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Information on EC 1.14.14.81 - flavanoid 3',5'-hydroxylase

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IUBMB Comments
A heme-thiolate protein (P-450). The 3',5'-dihydroxyflavanone is formed via the 3'-hydroxyflavanone. In Petunia hybrida the enzyme acts on naringenin, eriodictyol, dihydroquercetin (taxifolin) and dihydrokaempferol (aromadendrin). The enzyme catalyses the hydroxylation of 5,7,4'-trihydroxyflavanone (naringenin) at either the 3' position to form eriodictyol or at both the 3' and 5' positions to form 5,7,3',4',5'-pentahydroxyflavanone (dihydrotricetin). The enzyme also catalyses the hydroxylation of 3,5,7,3',4'-pentahydroxyflavanone (taxifolin) at the 5' position, forming ampelopsin. NADH is not a good substitute for NADPH.
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The enzyme appears in viruses and cellular organisms
Synonyms
f3'5'h, flavonoid 3',5'-hydroxylase, flavonoid 3'5'-hydroxylase, cyp75a, cyp75a31, flavonoid 3'5' hydroxylase, f3',5'h, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a 3'-hydroxyflavanone + [reduced NADPH-hemoprotein reductase] + O2 = a 3',5'-dihydroxyflavanone + [oxidized NADPH-hemoprotein reductase] + H2O
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(1b)
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a flavanone + 2 [reduced NADPH-hemoprotein reductase] + 2 O2 = a 3',5'-dihydroxyflavanone + 2 [oxidized NADPH-hemoprotein reductase] + 2 H2O
show the reaction diagram
overall reaction
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a flavanone + [reduced NADPH-hemoprotein reductase] + O2 = a 3'-hydroxyflavanone + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
(1a)
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