2.1.1.6: catechol O-methyltransferase
This is an abbreviated version!
For detailed information about catechol O-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.6
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2.1.1.6
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dopamine
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val158met
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catechols
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parkinson
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monoamine
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dopaminergic
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schizophrenia
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prefrontal
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levodopa
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estrogen
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val
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o-methylation
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psychiatric
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norepinephrine
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entacapone
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l-dopa
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tolcapone
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serotonin
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noradrenaline
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dyskinesia
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neurotransmitter
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striatal
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psycho
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dopac
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carbidopa
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verbal
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3,4-dihydroxyphenylacetic
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extraneuronal
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5-httlpr
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low-activity
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parkinsonian
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homovanillic
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normetanephrine
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benserazide
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antiparkinsonian
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synthesis
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endophenotype
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dsm-iv
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3h-noradrenaline
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2-methoxyestradiol
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analysis
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tropolone
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updrs
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slc6a4
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dihydroxyphenylacetic
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amantadine
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pargyline
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oxidase-b
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phenylethanolamine-n-methyltransferase
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metanephrine
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selegiline
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medicine
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antisocial
- 2.1.1.6
- dopamine
-
val158met
- catechols
- parkinson
-
monoamine
-
dopaminergic
-
schizophrenia
-
prefrontal
- levodopa
- estrogen
- val
-
o-methylation
-
psychiatric
- norepinephrine
- entacapone
- l-dopa
- tolcapone
- serotonin
- noradrenaline
- dyskinesia
-
neurotransmitter
- striatal
-
psycho
-
dopac
- carbidopa
-
verbal
-
3,4-dihydroxyphenylacetic
-
extraneuronal
-
5-httlpr
-
low-activity
-
parkinsonian
-
homovanillic
- normetanephrine
- benserazide
-
antiparkinsonian
- synthesis
-
endophenotype
-
dsm-iv
-
3h-noradrenaline
- 2-methoxyestradiol
- analysis
- tropolone
-
updrs
-
slc6a4
-
dihydroxyphenylacetic
- amantadine
- pargyline
-
oxidase-b
-
phenylethanolamine-n-methyltransferase
- metanephrine
- selegiline
- medicine
-
antisocial
Reaction
Synonyms
catechol methyltransferase, catechol-O-methyl transferase, catechol-O-methyl transferase, membrane bound, catechol-O-methyl transferase, soluble, catechol-O-methyltransferase, catechol-O-transferase, catecholamine O-methyltransferase, COMT, COMT I, COMT II, COMT-mb, COMT-s, COMT1, COMT2, CTOMT1, L-COMT, MB-COMT, methyltransferase, catechol, S-COMT, SCOMT
ECTree
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Purification
Purification on EC 2.1.1.6 - catechol O-methyltransferase
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GST 4B Sepharose resin column chromatography, Super Q-5PW column chromatography, and Superdex 75 gel filtration
GST Sepharose resin column chromatography, GSTrap column chromatography, Super Q-5PW column chromatography, and Superdex 75 gel filtration
overview on purification of native and recombinant protein
purification of recombinant human soluble COMT using hydrophobic interaction chromatography, as the main isolation method, from an Escherichia coli culture broth
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recombinant membrane-bound isoform, by arginine-affinity chromatography. Optimized conditions for isolation and purification consist in loading of 4 mg of total protein onto the column previously equilibrated at 20 °C and recovery of enzyme in a purified fraction using 500 mM NaCl, 10 mM DTT and 0.5% (v/v) Triton X-100 in 10 mM Tris buffer (pH 7) with a total bioactivity recovery of 24% and 4.95fold purification
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recombinant protein, by arginine-affinity chromatography. Loading of 4 mg of total protein lysate leads to recovery of a purified fraction with a total bioactivity recovery of 24% and a purification fold of 4.95
TALON metal affinity resin column chromatography, Superdex 75 gel filtration