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BRENDA support

Information on EC 1.2.5.1 - pyruvate dehydrogenase (quinone)

for references in articles please use BRENDA:EC1.2.5.1

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IUBMB Comments

Flavoprotein (FAD) . This bacterial enzyme is located on the inner surface of the cytoplasmic membrane and coupled to the respiratory chain via ubiquinone [2,3]. Does not accept menaquinone. Activity is greatly enhanced by lipids [4,5,6]. Requires thiamine diphosphate . The enzyme can also form acetoin .

The expected taxonomic range for this enzyme is: Bacteria, Archaea

Synonyms
pyruvate:quinone oxidoreductase, poxec, pyruvate oxidase b, ubiquinone-dependent pyruvate oxidase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
pyruvate + ubiquinone + H2O = acetate + CO2 + ubiquinol
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
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-, -
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