1.14.12.13: 2-halobenzoate 1,2-dioxygenase

This is an abbreviated version!
For detailed information about 2-halobenzoate 1,2-dioxygenase, go to the full flat file.

Word Map on EC 1.14.12.13

Reaction

a 2-halobenzoate +

NADH
+
H+
+
O2
=
catechol
+ a halide anion +
NAD+
+
CO2

Synonyms

(chloro)benzoate dioxygenase, 2-chlorobenzoate 1,2-dioxygenase, 2-halobenzoate 1,2-dioxygenase, 2-halobenzoate dioxygenase, 2-halobenzoate dioxygenase system, BenA, CbdAB, cbdABC

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
                1.14.12.13 2-halobenzoate 1,2-dioxygenase

Systematic Name

Systematic Name on EC 1.14.12.13 - 2-halobenzoate 1,2-dioxygenase

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SYSTEMATIC NAME
IUBMB Comments
2-halobenzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, dehalogenating, decarboxylating)
A multicomponent enzyme system composed of a dioxygenase component and an electron transfer component. The latter contains FAD. The enzyme, characterized from the bacterium Burkholderia cepacia 2CBS, has a broad substrate specificity. Substrates include 2-fluorobenzoate, 2-chlorobenzoate, 2-bromobenzoate, and 2-iodobenzoate, which are processed in this order of preference.