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Information on EC 1.14.14.141 - psoralen synthase

for references in articles please use BRENDA:EC1.14.14.141

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IUBMB Comments

This microsomal cytochrome P-450 (heme-thiolate) enzyme is rather specific for (+)-marmesin, although it can also accept 5-hydroxymarmesin to a much lesser extent. Furanocoumarins protect plants from fungal invasion and herbivore attack. (+)-Columbianetin, the angular furanocoumarin analogue of the linear furanocoumarin (+)-marmesin, acts as a competitive inhibitor even though it is not a substrate.

The enzyme appears in viruses and cellular organisms

Synonyms
psoralen synthase, cyp71aj3, cyp71aj1, cyp71aj2, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(+)-marmesin + [reduced NADPH-hemoprotein reductase] + O2 = psoralen + [oxidized NADPH-hemoprotein reductase] + acetone + 2 H2O
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
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Highest Expressing Human Cell Lines
Cell Line Links Gene Links