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2.2.1.1: transketolase

This is an abbreviated version!
For detailed information about transketolase, go to the full flat file.

Word Map on EC 2.2.1.1

Reaction

sedoheptulose 7-phosphate
+
D-glyceraldehyde 3-phosphate
=
D-ribose 5-phosphate
 +
D-xylulose 5-phosphate

Synonyms

glycolaldehydetransferase, STM14_2885, STM14_2886, TK16, TKA, TKL, TKL1, Tkl2, TKT, TKT10, TKT3, TKT7, TktA, TktB, TKTc, TKTL-1, TKTL1, TKTL2, TKTp, transketolase, transketolase 10, transketolase 3, transketolase 7, transketolase A, transketolase B, transketolase like 1, transketolase-1, transketolase-like 1, transketolase-like enzyme 1, transketolase-like-1, transketolase-like-1-gene, transketolase-like-2

ECTree

     2 Transferases
         2.2 Transferring aldehyde or ketonic groups
             2.2.1 Transketolases and transaldolases
                2.2.1.1 transketolase

Substrates Products

Substrates Products on EC 2.2.1.1 - transketolase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2 D-xylulose 5-phosphate
glyceraldehyde 3-phosphate + glycolaldehyde
show the reaction diagram
-
reversible single substrate reaction, about 6% of the double-substrate reaction rate
-
-
?
2 hydroxypyruvate
2 glyoxylic acid + erythrulose
show the reaction diagram
-
-
-
-
ir
2 propanal + 2 lithium beta-hydroxypyruvate
(3S)-1,3-dihydroxypentan-2-one + (3R)-1,3-dihydroxypentan-2-one + 2 CO2 + 2 Li+
show the reaction diagram
2 pyruvate
erythrulose
show the reaction diagram
-
-
-
?
2-deoxy-D-erythrose 4-phosphate + ?
?
show the reaction diagram
-
-
-
-
?
2-deoxy-D-ribose 5-phosphate + ?
?
show the reaction diagram
-
-
-
-
?
2-methoxyethanal + glycolaldehyde
(3S)-1,3-dihydroxy-4-methoxybutan-2-one
show the reaction diagram
-
-
-
?
2-phenylethanal + hydroxypyruvate
(S)-1,3-dihydroxy-4-phenylbutan-2-one + CO2
show the reaction diagram
-
-
-
-
ir
3-formylbenzoic acid + hydroxypyruvate
3-(1,3-dihydroxy-2-oxopropyl)benzoic acid + CO2
show the reaction diagram
-
-
-
-
?
3-formylbenzoic acid + pyruvate
3-(2-oxopropanoyl)benzoate + CO2
show the reaction diagram
-
-
-
?
3-formylbenzoic acid + pyruvate
3-(2-oxopropanoyl)benzoic acid + CO2
show the reaction diagram
-
-
-
ir
3-hydroxybenzaldehyde + hydroxypyruvate
1,3-dihydroxy-1-(3-hydroxyphenyl)propan-2-one + CO2
show the reaction diagram
-
-
-
-
?
3-hydroxypyruvate + n-pentanal
1,3-dihydroxy-2-heptanone + CO2
show the reaction diagram
3% yield after 1 h (92% (S)), 12% yield after 3 h (87% (S))
-
-
ir
3-hydroxypyruvate + propanal
1,3-dihydroxy-2-pentanone + CO2
show the reaction diagram
12% yield after 1 h (57% (S)), 32% yield after 3 h (53% (S))
-
-
ir
3-phenylpropanal + hydroxypyruvate
(S)-1,3-dihydroxy-5-phenylpentan-2-one + CO2
show the reaction diagram
-
-
-
-
ir
4-formylbenzoic acid + hydroxypyruvate
4-(1,3-dihydroxy-2-oxopropyl)benzoic acid + CO2
show the reaction diagram
-
-
-
-
?
benzaldehyde + hydroxypyruvate
(R)-1,3-dihydroxy-1-phenylpropan-2-one + CO2
show the reaction diagram
-
the wild type enzyme shows very little activity against benzaldehyde
-
-
ir
beta-hydroxypyruvate + ?
?
show the reaction diagram
-
-
-
-
?
beta-hydroxypyruvate + glycolaldehyde
L-erythrulose + CO2
show the reaction diagram
butanal + glycolaldehyde
(3S)-1,3-dihydroxyhexan-2-one
show the reaction diagram
-
-
-
?
butanal + hydroxypyruvate
1,3-dihydroxyhexan-2-one + CO2
show the reaction diagram
-
-
-
?
butyraldehyde + hydroxypyruvate
? + CO2
show the reaction diagram
-
-
-
?
D-arabinose 5-phosphate + ?
?
show the reaction diagram
-
-
-
-
?
D-erythrose + ?
?
show the reaction diagram
-
-
-
-
?
D-erythrose 4-phosphate + ?
?
show the reaction diagram
D-erythrose 4-phosphate + D-xylulose 5-phosphate
?
show the reaction diagram
D-erythrose 4-phosphate + D-xylulose 5-phosphate
D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate
show the reaction diagram
D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate
D-erythrose 4-phosphate + D-xylulose 5-phosphate
show the reaction diagram
D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate
erythrose 4-phosphate + D-xylulose 5-phosphate
show the reaction diagram
D-fructose 6-phosphate + D-ribose 5-phosphate
?
show the reaction diagram
D-fructose 6-phosphate + D-ribose 5-phosphate
D-erythrose 4-phosphate + sedoheptulose 7-phosphate
show the reaction diagram
-
-
-
?
D-fructose 6-phosphate + Fe(CN)3-
glycolic acid + D-erythrose 4-phosphate + Fe(CN)64- + H+
show the reaction diagram
D-glucose 6-phosphate + D-fructose-6-phosphate
octulose 8-phosphate + ?
show the reaction diagram
-
reaction catalyzed by transketolase 7 and 10, but not transketolase 3
-
-
?
D-glucose 6-phosphate + hydroxypyruvate
2-D-glycero-D-ido-octulose phosphate + ?
show the reaction diagram
-
reaction is catalyzed by either isoform Tkt7 or isoform Tkt10 or both
-
-
?
D-glyceraldehyde + hydroxypyruvate
D-ribulose + ?
show the reaction diagram
-
-
-
?
D-glyceraldehyde + hydroxypyruvate
D-xylulose + CO2
show the reaction diagram
-
-
-
?
D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate
D-erythrose 4-phosphate + D-xylulose 5-phosphate
show the reaction diagram
-
-
-
?
D-lactaldehyde + hydroxypyruvate
5-deoxy-D-ribulose + ?
show the reaction diagram
-
-
-
?
D-ribose + ?
?
show the reaction diagram
-
-
-
-
?
D-ribose + hydroxypyruvate
? + CO2
show the reaction diagram
-
-
-
?
D-ribose 5-phosphate + 2,3-dihydroxy-4-O-(2'-oxo-benzopyran-7'-yl)-D-threose
?
show the reaction diagram
-
fluorogenic substrate as probe for measuring wild-type or altered transketolase activity from variants with improved or new properties acquired by random mutagenesis
-
-
?
D-ribose 5-phosphate + 7'-(2,3,5-trihydroxy-4-oxo-pentyl)oxycoumarin
?
show the reaction diagram
-
fluorogenic substrate as probe for measuring wild-type or altered transketolase activity from variants with improved or new properties acquired by random mutagenesis
-
-
?
D-ribose 5-phosphate + 7-(2',3',5'-trihydroxy-4'-oxo-pentyl)oxycoumarine
?
show the reaction diagram
-
fluorogenic substrate as probe for measuring wild-type or altered transketolase activity from variants with improved or new properties acquired by random mutagenesis
-
-
?
D-ribose 5-phosphate + D-xylulose 5-phosphate
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
show the reaction diagram
D-ribose-5-phosphate + L-erythrulose
D-sedoheptulose 7-phosphate + glycolaldehyde
show the reaction diagram
-
-
-
?
D-threose 4-phosphate + ?
?
show the reaction diagram
-
-
-
-
?
D-xylose + ?
?
show the reaction diagram
-
-
-
-
?
D-xylulose 5-phosphate + D-erythrose 4-phosphate
D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate
show the reaction diagram
D-xylulose 5-phosphate + D-ribose 5-phosphate
?
show the reaction diagram
-
-
-
?
D-xylulose 5-phosphate + D-ribose 5-phosphate
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
show the reaction diagram
D-xylulose-5-phosphate + D-ribose-5-phosphate
?
show the reaction diagram
-
-
-
?
DL-glyceraldehyde + ?
?
show the reaction diagram
-
-
-
-
?
DL-glyceraldehyde + hydroxypyruvate
? + CO2
show the reaction diagram
-
-
-
?
DL-glyceraldehyde 3-phosphate + ?
?
show the reaction diagram
formaldehyde + ?
?
show the reaction diagram
-
-
-
-
?
fructose 6-phosphate + ?
?
show the reaction diagram
fructose 6-phosphate + D-glyceraldehyde 3-phosphate
D-erythrose 4-phosphate + D-xylulose 5-phosphate
show the reaction diagram
-
-
-
-
r
fructose-6-phosphate + hydroxypyruvate
?
show the reaction diagram
-
-
-
-
?
glyceraldehyde 3-phosphate + D-glyceraldehyde 3-phosphate
D-xylulose 5-phosphate + D-xylulose 5-phosphate
show the reaction diagram
-
-
-
r
glycolaldehyde + ?
?
show the reaction diagram
-
-
-
-
?
glycolaldehyde + hydroxypyruvate
L-erythrulose + CO2
show the reaction diagram
-
-
-
?
glycolaldehyde + pyruvate
3,4-dihydroxy-2-butanone + CO2
show the reaction diagram
-
-
-
?
hexanal + 2-oxoheptanoic acid
7-hydroxydodecan-6-one + CO2
show the reaction diagram
-
-
-
?
hexanal + pyruvate
2-hydroxyheptanal + CO2
show the reaction diagram
-
-
-
?
hydroxypyruvate + ?
?
show the reaction diagram
-
-
-
-
?
hydroxypyruvate + D-glyceraldehyde 3-phosphate
CO2 + ribulose 5-phosphate
show the reaction diagram
hydroxypyruvate + D-ribose 5-phosphate
sedoheptulose 7-phosphate + ?
show the reaction diagram
-
-
-
-
?
hydroxypyruvate + D-ribose-5-phosphate
D-sedoheptulose 7-phosphate
show the reaction diagram
-
-
-
ir
hydroxypyruvate + ferricyanide + H2O
glycolic acid + ferrocyanide + ?
show the reaction diagram
-
-
-
-
?
hydroxypyruvate + glycolaldehyde
erythrulose + ?
show the reaction diagram
-
-
-
-
?
hydroxypyruvate + glycolaldehyde
L-erythrulose + ?
show the reaction diagram
hydroxypyruvate + ribose 5-phosphate
sedoheptulose 7-phosphate + ?
show the reaction diagram
L-arabinose + ?
?
show the reaction diagram
-
-
-
-
?
L-arabinose + lithium beta-hydroxypyruvate
L-gluco-heptulose + CO2 + Li+
show the reaction diagram
48% conversion after 24 h
-
-
?
L-erythrulose + D-ribose-5-phosphate
D-sedoheptulose 7-phosphate + glycolaldehyde
show the reaction diagram
-
-
-
?
L-erythrulose + ribose 5-phosphate
?
show the reaction diagram
-
-
-
-
?
L-glyceraldehyde + hydroxypyruvate
L-ribulose + ?
show the reaction diagram
minor reactivity
-
-
?
L-lactaldehyde + hydroxypyruvate
5-deoxy-L-ribulose + ?
show the reaction diagram
minor reactivity
-
-
?
L-lyxose + ?
?
show the reaction diagram
-
-
-
-
?
Li-hydroxypyruvate + propionaldehyde
1,3-dihydroxypentan-2-one + ?
show the reaction diagram
-
-
-
-
?
lithium beta-hydroxypyruvate + glycolaldehyde
L-erythrulose + ?
show the reaction diagram
-
-
-
-
?
N-acetyl-O'-(2R,3S,5-trihydroxy-4-oxopentyl)-L-tyrosine ethyl ester + D-ribose 5-phosphate
N-acetyl-O-[(2R)-2-hydroxy-3-oxopropyl]-L-tyrosine + D-sedoheptulose 7-phosphate
show the reaction diagram
-
transketolase catalyzes the hydroxyacetyl group transfer from the donor substrate N-acetyl-O'-(2R,3S,5-trihydroxy-4-oxopentyl)-L-tyrosine ethyl ester to D-ribose-5-phosphate, the natural acceptor substrate of transketolase. Transketolase catalyzes C2-C3 bond cleavage from N-acetyl-O'-(2R,3S,5-trihydroxy-4-oxopentyl)-L-tyrosine ethyl ester
-
-
?
pentanal + 2-oxohexanoic acid
6-hydroxydecan-5-one + CO2
show the reaction diagram
-
-
-
?
pentanal + pyruvate
2-hydroxyhexanal + CO2
show the reaction diagram
-
-
-
?
propanal + glycolaldehyde
(3S)-1,3-dihydroxypentan-2-one
show the reaction diagram
propionaldehyde + 2-oxobutanoic acid
4-hydroxyhexan-3-one + CO2
show the reaction diagram
-
-
-
?
propionaldehyde + pyruvate
2-hydroxybutanal + CO2
show the reaction diagram
-
-
-
?
ribulose 5-phosphate + ribose 5-phosphate
a heptulose phosphate + glyceraldehyde 3-phosphate
show the reaction diagram
-
ribulose is cleaved and ribose acts as acceptor
-
-
?
sedoheptulose 7-phosphate + ?
?
show the reaction diagram
-
-
-
-
?
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
D-ribose 5-phosphate + D-xylulose 5-phosphate
show the reaction diagram
additional information
?
-