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2.5.1.61: hydroxymethylbilane synthase

This is an abbreviated version!
For detailed information about hydroxymethylbilane synthase, go to the full flat file.

Word Map on EC 2.5.1.61

Reaction

4 porphobilinogen +

H2O
=
Hydroxymethylbilane
 + 4 NH3

Synonyms

(HMB)-synthase, AN0121.3, EC 4.3.1.8, HemC, hepatic porphobilinogen deaminase, HMB synthase, HMB-S, HMBS, HMBS1a-synthase, HMBS1b-synthase, HMBS2a-synthase, HMBS2b-synthase, human non-erythropoietic PBGD isoform, human PBGD, human porphobilinogen deaminase, hydroxymethylbilane synthase, More, PBG deaminase, PBG-D, PBG-deaminase, PBGD, PGB-D, porphobilinogen ammonia-lyase (polymerizing), porphobilinogen deaminase, pre-uroporphyrinogen synthase, preuroporphyrinogen synthase, preuroporphyrinogen synthetase, synthase, uroporphyrinogen I, uPBGD, UPGI-S, URO-S, urogenI synthase, uroporphyrinogen I synthase, uroporphyrinogen I synthetase, uroporphyrinogen synthase, uroporphyrinogen synthetase

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.61 hydroxymethylbilane synthase

pH Range

pH Range on EC 2.5.1.61 - hydroxymethylbilane synthase

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5 - 9
-
pH 5.0: unstable below, pH 9.0 stable above
6 - 10
-
pH 6.0: about 15% of maximal activity, pH 10.0: 25% of maximal activity
6 - 10.6
-
no activity below pH 6.0 and above pH 10.6
6 - 8
-
pH 6.0: enzyme is rapidly and irreversibly inactivated below, pH 8.0: about 50% of maximal activity
6 - 9
6.2 - 8.4
-
pH 6.2: 50% of maximal activity, pH 8.4: 30% of maximal activity
6.3 - 7.5
-
pH 6.3 and pH 7.5: 85% of maximal activity
6.5 - 9
-
pH 6.5: 25% of maximal activity, pH 9.0: 50% of maximal activity
6.5 - 9.2
-
50% of maximal activity at pH 6.5 and pH 9.2
additional information