1.2.1.48: long-chain-aldehyde dehydrogenase

This is an abbreviated version!
For detailed information about long-chain-aldehyde dehydrogenase, go to the full flat file.

Word Map on EC 1.2.1.48

Reaction

a long-chain aldehyde
+
NAD+
+
H2O
=
a long-chain carboxylate
+
NADH
+ 2 H+

Synonyms

ALDH10, ALDH3A2, Aldh3b1, ALDH3B2, ALDH3B3, Bt-Aldh, dehydrogenase, long-chain aliphatic aldehyde, FALDH, fatty aldehyde dehydrogenase, fatty aldehyde:NAD+ oxidoreductase, long-chain aldehyde dehydrogenase, long-chain fatty aldehyde dehydrogenase, long-chain-aldehyde dehydrogenase, membrane-bound fatty aldehyde dehydrogenase

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.48 long-chain-aldehyde dehydrogenase

General Information

General Information on EC 1.2.1.48 - long-chain-aldehyde dehydrogenase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
malfunction
metabolism
-
the enzyme is not involved in the long-chain base metabolism
physiological function
additional information
the dimeric FALDH displays a an element in its C-terminal region, a gatekeeper helix, which extends over the adjacent subunit, controlling the access to the substrate cavity and helping orientate both substrate cavities towards the membrane surface for efficient substrate transit between membranes and catalytic site. The gatekeeper helix is important for directing the substrate specificity of FALDH towards long-chain fatty aldehydes. Cys241 is the catalytic cysteine in the human enzyme