2.2.1.1: transketolase
This is an abbreviated version!
For detailed information about transketolase, go to the full flat file.
Word Map on EC 2.2.1.1
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2.2.1.1
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thiamin
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pentose
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erythrocyte
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pyrophosphate
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transaldolase
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glucose-6-phosphate
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tpp
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ribose
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5-phosphate
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aldolase
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non-oxidative
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glycation
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encephalopathy
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pyridoxine
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apoenzyme
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phosphoglycerate
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wernicke
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baker
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oxythiamine
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neuropathy
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ribose-5-phosphate
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thiamine-deficient
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xylulose
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thiamine-dependent
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6-phosphogluconate
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riboflavin
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calvin
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pharmacology
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drug development
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biotechnology
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pentose-phosphate
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xylulokinase
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industry
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alpha-ketoglutarate
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dihydroxyacetone
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warburg
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phosphoketolase
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3-epimerase
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hemolysates
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pyrophosphokinase
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xylitol
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phosphoribulokinase
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thiaminase
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hydroxypyruvate
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aminopyrimidine
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fructose-6-phosphate
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medicine
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fructose-1,6-bisphosphate
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antivitaminous
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erythrose
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egypt
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thdp-dependent
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diphosphate-dependent
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synthesis
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isotopomer
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analysis
- 2.2.1.1
- thiamin
- pentose
- erythrocyte
- pyrophosphate
- transaldolase
- glucose-6-phosphate
- tpp
- ribose
- 5-phosphate
- aldolase
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non-oxidative
-
glycation
- encephalopathy
- pyridoxine
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apoenzyme
- phosphoglycerate
- wernicke
-
baker
- oxythiamine
- neuropathy
- ribose-5-phosphate
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thiamine-deficient
- xylulose
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thiamine-dependent
- 6-phosphogluconate
- riboflavin
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calvin
- pharmacology
- drug development
- biotechnology
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pentose-phosphate
- xylulokinase
- industry
- alpha-ketoglutarate
- dihydroxyacetone
-
warburg
- phosphoketolase
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3-epimerase
- hemolysates
-
pyrophosphokinase
- xylitol
- phosphoribulokinase
- thiaminase
- hydroxypyruvate
- aminopyrimidine
- fructose-6-phosphate
- medicine
- fructose-1,6-bisphosphate
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antivitaminous
- erythrose
-
egypt
-
thdp-dependent
-
diphosphate-dependent
- synthesis
-
isotopomer
- analysis
Reaction
Synonyms
glycolaldehydetransferase, STM14_2885, STM14_2886, TK16, TKA, TKL, TKL1, Tkl2, TKT, TKT10, TKT3, TKT7, TktA, TktB, TKTc, TKTL-1, TKTL1, TKTL2, TKTp, transketolase, transketolase 10, transketolase 3, transketolase 7, transketolase A, transketolase B, transketolase like 1, transketolase-1, transketolase-like 1, transketolase-like enzyme 1, transketolase-like-1, transketolase-like-1-gene, transketolase-like-2
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General Information
General Information on EC 2.2.1.1 - transketolase
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malfunction
metabolism
physiological function
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enzyme knockdown suppresses HCC cell proliferation by inducing reactive eoxygen species accumulation and reactive oxygen species-associated cell-cycle delay
malfunction
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enzyme silencing aggravates the effect of chilling on growth in cucumber seedlings. Cucumber seedlings with enzyme inhibition decrease the mRNA level of FBPase
malfunction
A0A0F6B484; A0A0F6B483, A0A0F6B4M5, A0A0F6B6H7
transketolase-deficient Salmonella enterica Typhimurium can grow with glucose, but not ribose, as the sole carbon source
malfunction
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transketolase-deficient Salmonella enterica Typhimurium can grow with glucose, but not ribose, as the sole carbon source
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transketolase is a key enzyme of the pentose phosphate pathway, the Calvin cycle and the ribulose monophosphate cycle
metabolism
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the enzyme is fundamental in the non-oxidative branch of the pentose phosphate pathway
metabolism
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transketolase is a key enzyme of the pentose phosphate pathway, the Calvin cycle and the ribulose monophosphate cycle
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after anti-transketolase-like enzyme 1 siRNA treatment in HeLa cells, total transketolase activity is significantly reduced and cell proliferation is remarkably inhibited. In endocervical epithelia cells, total transketolase activity and cell proliferation have no significant differences after siRNA treatment
physiological function
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transketolase silencing inhibits the proliferation, growth, and migratory abilities of cultured hippocampal progenitor cells, without affecting neuritogenesis of culture hippocampal neurons
physiological function
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evaluation of the loss-of-function results of transketolase by microinjection of transketolase double-stranded RNAs into germinal vesicle -stage oocytes, and culture of the oocytes in vitro. Despite the complete and specific knockdown of transketolase expression, germinal vesical breakdown occurred and meiosis was arrested at the metaphase I stage. The arrested oocytes exhibit spindle loss, chromosomal aggregation, and declined maturation promoting factor and mitogen-activated protein kinase activities. Transketolase and its associated pentose phosphate pathway play an important role in the MI-MII transition of the oocytes' meiotic cell cycle, but not in the process of germinal vesical breakdown
physiological function
gene disruption mutant displays a significant decrease in both growth on xylose and xylose-fermenting ability, and enzmye is also required for utilization of glucose. The rate of xylose consumption and ethanol production is slightly impaired in overexpressing strains
physiological function
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gene knock out from procyclic Trypanosoma brucei results in loss of transketolase activity ,but no growth phenotype is evident in the null mutants. Metabolite profiling to compare wild type and TKT null mutants reveals substantial increases in transketolase substrate metabolites coupled to loss of sedoheptulose 7-phosphate
physiological function
growth on xylose and xylose-fermenting ability are slightly influenced in a gene deltion mutant when xylose is used as the sole carbon source. The rate of xylose consumption and ethanol production is slightly impaired in overexpressing strains
physiological function
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in a transketolase I overexpressing strain, protein folding, transcriptional regulation, amino acid transport and Calvin-Benson-Bassham cycle-associated carbon metabolism are increased. In a transketolase I overexpressing strain, ATP synthesis, carbohydrate transport, glycolysis-associated carbon metabolism and Calvin-Benson-Bassham cycle-associated carbon metabolism are increased. Phosphoenolpyruvate carboxykinase activity is higher in transketolase over-expressing strains than in the control strain
physiological function
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Overexpression or deletion of the enzyme gene interferes with MarR repression of the marRAB operon. Deletion of enzyme gene increases antibiotic and oxidative stress susceptibilities, while its overexpression decreases them
physiological function
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increased transketolase activity causes reduced growth and results in leaf chlorosis
physiological function
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the enzyme is required for cancer growth because of its ability to affect the production of NAPDH to counteract oxidative stress. Overexpression of the enzyme is also closely associated with aggressive clinicopathological hepatocellular carcinoma cell features, including the presence of venous invasion and tumor microsatellite formation, increased tumor size, and absence of tumor encapsulation
physiological function
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enzyme overexpression relieves the effect of chilling on growth in cucumber seedlings. Cucumber seedlings, which overexpress enzyme, promote the mRNA level of FBPase
physiological function
isoform TKL1 is responsible primarily for the response to osmotic stress
physiological function
isoform TKL2 is responsible primarily for the response to oxidative stress
physiological function
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the enzyme plays an important role in the proliferation of metastatic ovarian cancer cells
physiological function
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the enzyme vital for Pyropia haitanensis desiccation tolerance. Transgenic Chlamycomonas reinhardtii cells overexpressing the enzyme from Pyropia haitanensis grow better than the wild type cells in response to osmotic stress
physiological function
Moniliella megachiliensis SN-124A
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isoform TKL2 is responsible primarily for the response to oxidative stress
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physiological function
Moniliella megachiliensis SN-124A
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isoform TKL1 is responsible primarily for the response to osmotic stress
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