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1.5.8.2: trimethylamine dehydrogenase

This is an abbreviated version!
For detailed information about trimethylamine dehydrogenase, go to the full flat file.

Word Map on EC 1.5.8.2

Reaction

trimethylamine
+
H2O
 +
electron-transfer flavoprotein
=
Dimethylamine
 +
formaldehyde
 +
reduced electron-transfer flavoprotein

Synonyms

EC 1.5.99.7, More, TMA dehydrogenase, TMADH, TMD, TMDH

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.8 With a flavin or flavoprotein as acceptor
                1.5.8.2 trimethylamine dehydrogenase

Engineering

Engineering on EC 1.5.8.2 - trimethylamine dehydrogenase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C-terminal truncations
-
C-terminal truncations of 5, 10 or 17 residues do not affect dimer stability, but compromise the ability of the enzyme to become covalently coupled with FMN in the active site
H172Q
-
no change of turnover, but 25fold increase of Km-value
V344I
-
increase of Km-value, decrease of turnover
Y442F
Y442G
Y442L
C-terminal truncations
-
C-terminal truncations of 5, 10 or 17 residues do not affect dimer stability, but compromise the ability of the enzyme to become covalently coupled with FMN in the active site
-
H172Q
-
no change of turnover, but 25fold increase of Km-value
-
V344I
-
increase of Km-value, decrease of turnover
-
Y442F
Y442G
Y442L