2.4.2.29: tRNA-guanosine34 preQ1 transglycosylase

This is an abbreviated version!
For detailed information about tRNA-guanosine34 preQ1 transglycosylase, go to the full flat file.

Reaction

Synonyms

ArcTGT, guanine insertion enzyme, guanine, queuine-tRNA transglycosylase, Q-insertase, QTRT1, QueTGT, queuine insertase, queuine tRNA ribosyltransferase, queuine tRNA-ribosyltransferase, queuine tRNA-ribosyltransferase subunit 1, ribosyltransferase, queuine transfer ribonucleate, TGT, transfer ribonucleate glycosyltransferase, tRNA guanine transglycosidase, tRNA guanine transglycosylase, tRNA transglycosylase, tRNA-guanine 34 transglycosylase, tRNA-guanine transglycosylase, tRNA�guanine transglycosylase, virulence-associated protein VACC

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.2 Pentosyltransferases

                2.4.2.29 tRNA-guanosine34 preQ1 transglycosylase

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Results	in table
34820	AA Sequence
1	Application
1	CAS Registry Number
8	Cloned(Commentary)
10	Crystallization (Commentary)
65	Disease/ Diagnostics
2	General Information
109	Inhibitors
4	kcat/KM [mM/s]
79	Ki Value [mM]
36	KM Value [mM]
2	Localization
2	Metals/Ions
14	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
39	Organism
2	Pathway
213	PDB ID
1	pH Optimum
1	pH Range
12	Protein Variants
7	Purification (Commentary)
1	Reaction
1	Reaction Type
38	Reference
8	Source Tissue
1	Specific Activity [micromol/min/mg]
34	Substrates and Products (Substrate)
5	Subunits
48	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
29	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 2.4.2.29 - tRNA-guanosine34 preQ1 transglycosylase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

guanine34 in tRNA + 7-aminomethyl-7-carbaguanine

7-aminomethyl-7-carbaguanine34 in tRNA + guanine

6 entries

guanine34 in tRNA + queuine

queuine34 in tRNA + guanine

Homo sapiens

Q9BXR0

-

758889

-

-

?

additional information

?

-

4 entries

guanine34 in tRNA + 7-aminomethyl-7-carbaguanine

7-aminomethyl-7-carbaguanine34 in tRNA + guanine

Escherichia coli

-

the enzyme catalyzes the posttranscriptional base exchange of the queuosine precursor 7-(aminomethyl)-7-deazaguanine with the genetically encoded guanine in tRNAASp, tRNAAsn, tRNAHis and tRNATyr

644934

-

644934

?

guanine34 in tRNA + 7-aminomethyl-7-carbaguanine

7-aminomethyl-7-carbaguanine34 in tRNA + guanine

Escherichia coli

-

the enzyme exchanges the genetically encoded guanine at position 34 with a queuine precursor 7-(aminomethyl)-7-deazaguanine

644937

-

-

?

guanine34 in tRNA + 7-aminomethyl-7-carbaguanine

7-aminomethyl-7-carbaguanine34 in tRNA + guanine

Escherichia coli

-

the enzyme is responsible for the posttranscriptional modification of specific tRNAs (Asn, Asp, His and Tyr) with queuine. The enzyme catalyzes base exchange of guanosine34 with 7-aminomethyl-7-deazaguanine

644920

-

-

?

guanine34 in tRNA + 7-aminomethyl-7-carbaguanine

7-aminomethyl-7-carbaguanine34 in tRNA + guanine

Plasmodium falciparum

-

-

736521

-

-

?

guanine34 in tRNA + 7-aminomethyl-7-carbaguanine

7-aminomethyl-7-carbaguanine34 in tRNA + guanine

Shigella flexneri

-

the enzyme is involved in the hypermodification of cognate tRNAs, leading to the exchange of G34 by 7-methylamino-7-deazaguanine at the wobble position in the anticodon loop

644928

-

-

?

guanine34 in tRNA + 7-aminomethyl-7-carbaguanine

7-aminomethyl-7-carbaguanine34 in tRNA + guanine

Zymomonas mobilis

P28720

-

681439

-

-

?

additional information

?

-

Escherichia coli

-

post-translational modification of tRNA

644917

-

-

?

additional information

?

-

Escherichia coli

-

formation of queuosine

644917

-

-

?

additional information

?

-

Homo sapiens

-

higher expression of the subunit TGT60KD in cancer cells than in normal cells. The expression levels of the TGT60KD subunit regulate enzyme activity and the level of queuosine. TGT60KD plays significant roles in carcinogenesis

644929

-

-

?

additional information

?

-

Homo sapiens

-

the 60000 Da subunit of the enzyme plays a role in colon carcinogenesis

658379

-

-

?