2.5.1.22: spermine synthase

This is an abbreviated version!
For detailed information about spermine synthase, go to the full flat file.

Word Map on EC 2.5.1.22

2.5.1.22

polyamine

putrescine

s-adenosylmethionine

ornithine

aminopropyltransferases

snyder-robinson

alpha-difluoromethylornithine

acaulis5

thermospermine

trans-4-methylcyclohexylamine

gyro

kyphoscoliosis

agriculture

adometdc

2.5.1.16

medicine

Reaction

S-adenosyl 3-(methylsulfanyl)propylamine

Synonyms

ACL5, aminopropyltransferase, spermidine, OsSPMS1, SMS, spermidine aminopropyltransferase, spermine synthase, spermine synthase 1, spermine synthetase, Spm synthase, SpmS, SPMS1, SpmSyn, synthase, spermine

ECTree

2 Transferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

2.5.1.22 spermine synthase

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Results	in table
1	Activating Compound
42	AA Sequence
5	Application
1	CAS Registry Number
12	Cloned(Commentary)
2	Cofactor
3	Crystallization (Commentary)
122	Disease/ Diagnostics
5	Expression
14	General Information
1	General Stability
4	IC50 Value
66	Inhibitors
7	Ki Value [mM]
23	KM Value [mM]
8	Localization
2	Metals/Ions
10	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
550	Organism
8	Pathway
14	PDB ID
6	pH Optimum
36	Protein Variants
11	Purification (Commentary)
2	Reaction
2	Reaction Type
56	Reference
65	Source Tissue
14	Specific Activity [micromol/min/mg]
1	Storage Stability
51	Substrates and Products (Substrate)
15	Subunits
37	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
10	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 2.5.1.22 - spermine synthase

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H2N(CH2)3NH(CH2)4NH2 + S-adenosyl 3-(methylthio)propylamine

H2N(CH2)3NH(CH2)4NH(CH2)3NH2 + S-methyl-5'-thioadenosine

Homo sapiens

708060

S-adenosyl 3-(methylthio)propylamine + spermidine

S-methyl-5'-thioadenosine + spermine

6 entries

S-adenosyl-L-methioninamine + spermidine

5'-methylthioadenosine + spermine

5 entries

S-adenosylmethioninamine + 1,8-diaminooctane

5'-methylthioadenosine + N-(3-aminopropyl)octane-1,8-diamine

Rattus norvegicus

poor substrate

489861

S-adenosylmethioninamine + 6,6-difluorospermidine

5'-methylthioadenosine + 6,6-difluorospermine

Rattus norvegicus

489869

S-adenosylmethioninamine + 6-monofluorospermidine

5'-methylthioadenosine + 6-monofluorospermine

Rattus norvegicus

489869

S-adenosylmethioninamine + 7,7-difluorospermidine

5'-methylthioadenosine + 7,7-difluorospermine

Rattus norvegicus

489869

S-adenosylmethioninamine + 7-monofluorospermidine

5'-methylthioadenosine + 7-monofluorospermine

Rattus norvegicus

489869

S-adenosylmethioninamine + N-(3-aminopropyl)cadaverine

5'-methylthioadenosine + ?

Rattus norvegicus

poor substrate

489861

S-adenosylmethioninamine + spermidine

5'-methylthioadenosine + spermine

16 entries

S-adenosylmethioninamine + spermidine

5'-methylthioadenosine + spermine + H+

Homo sapiens

P52788

Polyamine sythesis, addition of a second aminopropyl group to the N-10 position of spermidine. The active site with a bound spermidine molecule contains an Asp276 residue, which is in an ideal position to facilitate the deprotonation of the N-10 amino group of spermidine that attacks the C-atom of the aminopropyl group of decarboxylated S-adenosylmethionine

692270

S-adenosylmethioninamine + spermidine

S-methyl-5'-thioadenosine + spermine

4 entries

S-adenosylmethioninamine + sym-homospermidine

5'-methylthioadenosine + ?

Rattus norvegicus

17% of the activity with spemidine

489861

S-adenosylmethioninamine + sym-norspermidine

5'-methylthioadenosine + ?

Rattus norvegicus

poor substrate

489861

additional information

10 entries