2.7.4.14: UMP/CMP kinase
This is an abbreviated version!
For detailed information about UMP/CMP kinase, go to the full flat file.
Word Map on EC 2.7.4.14
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2.7.4.14
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dcmp
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deoxycytidine
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gemcitabine
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cidofovir
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nmp-binding
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umpks
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medicine
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diagnostics
- 2.7.4.14
- dcmp
- deoxycytidine
- gemcitabine
- cidofovir
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nmp-binding
- umpks
- medicine
- diagnostics
Reaction
Synonyms
ATP:UMP-CMP phosphotransferase, CMP kinase, CMP/UMP kinase, CMPK, CMPK1, CMPK2, CTP:CMP phosphotransferase, cytidine monophosphate kinase, cytidine/uridine monophosphate kinase 2, cytidylate kinase, dCK, deoxycytidine kinase, EC 2.7.4.5, kinase, cytidylate (phosphorylating), More, MssA protein, nucleoside monophosphate kinase, P25, pyrimidine nucleoside monophosphate kinase, UCK, UMP-CMP kinase, UMP-CMP kinase 2, UMP-CMPK2, UMP/CMP kinase, UMP/CMP kinase 1, UMP/CMPK1, UMPK, uridine monophosphate/cytidine monophosphate kinase
ECTree
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Reaction
Reaction on EC 2.7.4.14 - UMP/CMP kinase
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ATP + UMP = ADP + UDP
reaction mechanism is sequential and nonequilibrium in nature, substrates bind to the enzyme in a random order, substrate binding is cooperative
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ATP + UMP = ADP + UDP
the mechanism is analogous to the phosphoryl transfer mechanism in cAMP-dependent protein kinase that phosphorylates the hydroxyl groups of serine residues
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ATP + UMP = ADP + UDP
formation of a ternary complex, addition of substrates is random
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ATP + UMP = ADP + UDP
reaction proceeds by a sequential mechanism, a ternary complex of the enzyme with both substrates is formed as the central intermediate in the reaction
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