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2.7.1.107: diacylglycerol kinase (ATP)

This is an abbreviated version!
For detailed information about diacylglycerol kinase (ATP), go to the full flat file.

Word Map on EC 2.7.1.107

Reaction

ATP
+
1,2-diacyl-sn-glycerol
=
ADP
 +
1,2-diacyl-sn-glycerol 3-phosphate

Synonyms

1,2-diacylglycerol kinase, 1,2-diacylglycerol kinase epsilon, adenosine 5'-triphosphate:1,2-diacylglycerol 3-phosphotransferase, arachidonoyl-specific diacylglycerol kinase, ATP:diacylglycerol phosphotransferase, DAG kinase, DAG-kinase, DAGK, DAGKalpha, DAGKepsilon, DG kinase, DGK, DGK zeta, DGK-1, DGK-3, DGK-3 diacylglycerol kinase, DGK-alpha, DGK-theta, DGK-zeta, DGK1, DGK2, DGK3, DGK4, DGK5, DGK6, DGK7, DGKA, DGKalpha, DgkB, DGKbeta, DGKdelta, DGKE, DGKepsilon, DGKeta, DGKeta1, DGKeta2, DGKeta3, DGKeta4, DGKgamma, DGKiota, DGKkappa, DGKksi, DGKtheta, DGKzeta, diacylglycerol kinase, diacylglycerol kinase (ATP dependent), diacylglycerol kinase 4, diacylglycerol kinase alpha, diacylglycerol kinase beta, diacylglycerol kinase delta, diacylglycerol kinase epsilon, diacylglycerol kinase eta, diacylglycerol kinase theta, diacylglycerol kinase zeta, diacylglycerol kinase-alpha, diacylglycerol kinase-epsilon, diacylglycerol kinase-zeta, diacylglycerol:ATP kinase, diglyceride kinase, epsilonDGK, eye-specific diacylglycerol kinase, kinase (phosphorylating), 1,2-diacylglycerol, kinase, 1,2-diacylglycerol (phosphorylating), OsDAGK1, Rv2252, sn-1,2-diacylglycerol kinase, type V DGK, YegS, YerQ

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.107 diacylglycerol kinase (ATP)

Activating Compound

Activating Compound on EC 2.7.1.107 - diacylglycerol kinase (ATP)

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(S)-2-amino-2-((S)-6-octyl-1,2,3,4-tetrahydronaphthalen-2-yl)propan-1-ol
-
analogue of FTY720, 0.01 mM increase phosphorylation of 1-O-hexadecyl-sn-2-acetyl glycerol by isoform diacylglycerol kinase alpha about 3.5fold.
1,3-dioleoylglycerol
-
activates
1-monooleoylglycerol
-
activates
1-O-alkylphosphatidylcholine
-
half-maximal activation at 21.9 mol%
1-palmitoyl-2-oleoylglycerophosphocholine
-
activates
4-(2,4-dimethylphenoxy)-N-hydroxybutanamide
0.1 mM KU-10 activates isoform DGKalpha by about 10%
-
4beta-phorbol-12-myristate-13-acetate
enhances voltage-dependent opening of wild-type and cAMP/H+-uncoupled hyperpolarization activated, cyclic nucleotide-regulated channels. 4beta-Phorbol-12-myristate-13-acetate exerts its effects on channel gating via sequential activation ofprotein kinase C and diacylglycerol kinase coupled with upregulation of mitogen-activated protein kinase and phospholipase A2
acidic phospholipids
-
activation in vitro
-
benzothiadiazole
activation of the expression of diacylglycerol kinase OsDAGK1
bis-phosphatidic acid
-
half-maximal activation at 3.9 mol%
-
cAMP
-
stimulates nuclear diacylglycerol kinase catalytic activity
cardiolipin
cholesterol
cholesterol 3-sulfate
-
activates
D-glucose
-
exposure of L6 cell myotubes overexpressing human insulin receptors to 25 mM glucose for 5 min decreases the intracellular levels of diacylglycerol, paralleled by transient activation of diacylglycerol kinase and of insulin receptor signaling. Following 30-min exposure, both diacylglycerol levels and diacylglycerol kinase activity return close to basal levels. Glucose exposure redistributes diacylglycerol kinase isoforms alpha and delta, from the prevalent cytosolic localization to the plasma membrane fraction
deoxycholate
detergent
-
no activity in absence of detergent
-
di-O-hexadecylphosphatidylcholine
-
half-maximal activation at 13.5 mol%
diacylglycerol 3-phosphate
-
the enzyme apoprotein is attributed to a novel feedback activation involving diacylglycerol 3-phosphate
dilauroyl-N,N-dimethylglycerophosphoethanolamine
-
activates
dilauroyl-N-methylglycerophosphoethanolamine
-
activates
dilauroylglycerophosphocholine
-
activates
dilauroylglycerophosphoethanolamine
-
activates
dilauroylphosphatidylcholine
-
half-maximal activation at 11.9 mol%
dimethylmyristamide
-
activates
dioleoyl ethylene glycol
-
activates
dioleoyl-phosphatidylglycerol
-
dioleoylphosphatidylcholine
-
half-maximal activation at 10.4 mol%
dioleoylphosphatidylglycerol
-
half-maximal activation at 6.3 mol%
dipalmitoylphosphatidic acid
-
activates only in presence of Triton X-100
endothelin-1
-
activates diacylglycerol kinase in caveolae/rafts and noncaveolae/rafts of mesenteric arteries. Activation does not depend on phosphatidylinositol 3-kinase. In response to norepinephrin, but not to epithelin-1, protein kinase PKB translocates to caveolae/rafts
epigallocatechin gallate
-
FTY720
-
in presence of 0.01 mM FTY720, phosphorylation of 1-O-hexadecyl-sn-2-acetyl glycerol by isoforms diacylglycerol kinase alpha, beta or gamma is 3fold increased
H2O2
-
endogenous nuclear diacylglycerol kinase zeta rapidly translocates to the cytoplasm following H2O2 treatment
hepatocyte growth factor
-
induces diaclyglycerol kinase activity, which is required for cell invasiveness
-
hexadecanol
-
activates
hexadecyl phosphorylcholine
-
half-maximal activation at 17.3 mol%
hexadecylphosphorylcholine
-
activates
lauryl maltoside
-
activates in presence of 11 mM Triton X-100
Lipid
-
purified enzyme is completely inactive unless a lipid is added to the assay buffer containing Triton X-100
lysophosphatidylcholine
-
activation of phospholipids in the order of decreasing efficiency: phosphatidylcholine, lysophosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingomyelin
lysophosphatidylethanolamine
-
activates
methyl myristate
-
activates
myristoylcholine chloride
-
activates
myristyl acetate
-
activates
n-hexyl beta-D-glucoside
-
activates in presence of 11 mM Triton X-100
N-[7-[cyclopropyl(hydroxy)methyl]-2,3-dihydro-1,4-benzodioxin-6-yl]cyclopropanecarboxamide
0.1 mM KU-8 activates isoform DGKalpha by 19%
-
nitrododecane
-
activates
norepinephrine
-
stimulates an increase in diacylglycerol kinase activity in caveolae/rafts of mesenteric arteries. Activation depends on phosphatidylinositol 3-kinase. In response to norepinephrin, but not to epithelin-1, protein kinase PKB translocates to caveolae/rafts
octyl acetate
-
activates
octyl beta-glucoside
-
activates in presence of 11 mM Triton X-100
oleic acid
-
activates only in presence of Triton X-100
oleoylcholine chloride
-
activates
palmitic acid
-
activates only in presence of Triton X-100
phorbol-12-myristate-13-acetate
diacylglycerol kinase zeta activity at the T cell receptor is enhanced by phorbol-12-myristate-13-acetate cotreatment
phosphatidic acid
phosphatidyl glycerol
-
good activator
phosphatidylcholine
phosphatidylcholine plasmalogen
-
half-maximal activation at 7.3 mol%
-
phosphatidylethanolamine
phosphatidylglycerol
-
effective stimulation
phosphatidylinositol
phosphatidylinositol 4,5-bisphosphate
-
highly stimulating
phosphatidylserine
Phospholipid
platelet-activating factor
-
half-maximal activation at 22.4 mol%
rac-1,2-dioleoylglycero-3-sulfate
-
half-maximal activation at 2.7 mol%
sn-1,2-dioleoylglycerol
-
activates
sn-1,3-dioleoylglycerol
-
activates
sodium cholate
-
enhances activity of DGK I and DGK IV
sodium deoxycholate
-
enhances activity of DGK I and DGK IV
Sodium dodecyl sulfate
-
activates
sodium hexadecyl sulfate
-
half-maximal activation at 9.8 mol%
Span-20
-
activates
sphingomyelin
-
activation of phospholipids in the order of decreasing efficiency: phosphatidylcholine, lysophosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingomyelin
sphingosine
stearic acid
-
activates only in presence of Triton X-100
stearoyllysophosphatidylcholine
-
half-maximal activation at 15.8 mol%
Triton X-100
-
activates
additional information
-