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EC 1.8.4.5
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formerly, part transferred
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free-methionine-R-sulfoxide reductase
methionine sulfoxide reductase
free-methionine-R-sulfoxide reductase

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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
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free-methionine-R-sulfoxide reductase
Yarrowia lipolytica YlCW001 v1.0
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fRMsr

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fRMsr
Yarrowia lipolytica YlCW001 v1.0
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methionine sulfoxide reductase

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methionine sulfoxide reductase
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L-(-)-methionine S-oxide + NADPH
L-methionine + NADP+ + H2O
L-methionine (S)-S-oxide + NADPH
L-methionine + NADP+ + H2O
L-methionine (S)-S-oxide + reduced DTT
L-methionine + oxidized DTT + H2O
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highest activity at 10 mM
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L-methionine (S)-sulfoxide + NADPH + H+
L-methionine + NADP+ + H2O
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membrane-bound enzyme form Mem-R,S-Msr
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L-methionine sulfoxide enkephalin + NADPH
L-methionine enkephalin + NADP+ + H2O
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membrane-bound enzyme form Mem-R,S-Msr
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L-methionine-(S)-S-oxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
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N-acetyl-L-methionine (S)-sulfoxide + thioredoxin
N-acetyl-L-methionine + thioredoxin disulfide + H2O
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membrane-bound enzyme form Mem-R,S-Msr
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sulindac + NADPH
sulindac sulfide + NADP+ + H2O
additional information
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L-(-)-methionine S-oxide + NADPH

L-methionine + NADP+ + H2O
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the enzyme is specific for the L-(-)-stereoisomer
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ir
L-(-)-methionine S-oxide + NADPH
L-methionine + NADP+ + H2O
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the enzyme is absolutely specific for the L-(-)-stereoisomer
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L-methionine (S)-S-oxide + NADPH

L-methionine + NADP+ + H2O
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L-methionine (S)-S-oxide + NADPH
L-methionine + NADP+ + H2O
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substrate is L-Met-DL-sulfoxide or L-Met-L-sulfoxide
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L-methionine (S)-S-oxide + NADPH
L-methionine + NADP+ + H2O
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substrate is L-Met-DL-sulfoxide or L-Met-L-sulfoxide
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sulindac + NADPH

sulindac sulfide + NADP+ + H2O
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activation of a methionine sulfoxide-containing prodrug, activity with membrane-bound enzyme form Mem-R,S-Msr
activated drug which inhibits cyclooxygenase 1 and 2 and exhibits anti-inflammatory activity
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sulindac + NADPH
sulindac sulfide + NADP+ + H2O
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activity with membrane-bound enzyme form Mem-R,S-Msr
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additional information

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the enzyme protects cells against oxidative damage and plays a role in age-related misfunctions
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additional information
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substrate specificity, overview, Mem-R,S-Msr can also catalyze the reduction of L-methionine (R)-sulfoxide, EC 1.8.4.14, enzyme reduces oxidized methionine residues of the ribosomal protein L12, which becomes reversibly inactivated and forms monomers instead of dimers upon oxidation
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additional information
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no activity with peptide-L-methionine-(S)-S-oxide
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additional information
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methionine sulfoxide reduction pathway, overview
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additional information
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the enzyme might act in vivo on the free methionine sulfoxide substrate or on protein-bound methionine sulfoxide residues
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additional information
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the enzyme might act in vivo on the free methionine sulfoxide substrate or on protein-bound methionine sulfoxide residues
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additional information
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possible pathway, overview
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additional information
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the purified enzyme may contain thioredoxin
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additional information

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a survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
additional information
a survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites were devoid of msr genes
additional information
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survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
additional information
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survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
additional information
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survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
additional information
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survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
additional information
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survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
additional information
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survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
additional information
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survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
additional information
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survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
additional information
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survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
additional information
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survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
additional information
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survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
additional information
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survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
additional information
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survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
additional information
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survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
additional information
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survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
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additional information
Yarrowia lipolytica YlCW001 v1.0
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survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
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additional information
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survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
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additional information
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survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
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additional information
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survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
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additional information
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survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
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additional information
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survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
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additional information
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survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
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additional information
-
survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
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additional information
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survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
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additional information
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survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
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additional information
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a survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites were devoid of msr genes
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additional information
-
survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
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additional information
-
survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
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additional information
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a survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
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additional information
-
survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
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additional information
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survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
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additional information
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survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
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additional information
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survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
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additional information
-
survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
-
additional information
-
survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
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additional information
-
survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
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additional information
-
survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
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additional information
-
survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
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additional information
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survey of msr genes in almost 700 genomes across the fungal kingdom. Most fungi possess one gene coding for each type of methionine sulfoxide reductase: MsrA, MsrB, and fRMsr. Several fungi living in anaerobic environments or as obligate intracellular parasites are devoid of msr genes
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Ejiri, S.; Weissbach, H.; Brot, N.
The purification of methionine sulfoxide reductase from Escherichia coli
Anal. Biochem.
102
393-398
1980
Escherichia coli, Escherichia coli B
brenda
Black, S.; Harte, E.M.; Hudson, B.; Wartolofsky, L.
A specific enzymatic reduction of L(-)methionine sulfoxide and a related nonspecific reduction of disulfides
J. Biol. Chem.
235
2910-2916
1960
Saccharomyces cerevisiae
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brenda
Ejiri, S.; Weissbach, H.; Brot, N.
Reduction of methionine sulfoxide to methionine by Escherichia coli
J. Bacteriol.
139
161-164
1979
Escherichia coli K-12, Escherichia coli K-12 2276
brenda
Weissbach, H.; Resnick, L.; Brot, N.
Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage
Biochim. Biophys. Acta
1703
203-212
2005
Escherichia coli
brenda
Hage, H.; Rosso, M.N.; Tarrago, L.
Distribution of methionine sulfoxide reductases in fungi and conservation of the free-methionine-R-sulfoxide reductase in multicellular eukaryotes
Free Radic. Biol. Med.
169
187-215
2021
Pichia kudriavzevii, Yarrowia lipolytica, Hortaea werneckii, Rhizopus microsporus, Rhizopus microsporus var. chinensis, Crucibulum laeve, Dendrothele bispora, Tulasnella calospora, Ramaria rubella, Coprinellus micaceus, Absidia repens, Smittium mucronatum, Smittium culicis, Gonapodya prolifera, Coniochaeta sp., Saccharomyces cerevisiae (P36088), Smittium mucronatum ALG-7-W6, Yarrowia lipolytica YlCW001 v1.0, Rhizopus microsporus var. chinensis CCTCC M201021, Smittium culicis GSMNP, Rhizopus microsporus ATCC 11559, Yarrowia lipolytica CLIB122, Yarrowia lipolytica YB392 v1.0, Yarrowia lipolytica YB419 v1.0, Ramaria rubella UT-36052-T v1.0, Dendrothele bispora CBS 962.96 v1.0, Saccharomyces cerevisiae ATCC 204508 (P36088), Yarrowia lipolytica CLIB 89 (W29), Gonapodya prolifera v1.0, Crucibulum laeve CBS 166.37 v1.0, Yarrowia lipolytica YB566 v1.0, Pichia kudriavzevii CBS573, Yarrowia lipolytica YB567 v1.0, Yarrowia lipolytica YB420 v1.0, Coprinellus micaceus FP101781 v2.0, Yarrowia lipolytica FKP355 v1.0, Absidia repens NRRL 1336, Hortaea werneckii EXF-2000 M0 v1.0, Tulasnella calospora AL13/4D v1.0
brenda