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2.5.1.15: dihydropteroate synthase

This is an abbreviated version!
For detailed information about dihydropteroate synthase, go to the full flat file.

Word Map on EC 2.5.1.15

Reaction

(7,8-dihydropterin-6-yl)methyl diphosphate
+
4-Aminobenzoate
=
diphosphate
 +
7,8-dihydropteroate

Synonyms

6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase, 6-hydroxymethyl-7,8-dihydropterin-pyrophosphokinase-dihydropteroate synthase, 6-hydroxymethyl-7,8-dihydropteroate synthase, 7,8-dihydropteroate synthase, 7,8-dihydropteroate synthetase, 7,8-dihydropteroic acid synthetase, BCG3672c, DHP synthase, DHPS, DHPS-HPPK, DHPS/DHPR, dihydroneopterin aldolase-dihydropterin pyrophosphokinase-dihydropteroate synthase, dihydropteroate diphosphorylase, dihydropteroate synthase, dihydropteroate synthase/hydroxymethyldihydropterin pyrophosphokinase, dihydropteroate synthetase, dihydropteroic synthetase, FolP, folP1, folP2, HPPK-DHPS, hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase, MbDHPS, MtDHPS, Mycobacterium tuberculosis dihydropteroate synthase, PfDHPS, pfPPK-DHPS, PPPK-DHPS, putative dihydropteroate synthase ortholog, pvdhps, PvHPPK-DHPS, PVX_123230, Rv1207, synthase, dihydropteroate

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.15 dihydropteroate synthase

KM Value

KM Value on EC 2.5.1.15 - dihydropteroate synthase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0036 - 0.0514
(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate
0.0004 - 0.00122
2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
0.0014 - 0.0019
2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate
0.00015 - 0.00443
4-Aminobenzoate
0.0025 - 0.0028
4-Aminobenzoic acid
0.0027
6-hydroxymethyl-7,8-dihydropterin diphosphate
100 microM 4-aminobenzoate, 25 °C
0.03
6-hydroxymethyldihydropteridine diphosphate
-
-
0.000058
dapson
in absence of 4-aminobenzoate
0.0026 - 0.008
p-Aminobenzoate
0.00037 - 4.02
p-Aminobenzoic acid
0.00289
Sulfadiazine
in absence of 4-aminobenzoate
0.0007
sulfamethizole
in absence of 4-aminobenzoate
0.00012 - 0.0027
sulfamethoxazole
0.0006 - 0.0048
sulfanilamide
0.00033 - 0.001
sulfathiazole
0.0015
sulfisoxazole
in absence of 4-aminobenzoate
additional information
additional information
-