EC Number   |
Natural Substrates |
|---|
    1.1.1.42 | more |
during oxidative stress, enzyme activity appears to be modulated through enzymatic glutathionylation and deglutathionylation |
| 1.1.1.42 | more |
enzyme plays an important regulatory role in cellular defense against oxidative stress and in senescence |
| 1.1.1.42 | more |
suppression of enzyme activity by small interfering RNA results in impairment of glucose-stimulated insulin secretion, attenuates glucose-induced increments in pyruvate cycling activity and in NADPH levels, and causes increases in lactate production |
| 1.1.1.42 | more |
NADP+-dependent isocitrate dehydrogenase may play an important role in regulating the apoptosis induced by heat shock |
| 1.1.1.42 | more |
NADP+-dependent isocitrate dehydrogenase may play an important role in regulating the apoptosis induced by TNF-alpha and anticancer drugs |
| 1.1.1.42 | more |
NADP+-dependent isocitrate dehydrogenase plays an important protective role in apoptosis of HL-60 cells induced by singlet oxygen |
| 1.1.1.42 | more |
IDPm expression in HepG2 cells regulates ethanol-induced toxicity |
| 1.1.1.42 | more |
the R132H mutant IDH1 directly converts 2-oxoglutarate to 2-hydroxyglutarate, that rapidly accumulates in the medium of cells expressing R132H mutant IDH1 |
| 1.1.1.42 | oxalosuccinate |
- |
