2.5.1.56: N-acetylneuraminate synthase
This is an abbreviated version!
For detailed information about N-acetylneuraminate synthase, go to the full flat file.
Word Map on EC 2.5.1.56
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2.5.1.56
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n-acetylmannosamine
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antifreeze
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mannac
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meningitidis
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polysialic
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neunacs
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neuroinvasive
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synthesis
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cmp-sialic
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2-epimerase
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ice-binding
- 2.5.1.56
- n-acetylmannosamine
-
antifreeze
- mannac
- meningitidis
-
polysialic
-
neunacs
-
neuroinvasive
- synthesis
-
cmp-sialic
-
2-epimerase
-
ice-binding
Reaction
Synonyms
(NANA) condensing enzyme, EC 4.1.3.19, N-acetylneuraminate lyase synthase, N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating), N-acetylneuraminic acid condensing enzyme, N-acetylneuraminic acid synthase, NANA condensing enzyme, NANA synthase, NANAS, NANS, NeuAc synthase, NeuB, NeuB1, NeuNAc synthase, NmeNANAS, sialic acid synthase, synthase, N-acetylneuraminate
ECTree
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Temperature Stability
Temperature Stability on EC 2.5.1.56 - N-acetylneuraminate synthase
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40 - 60
purified recombinant enzyme, pH 8.0, reasonably stable, maintaining 60% activity after 4 h at 40, and 50% activity after 30 min at 50°C, and almost fully inactivated at 60°C after 1 h
50
additional information
the enzyme from a psychrophilic bacterium, MvNeuB, is less stable at higher temperature and has a high catalytic activity at lower temperature compared to mesophilic counterparts. MvNeuB is a typical cold adapted enzyme
additional information
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the enzyme from a psychrophilic bacterium, MvNeuB, is less stable at higher temperature and has a high catalytic activity at lower temperature compared to mesophilic counterparts. MvNeuB is a typical cold adapted enzyme
additional information
the wild-type apoenzyme has a higher melting temperature of 42.6°C compared to the mutant G272Term apoenzyme with 36.5°C. Unlike the wild-type enzyme, the melting temperature of mutant G272Term in the presence of Mn2+ remains consistent and is not influenced by the addition of different ligand combinations. The melting temperature of wild-type NmeNANAS increases slightly in the presence of Mn2+
additional information
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the wild-type apoenzyme has a higher melting temperature of 42.6°C compared to the mutant G272Term apoenzyme with 36.5°C. Unlike the wild-type enzyme, the melting temperature of mutant G272Term in the presence of Mn2+ remains consistent and is not influenced by the addition of different ligand combinations. The melting temperature of wild-type NmeNANAS increases slightly in the presence of Mn2+