EC Number   |
Natural Substrates |
|---|
    1.1.1.42 | isocitrate + NADP+ |
isozymes are compartment interchangeable for glutamate synthesis, although mitochondrial localization has a positive impact on this function during fermentative growth |
| 1.1.1.42 | isocitrate + NADP+ |
key enzyme of the tricarboxylic acid cycle |
| 1.1.1.42 | isocitrate + NADP+ |
metabolic regulation of the isozymes |
| 1.1.1.42 | isocitrate + NADP+ |
metabolic regulation, involved in the tricarboxylic acid cycle |
| 1.1.1.42 | isocitrate + NADP+ |
the cytosolic isozyme supplies 2-oxoglutarate for the photorespiratory ammonia fixation, pyridine nucleotide contents in mitochondria and cytosol, regulation, overview |
| 1.1.1.42 | isocitrate + NADP+ |
overall reaction |
| 1.1.1.42 | isocitrate + NADP+ |
isocitrate dehydrogenase is an important NADPH-generating enzyme in the endoplasmic reticulum |
| 1.1.1.42 | isocitrate + NADP+ |
the enzyme could have a protective antioxidant role against certain environmental stresses in plants |
| 1.1.1.42 | isocitrate + NADP+ |
strict substrate and coenzyme specificity |
| 1.1.1.42 | more |
86% of total activity in the cell, main factor for synthesis of 2-oxoglutarate. Enzyme and cytoplasmic aspartate aminotransferase are regulated oppositely and the catalytic activity of one enzyme can be stimulated concurrently with a decrease in the activity of the other |
