2.7.7.9: UTP-glucose-1-phosphate uridylyltransferase
This is an abbreviated version!
For detailed information about UTP-glucose-1-phosphate uridylyltransferase, go to the full flat file.
Word Map on EC 2.7.7.9
-
2.7.7.9
-
phosphoglucomutase
-
polysaccharide
-
glycogen
-
galactose
-
udp-galactose
-
adp-glucose
-
exopolysaccharide
-
dictyostelium
-
udp-sugars
-
udp-n-acetylglucosamine
-
leloir
-
galactose-1-phosphate
-
udp-glucuronic
-
galactokinase
-
aureobasidium
-
pyrophosphorolysis
-
sucrose-phosphate
-
gellan
-
xylinum
-
agriculture
-
synthesis
-
medicine
- 2.7.7.9
- phosphoglucomutase
- polysaccharide
- glycogen
- galactose
- udp-galactose
- adp-glucose
- exopolysaccharide
- dictyostelium
- udp-sugars
- udp-n-acetylglucosamine
-
leloir
- galactose-1-phosphate
-
udp-glucuronic
- galactokinase
-
aureobasidium
-
pyrophosphorolysis
-
sucrose-phosphate
- gellan
- xylinum
- agriculture
- synthesis
- medicine
Reaction
Synonyms
All3274, CugP, cyanobacterial UDP-Glc PPase, ExoN, GalU, gfugp, Glc-1-P UTase, GlcNAc-1-P UTase, glucose 1-phosphate uridylyltransferase, glucose-1-phosphate urididyltransferase, glucose-1-phosphate uridyltransferase, glucose-1-phosphate uridylyltransferase, KF278717, plastid UDP-glucose pyrophosphorylase, rml-1, ScUGPase-1, sll1558, ST0452, ST0452 protein, STK_04520, sugar-1-P NTase, sugar-1-phosphate nucleotidylyltransferase, TaGalU, UDP glucose pyrophosphorylase, UDP-Glc pyrophosphorylase, UDP-GlcPPase, UDP-glucose pyrophosphorylase, UDP-glucose pyrophosphorylase 1, UDP-glucose pyrophosphorylase isoenzyme UGP5, UDP-glucose pyrophosphorylase UGP1, UDP-glucose pyrophosphorylase UGP2, UDP-glucose pyrophosphorylase UGP3, UDPG phosphorylase, UDPG pyrophosphorylase, UDPG-pyrophosphorylase, UDPglucose pyrophosphorylase, UDPGP, UGP, ugp-1, UGP1, UGP3, UgpA, UGPase, UGPase1, UGPase2, UGPG-PPase, UPD1, uridine 5'-diphosphoglucose pyrophosphorylase, uridine diphosphate-D-glucose pyrophosphorylase, uridine diphosphate-glucose pyrophosphorylase, uridine diphosphoglucose pyrophosphorylase, uridine-diphosphate glucose pyrophosphorylase, uridylyltransferase, glucose 1-phosphate, UTP/dTTP-glucose-1-phosphate uridylyl/thymidylyl transferase, UTP:alpha-D-glucose uridylyltransferase, UTP:glucose-1-phosphate uridylyltransferase, VldB
ECTree
2.7.7.9 UTP-glucose-1-phosphate uridylyltransferaseAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 2.7.7.9 - UTP-glucose-1-phosphate uridylyltransferase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
H2O2
complete loss of activity after 30 min, inactivation is reverted by reduction by cysteine and thioredoxin
hydrogen peroxide
-
inactivation is reversed by reduction with dithiothreitol or thioredoxin
iodoacetamide
-
wild-type: loss of 56% activity after 30 min at 0.1 mM, mutant C123S is not affected
NAD+
presence of either NAD or NADP results in a decrease of activity to about 80% or 50%, respectively
NADP+
presence of either NAD or NADP results in a decrease of activity to about 80% or 50%, respectively
sodium nitroprusside
complete loss of activity after 30 min, inactivation is reverted by reduction by cysteine and thioredoxin
Co2+
-
no effect on liver enzyme form I, 2fold activation of enzyme form from sublingual gland, inhibition of enzyme form from submandibular gland
Co2+
-
in excess of diphosphate-concentration, activates at lower concentrations
diphosphate
Q94B70
with 0.25 mM 57% activity, with 1 mM 11% activity, with 10 mM 1.5% activity
diphosphate
-
possible alternate regulatory mechanism; product inhibition
Mn2+
-
in excess of diphosphate-concentration, activates at lower concentrations
UDP
UGPase activity is not significantly decreases in A-549 cells treated with 0.0001-0.003 mM UDP. Activity is significantly decreased at 0.005 mM and 0.1 mM UDP treatments. The inhibition of UGPase activity in A549 cells is 28fold higher at 0.1 mM UDP treatment in comparison to 0.005 mM treatment
UDP
significant decrease in UGPase activity is observed at 0.002 mM UDP treatment. At 0.005 mM UDP, threefold inhibition is observed in UGPase activity in comparison to 0.1 mM. Comparative analysis of UDP treatment on blood isolate and reference D39 strain shows that 0.005 mM UDP treatments for 1 hour are effective to reduce the bacterial UGPase activity by half than in its host counterpart. UDP mediates decrease in the virulence of Streptococcus pneumoniae
UDP-glucose
-
UDP-galactose pyrophosphorolysis or UDP-glucose synthesis
UDP-glucose
-
competitive to UTP, noncompetitive to glucose 1-phosphate
additional information
structure-activity relationship of the salicylimide derived inhibitors
-
additional information
-
no effect of PCMB, iodoacetate, 2-mercaptoethanol or DTT
-
additional information
-
inhibition kinetics for UDP-sugars; little or no inhibition by alpha-D-mannose 1-phosphate, alpha-D-xylose 1-phosphate or alpha-D-glucuronic acid 1-phosphate
-
additional information
not inhibitory: 1 mM 2-oxoglutaric acid, 3-phosphoglyceric acid, and 5-aminolevulinic acid
-
