1.14.13.7: phenol 2-monooxygenase (NADPH)
This is an abbreviated version!
For detailed information about phenol 2-monooxygenase (NADPH), go to the full flat file.
Word Map on EC 1.14.13.7
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1.14.13.7
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catechols
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phenol-degrading
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hydroxylases
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2,3-dioxygenase
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trichosporon
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cutaneum
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meta-cleavage
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diiron
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cresol
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comamonas
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2-hydroxymuconic
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testosteroni
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haldane
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coke
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radioresistens
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carboxylate-bridged
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meta-pathway
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ortho-cleavage
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methylococcus
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cis,cis-muconate
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coking
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environmental protection
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industry
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synthesis
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degradation
- 1.14.13.7
- catechols
-
phenol-degrading
- hydroxylases
-
2,3-dioxygenase
- trichosporon
- cutaneum
-
meta-cleavage
-
diiron
- cresol
- comamonas
-
2-hydroxymuconic
- testosteroni
-
haldane
-
coke
- radioresistens
-
carboxylate-bridged
-
meta-pathway
-
ortho-cleavage
-
methylococcus
- cis,cis-muconate
-
coking
- environmental protection
- industry
- synthesis
- degradation
Reaction
Synonyms
DmpLNO, flavin containing monooxygenase, LmPH, Mph, MphN, multi-component phenol hydroxylase, multicomponent PH, multicomponent phenol hydroxylase, multicomponent phenol hydroxylase alpha subunit, NCgl2588, oxygenase, phenol 2-mono-, PHE, phenol hydroxylase, phenol o-hydroxylase, PHH, phhY, PHIND, PHO, PHR, single-component PH, SPH
ECTree
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Inhibitors
Inhibitors on EC 1.14.13.7 - phenol 2-monooxygenase (NADPH)
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accessory component PHK of phenol hydroxylase
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the accessory component of the phenol hydroxylase mediates inhibition of phenol hydroxylase activity, overview
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dithiothreitol
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dithiothreitol acts as H2O2 generator and inhibits the oxygenase component of the enzyme, catalase protects the loss of activity
ethynylbenzene
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reversible, competitive inhibition at concentrations above 1 mM
p-chloromercuribenzoate
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inhibition is reversed by dithiothreitol
pyridoxal 5'-phosphate
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reversible, 50% loss of activity in 2 min at 0.5 mM
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benzoate causes transcriptional repression of phenol utilization by transcriptional inhibition of the mph operon. MphR encoding the transcriptional activator and mphN encoding the largest subunit of multi-component phenol hydroxylase in the benA mutant are significantly downregulated (about 7- and 70fold) on the basis of mRNA levels when benzoate is added to the medium
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additional information
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strain IS-67 could not grow in medium supplemented with 1000 mg/l of phenol
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additional information
strain IS-67 could not grow in medium supplemented with 1000 mg/l of phenol
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additional information
strain IS-67 could not grow in medium supplemented with 1000 mg/l of phenol
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additional information
strain IS-67 could not grow in medium supplemented with 1000 mg/l of phenol
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additional information
strain IS-67 could not grow in medium supplemented with 1000 mg/l of phenol
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additional information
strain IS-67 could not grow in medium supplemented with 1000 mg/l of phenol
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additional information
strain IS-67 could not grow in medium supplemented with 1000 mg/l of phenol
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additional information
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Fe2+ chelators (phenanthroline and sodium arsenate), heavy metals, denaturants and oxidizing agents show inhibitory effect on phenol hydroxylation activity of the enzyme. Sodium diethyldithiocarbamte (Cu chelator) has no inhibitory effect on phenol hydroxylation activity
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