2006

EC Tree

1 Oxidoreductases

2 Transferases

3 Hydrolases

3.1 Acting on ester bonds

3.2 Glycosylases

3.3 Acting on ether bonds

3.4 Acting on peptide bonds (peptidases)

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.6 Acting on acid anhydrides

3.7 Acting on carbon-carbon bonds

3.8 Acting on halide bonds

3.9 Acting on phosphorus-nitrogen bonds

3.10 Acting on sulfur-nitrogen bonds

3.11 Acting on carbon-phosphorus bonds

3.12 Acting on sulfur-sulfur bonds

3.13 Acting on carbon-sulfur bonds

4 Lyases

5 Isomerases

5.1 Racemases and epimerases

5.2 cis-trans-Isomerases

5.3 Intramolecular oxidoreductases

5.3.1 Interconverting aldoses and ketoses, and related compounds

5.3.2 Interconverting keto- and enol-groups

5.3.3 Transposing C=C bonds

5.3.3.1 steroid Δ-isomerase

5.3.3.2 isopentenyl-diphosphate Δ-isomerase

5.3.3.3 vinylacetyl-CoA Δ-isomerase

5.3.3.4 muconolactone Δ-isomerase

5.3.3.5 cholestenol Δ-isomerase

5.3.3.6 methylitaconate Δ-isomerase

5.3.3.7 aconitate Δ-isomerase

5.3.3.8 Δ³-Δ²-enoyl-CoA isomerase

5.3.3.9 prostaglandin-A₁ Δ-isomerase

5.3.3.10 5-carboxymethyl-2-hydroxymuconate Δ-isomerase

5.3.3.11 isopiperitenone Δ-isomerase

5.3.3.12 L-dopachrome isomerase

5.3.3.13 polyenoic fatty acid isomerase

5.3.3.14 trans-2-decenoyl-[acyl-carrier protein] isomerase

5.3.3.15 ascopyrone tautomerase

5.3.3.16 4-oxalomesaconate tautomerase

5.3.3.17 trans-2,3-dihydro-3-hydroxyanthranilate isomerase

5.3.3.18 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase

5.3.3.19 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate isomerase

5.3.3.20 2-hydroxyisobutanoyl-CoA mutase

5.3.3.21 Δ^3,5-Δ^2,4-dienoyl-CoA isomerase

5.3.3.22 lutein isomerase

5.3.3.23 S-methyl-5-thioribulose 1-phosphate isomerase

5.3.4 Transposing S-S bonds

5.3.99 Other intramolecular oxidoreductases

5.4 Intramolecular transferases

5.5 Intramolecular lyases

5.6 Isomerases altering macromolecular conformation

5.99 Other isomerases

6 Ligases

7 Translocases