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2.5.1.108: 2-(3-amino-3-carboxypropyl)histidine synthase

This is an abbreviated version!
For detailed information about 2-(3-amino-3-carboxypropyl)histidine synthase, go to the full flat file.

Word Map on EC 2.5.1.108

Reaction

S-adenosyl-L-methionine
+
L-histidine-[translation elongation factor 2]
=
S-methyl-5'-thioadenosine
 +
2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]

Synonyms

diphthamide biosynthesis protein 2, diphthine synthase, Dph1-Dph2, Dph2, DPH4, PhDph2, S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.108 2-(3-amino-3-carboxypropyl)histidine synthase

Natural Substrates Products

Natural Substrates Products on EC 2.5.1.108 - 2-(3-amino-3-carboxypropyl)histidine synthase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
5'-deoxy-5'-(3-(3-N,N-dimethylamino)phenoxy)propyl-5'-methyl-5'-thioadenosine + a protein
5'-deoxy-5'-(3-(3-N,N-dimethylamino)phenoxy)propyl-5'-thioadenosine + a methylated protein
show the reaction diagram
-
-
-
-
?
5'-deoxy-5'-(3-phenoxy)propyl-5'-methyl-5'-thioadenosine + a protein
5'-deoxy-5'-(3-phenoxy)propyl-5'-thioadenosine + a methylated protein
show the reaction diagram
-
-
-
-
?
L-histidine-[translation elongation factor 2] + S-adenosyl-L-methionine
2-((3S)-3-amino-3-carboxypropyl)-L-histidine-[translation elongation factor 2] + S-methyl-5'-thioadenosine
show the reaction diagram
S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2]
S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]
show the reaction diagram
S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2]
S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-carboxypropyl]-L-histidine-[translation elongation factor 2]
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + L-histidine600-[translation elongation factor 2]
S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine500-[translation elongation factor 2]
show the reaction diagram
the enzyme is involved in diphthamide biosynthesis
-
-
?
S-adenosyl-L-methionine + L-histidine600-[translation elongation factor 2]
S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine600-[translation elongation factor 2]
show the reaction diagram
the enzyme is involved in diphthamide biosynthesis
-
-
?
S-adenosyl-L-methionine + L-histidine699-[translation elongation factor 2]
S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine699-[translation elongation factor 2]
show the reaction diagram
the enzyme is involved in diphthamide biosynthesis
-
-
?
S-adenosyl-L-methionine + L-histidine715-[translation elongation factor 2]
S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine715-[translation elongation factor 2]
show the reaction diagram
the enzyme is involved in diphthamide biosynthesis
-
-
?