2.5.1.15: dihydropteroate synthase

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For detailed information about dihydropteroate synthase, go to the full flat file.

Word Map on EC 2.5.1.15

2.5.1.15

plasmodium

falciparum

malaria

dihydrofolate

pfdhfr

sulfadoxine-pyrimethamine

chloroquine

antimalarial

pneumocystis

pfcrt

antifolate

sulfonamide

pyrimethamine

pfmdr1

uncomplicated

sulfadoxine

quintuple

vivax

artemisinin

jirovecii

sulfa

pcp

dapsone

artemisinin-based

carinii

trimethoprim

p-aminobenzoic

leprae

artesunate

sulfamethoxazole

gyras

paba

amodiaquine

trimethoprim-sulfamethoxazole

artemether-lumefantrine

chloroquine-resistant

mefloquine

sextuple

resistance-mediating

biotechnology

multibacillary

malaria-endemic

cycloguanil

piperaquine

molecular biology

para-aminobenzoic

medicine

atovaquone

drug development

antifolate-resistant

tmp-smx

sulfathiazole

lumefantrine

sulfanilamide

Reaction

(7,8-dihydropterin-6-yl)methyl diphosphate

Synonyms

6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase, 6-hydroxymethyl-7,8-dihydropterin-pyrophosphokinase-dihydropteroate synthase, 6-hydroxymethyl-7,8-dihydropteroate synthase, 7,8-dihydropteroate synthase, 7,8-dihydropteroate synthetase, 7,8-dihydropteroic acid synthetase, BCG3672c, DHP synthase, DHPS, DHPS-HPPK, DHPS/DHPR, dihydroneopterin aldolase-dihydropterin pyrophosphokinase-dihydropteroate synthase, dihydropteroate diphosphorylase, dihydropteroate synthase, dihydropteroate synthase/hydroxymethyldihydropterin pyrophosphokinase, dihydropteroate synthetase, dihydropteroic synthetase, FolP, folP1, folP2, HPPK-DHPS, hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase, MbDHPS, MtDHPS, Mycobacterium tuberculosis dihydropteroate synthase, PfDHPS, pfPPK-DHPS, PPPK-DHPS, putative dihydropteroate synthase ortholog, pvdhps, PvHPPK-DHPS, PVX_123230, Rv1207, synthase, dihydropteroate

ECTree

2 Transferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

2.5.1.15 dihydropteroate synthase

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Results	in table
4	Activating Compound
36488	AA Sequence
12	Application
1	CAS Registry Number
32	Cloned(Commentary)
2	Cofactor
18	Crystallization (Commentary)
25	General Information
18	IC50 Value
282	Inhibitors
16	kcat/KM [mM/s]
138	Ki Value [mM]
65	KM Value [mM]
5	Localization
11	Metals/Ions
24	Molecular Weight [Da]
61	Natural Substrates/ Products (Substrates)
114	Organism
6	Pathway
162	PDB ID
14	pH Optimum
3	pH Range
1	pH Stability
1	pI Value
93	Protein Variants
30	Purification (Commentary)
4	Reaction
7	Reaction Type
99	Reference
11	Source Tissue
25	Specific Activity [micromol/min/mg]
8	Storage Stability
109	Substrates and Products (Substrate)
14	Subunits
144	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
35	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 2.5.1.15 - dihydropteroate synthase

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110000

Saccharomyces cerevisiae

P53848

recombinant bifunctional fusion protein encoding dihydropterin pyrophosphokinase and dihyropteroate synthase domains of the trifunctional enzyme dihydroneopterin aldolase-dihydropterin pyrophosphokinase-dihydropteroate synthase, gel filtration

174000

gel filtration

190000

Sephadex chromatography

639668, 639670

222000

Plasmodium falciparum

gel filtration

639673

280000 - 300000

Pisum sativum

gel filtration

639674

29000

Mycobacterium tuberculosis

P9WNC9, P9WND1

recombinant, hexa-His tagged enzyme, SDS-PAGE

692394

30000

Escherichia coli MC4100

P0AC13

2 * 30000, SDS-PAGE

639671

33000

Mycobacterium tuberculosis

P9WNC9, P9WND1

recombinant, hexa-His tagged enzyme, SDS-PAGE

692394

34070

Mycobacterium tuberculosis

P9WNC9, P9WND1

deduced from primary structure

692394

50000

Escherichia coli

gel filtration

639665

50509

Francisella tularensis

1 * 50509, sequence calculation

723522

52000

Escherichia coli

polyacrylamide gel electrophoresis

639666

52000 - 54000

Escherichia coli MC4100

gel filtration

53000

60000

61300

Staphylococcus aureus

O05701

639675

68000

Burkholderia cenocepacia

A0A0H2XP43

recombinant enzyme, gel filtration

721948

71500

Pneumocystis carinii

polyacrylamide gel electrophoresis

5108

75000

Mycobacterium tuberculosis

P9WNC9, P9WND1

recombinant hexa-His tagged enzyme, gel filtration chromatography

692394

83000

Plasmodium falciparum

bifunctional hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase, gel filtration

662800

86000

Plasmodium falciparum

Q25704

759184