2.5.1.46: deoxyhypusine synthase
This is an abbreviated version!
For detailed information about deoxyhypusine synthase, go to the full flat file.
Word Map on EC 2.5.1.46
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2.5.1.46
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polyamine
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gc7
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homospermidine
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pyrrolizidine
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n1-guanyl-1,7-diaminoheptane
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nepsilon-4-amino-2-hydroxybutyllysine
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aminobutylation
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hypusine-containing
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1,7-diaminoheptane
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deoxyhypusine-containing
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butylamine
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polyamine-derived
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eif-4d
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medicine
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1,3-diaminopropane
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triamine
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wolff
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drug development
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analysis
- 2.5.1.46
- polyamine
- gc7
- homospermidine
-
pyrrolizidine
- n1-guanyl-1,7-diaminoheptane
-
nepsilon-4-amino-2-hydroxybutyllysine
-
aminobutylation
-
hypusine-containing
- 1,7-diaminoheptane
-
deoxyhypusine-containing
- butylamine
-
polyamine-derived
-
eif-4d
- medicine
- 1,3-diaminopropane
- triamine
-
wolff
- drug development
- analysis
Reaction
Synonyms
CpDHS, deoxyhypusine synthase, deoxyhypusine synthase (Caulobacter crescentus gene CC0359), deoxyhypusine synthase (Halobacterium strain NRC-1 gene dhs), deoxyhypusine synthase (human clone 30649 gene DHPS subunit reduced), deoxyhypusine synthase (Nicotiana tabacum gene DHS1), deoxyhypusine synthase (Senecio vernalis gene DHS1), deoxyhypusinesynthase, DHPS, DHS, DHS1, DHS2, DHS20, DHS34, DHSc, DHSp, DHYS, Dys1, Dys1p, EC 1.1.1.249, HVO 2297, PF3D7_1412600, speY, synthase, deoxyhypusine, TbDHSc, TbDHSp
ECTree
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Cofactor
Cofactor on EC 2.5.1.46 - deoxyhypusine synthase
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NAD+
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one enzyme tetramer can bind up to four each of NAD+ and spermidine, the binding of spermidine being dependent on NAD+
NAD+
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the NADH generated in the first step of the reaction remains enzyme-associated during the reaction and the hydride ion generated by the oxidation of spermidine is preserved for the reduction of the eIF5A-imine intermediate
NAD+
required, Km value is 0.082 mM, kcat is 0.018/s for the heterotetrameric DHS
NAD+
each enzyme heterodimer contains two NAD+ binding sites, one housed in the functional catalytic site and the second bound in a remnant dead site that lacks key catalytic residues
NADH
there is a measurable release of enzyme-bound NADH in the absence of eIF5A precursor. The NADH:DHS ratio is around 6