EC Number   |
Protein Variants |
Reference |
|---|
   1.14.11.51 | H287A |
no residual m6A demethylase activity, about 25% decrease in apurinic/apyrimidinic lyase activity |
764135 |
| 1.14.11.51 | H287A |
residue plays an important role in substrate recognition and catalysis |
764114 |
| 1.14.11.51 | K133A |
about 50% decrease in m6A demethylase activity, about 45% decrease in apurinic/apyrimidinic lyase activity |
764135 |
| 1.14.11.51 | K158A |
mutation of basic residue of Flip1 region, abolishes N6-mA demethylation activity of ALKBH1 |
764442 |
| 1.14.11.51 | R159A |
mutation of basic residue of Flip1 region, abolishes N6-mA demethylation activity of ALKBH1 |
764442 |
| 1.14.11.51 | R160A |
mutation of basic residue of Flip1 region, abolishes N6-mA demethylation activity of ALKBH1 |
764442 |
| 1.14.11.51 | R167A |
mutation of basic residue of Flip1 region, abolishes N6-mA demethylation activity of ALKBH1 |
764442 |
| 1.14.11.51 | R169A |
mutation of basic residue of Flip1 region, abolishes N6-mA demethylation activity of ALKBH1 |
764442 |
| 1.14.11.51 | R338A |
residue plays an important role in substrate recognition and catalysis |
764114 |
| 1.14.11.51 | R344A |
mutation in highly conserved residue, strong decrease in demethylation ability |
764114 |
